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A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols

(2014) CHEMISTRY-A EUROPEAN JOURNAL. 20(41). p.13132-13135
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Abstract
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantioenriched acetates in a one-pot reaction, probing the versatility of complex 2.
Keywords
dynamic kinetic resolution, enzyme catalysis, metal catalysis, racemization, ruthenium, CATALYTIC RACEMIZATION, ASYMMETRIC TRANSFORMATIONS, ENZYMATIC RESOLUTION, AMBIENT-TEMPERATURE, METAL CATALYSIS, CHIRAL ACETATES, ENOL ACETATES, LIPASE, KETONES, ENZYMES

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Chicago
Fernandez-Salas, Jose A, Simone Manzini, and Steven Nolan. 2014. “A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols.” Chemistry-a European Journal 20 (41): 13132–13135.
APA
Fernandez-Salas, J. A., Manzini, S., & Nolan, S. (2014). A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols. CHEMISTRY-A EUROPEAN JOURNAL, 20(41), 13132–13135.
Vancouver
1.
Fernandez-Salas JA, Manzini S, Nolan S. A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols. CHEMISTRY-A EUROPEAN JOURNAL. 2014;20(41):13132–5.
MLA
Fernandez-Salas, Jose A, Simone Manzini, and Steven Nolan. “A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols.” CHEMISTRY-A EUROPEAN JOURNAL 20.41 (2014): 13132–13135. Print.
@article{8168444,
  abstract     = {A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantioenriched acetates in a one-pot reaction, probing the versatility of complex 2.},
  author       = {Fernandez-Salas, Jose A and Manzini, Simone and Nolan, Steven},
  issn         = {0947-6539},
  journal      = {CHEMISTRY-A EUROPEAN JOURNAL},
  keyword      = {dynamic kinetic resolution,enzyme catalysis,metal catalysis,racemization,ruthenium,CATALYTIC RACEMIZATION,ASYMMETRIC TRANSFORMATIONS,ENZYMATIC RESOLUTION,AMBIENT-TEMPERATURE,METAL CATALYSIS,CHIRAL ACETATES,ENOL ACETATES,LIPASE,KETONES,ENZYMES},
  language     = {eng},
  number       = {41},
  pages        = {13132--13135},
  title        = {A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols},
  url          = {http://dx.doi.org/10.1002/chem.201404096},
  volume       = {20},
  year         = {2014},
}

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