Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds
- Author
- Jose A Fernandez-Salas, Enrico Marelli and Steven Nolan (UGent)
- Organization
- Abstract
- The first nickel catalyzed deprotonative cross coupling between C(sp(3))-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.
- Keywords
- CROSS-COUPLING REACTIONS, C-H FUNCTIONALIZATION, ALPHA-ARYLATION, ARYL CHLORIDES, BENZYLIC POSITION, ALKYL-HALIDES, NICKEL, PALLADIUM, ACTIVATION, BROMIDES
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8168380
- MLA
- Fernandez-Salas, Jose A., et al. “Synthesis of (Diarylmethyl)Amines Using Ni-Catalyzed Arylation of C(Sp(3))-H Bonds.” CHEMICAL SCIENCE, vol. 6, no. 8, 2015, pp. 4973–77.
- APA
- Fernandez-Salas, J. A., Marelli, E., & Nolan, S. (2015). Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds. CHEMICAL SCIENCE, 6(8), 4973–4977.
- Chicago author-date
- Fernandez-Salas, Jose A, Enrico Marelli, and Steven Nolan. 2015. “Synthesis of (Diarylmethyl)Amines Using Ni-Catalyzed Arylation of C(Sp(3))-H Bonds.” CHEMICAL SCIENCE 6 (8): 4973–77.
- Chicago author-date (all authors)
- Fernandez-Salas, Jose A, Enrico Marelli, and Steven Nolan. 2015. “Synthesis of (Diarylmethyl)Amines Using Ni-Catalyzed Arylation of C(Sp(3))-H Bonds.” CHEMICAL SCIENCE 6 (8): 4973–4977.
- Vancouver
- 1.Fernandez-Salas JA, Marelli E, Nolan S. Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds. CHEMICAL SCIENCE. 2015;6(8):4973–7.
- IEEE
- [1]J. A. Fernandez-Salas, E. Marelli, and S. Nolan, “Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds,” CHEMICAL SCIENCE, vol. 6, no. 8, pp. 4973–4977, 2015.
@article{8168380,
abstract = {The first nickel catalyzed deprotonative cross coupling between C(sp(3))-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.},
author = {Fernandez-Salas, Jose A and Marelli, Enrico and Nolan, Steven},
issn = {2041-6520},
journal = {CHEMICAL SCIENCE},
keywords = {CROSS-COUPLING REACTIONS,C-H FUNCTIONALIZATION,ALPHA-ARYLATION,ARYL CHLORIDES,BENZYLIC POSITION,ALKYL-HALIDES,NICKEL,PALLADIUM,ACTIVATION,BROMIDES},
language = {eng},
number = {8},
pages = {4973--4977},
title = {Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds},
url = {http://dx.doi.org/10.1039/c5sc01589h},
volume = {6},
year = {2015},
}
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