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Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source

(2014) ORGANIC & BIOMOLECULAR CHEMISTRY. 12(43). p.8683-8688
Author
Organization
Abstract
An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deuteration of the enantiopure (S)-Ketoprofen leads to the incorporation of three deuterium atoms with retention of molecular chirality.
Keywords
HYDROGEN ISOTOPE-EXCHANGE, H/D EXCHANGE, ORGANIC-COMPOUNDS, DEUTERATION, COMPLEXES, WATER, ACTIVATION, REACTIVITY, MECHANISM, PROTEINS

Citation

Please use this url to cite or link to this publication:

MLA
Piola, Lorenzo, et al. “Regioselective Ruthenium Catalysed H-D Exchange Using D2O as the Deuterium Source.” ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 43, 2014, pp. 8683–88.
APA
Piola, L., Fernandez-Salas, J. A., Manzini, S., & Nolan, S. (2014). Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source. ORGANIC & BIOMOLECULAR CHEMISTRY, 12(43), 8683–8688.
Chicago author-date
Piola, Lorenzo, Jose A Fernandez-Salas, Simone Manzini, and Steven Nolan. 2014. “Regioselective Ruthenium Catalysed H-D Exchange Using D2O as the Deuterium Source.” ORGANIC & BIOMOLECULAR CHEMISTRY 12 (43): 8683–88.
Chicago author-date (all authors)
Piola, Lorenzo, Jose A Fernandez-Salas, Simone Manzini, and Steven Nolan. 2014. “Regioselective Ruthenium Catalysed H-D Exchange Using D2O as the Deuterium Source.” ORGANIC & BIOMOLECULAR CHEMISTRY 12 (43): 8683–8688.
Vancouver
1.
Piola L, Fernandez-Salas JA, Manzini S, Nolan S. Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source. ORGANIC & BIOMOLECULAR CHEMISTRY. 2014;12(43):8683–8.
IEEE
[1]
L. Piola, J. A. Fernandez-Salas, S. Manzini, and S. Nolan, “Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source,” ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 43, pp. 8683–8688, 2014.
@article{8168538,
  abstract     = {An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deuteration of the enantiopure (S)-Ketoprofen leads to the incorporation of three deuterium atoms with retention of molecular chirality.},
  author       = {Piola, Lorenzo and Fernandez-Salas, Jose A and Manzini, Simone and Nolan, Steven},
  issn         = {1477-0520},
  journal      = {ORGANIC & BIOMOLECULAR CHEMISTRY},
  keywords     = {HYDROGEN ISOTOPE-EXCHANGE,H/D EXCHANGE,ORGANIC-COMPOUNDS,DEUTERATION,COMPLEXES,WATER,ACTIVATION,REACTIVITY,MECHANISM,PROTEINS},
  language     = {eng},
  number       = {43},
  pages        = {8683--8688},
  title        = {Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source},
  url          = {http://dx.doi.org/10.1039/c4ob01798f},
  volume       = {12},
  year         = {2014},
}

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