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Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds

(2015) CHEMICAL SCIENCE. 6(8). p.4973-4977
Author
Organization
Abstract
The first nickel catalyzed deprotonative cross coupling between C(sp(3))-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.
Keywords
CROSS-COUPLING REACTIONS, C-H FUNCTIONALIZATION, ALPHA-ARYLATION, ARYL CHLORIDES, BENZYLIC POSITION, ALKYL-HALIDES, NICKEL, PALLADIUM, ACTIVATION, BROMIDES

Citation

Please use this url to cite or link to this publication:

MLA
Fernandez-Salas, Jose A., et al. “Synthesis of (Diarylmethyl)Amines Using Ni-Catalyzed Arylation of C(Sp(3))-H Bonds.” CHEMICAL SCIENCE, vol. 6, no. 8, 2015, pp. 4973–77.
APA
Fernandez-Salas, J. A., Marelli, E., & Nolan, S. (2015). Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds. CHEMICAL SCIENCE, 6(8), 4973–4977.
Chicago author-date
Fernandez-Salas, Jose A, Enrico Marelli, and Steven Nolan. 2015. “Synthesis of (Diarylmethyl)Amines Using Ni-Catalyzed Arylation of C(Sp(3))-H Bonds.” CHEMICAL SCIENCE 6 (8): 4973–77.
Chicago author-date (all authors)
Fernandez-Salas, Jose A, Enrico Marelli, and Steven Nolan. 2015. “Synthesis of (Diarylmethyl)Amines Using Ni-Catalyzed Arylation of C(Sp(3))-H Bonds.” CHEMICAL SCIENCE 6 (8): 4973–4977.
Vancouver
1.
Fernandez-Salas JA, Marelli E, Nolan S. Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds. CHEMICAL SCIENCE. 2015;6(8):4973–7.
IEEE
[1]
J. A. Fernandez-Salas, E. Marelli, and S. Nolan, “Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds,” CHEMICAL SCIENCE, vol. 6, no. 8, pp. 4973–4977, 2015.
@article{8168380,
  abstract     = {The first nickel catalyzed deprotonative cross coupling between C(sp(3))-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.},
  author       = {Fernandez-Salas, Jose A and Marelli, Enrico and Nolan, Steven},
  issn         = {2041-6520},
  journal      = {CHEMICAL SCIENCE},
  keywords     = {CROSS-COUPLING REACTIONS,C-H FUNCTIONALIZATION,ALPHA-ARYLATION,ARYL CHLORIDES,BENZYLIC POSITION,ALKYL-HALIDES,NICKEL,PALLADIUM,ACTIVATION,BROMIDES},
  language     = {eng},
  number       = {8},
  pages        = {4973--4977},
  title        = {Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))-H bonds},
  url          = {http://dx.doi.org/10.1039/c5sc01589h},
  volume       = {6},
  year         = {2015},
}

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