Synthesis of an intermediate of nafoxidine via nickel-catalyzed ketone arylation
- Author
- Enrico Marelli, Jose A Fernandez Salas and Steven Nolan (UGent)
- Organization
- Abstract
- A nickel-catalyzed methodology for the -arylation of ketones has been applied to the synthesis of an industrially relevant intermediate. The optimization of the reaction shows the important influence of subtle changes in reaction conditions, and leads to an improved procedure employing only a small excess of the substrate and a relatively low catalyst loading.
- Keywords
- nickel, ketones, arylation, cross coupling, medicinal chemistry, CROSS-COUPLING REACTIONS, ORTHO-SUBSTITUTED BIARYLS, N-HETEROCYCLIC CARBENE, C BOND FORMATION, ALPHA-ARYLATION, ACYCLIC KETONES, ARYL CHLORIDES, PRE-CATALYST, PALLADIUM, COMPLEXES
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8168307
- MLA
- Marelli, Enrico, et al. “Synthesis of an Intermediate of Nafoxidine via Nickel-Catalyzed Ketone Arylation.” SYNTHESIS-STUTTGART, vol. 47, no. 14, 2015, pp. 2032–37.
- APA
- Marelli, E., Fernandez Salas, J. A., & Nolan, S. (2015). Synthesis of an intermediate of nafoxidine via nickel-catalyzed ketone arylation. SYNTHESIS-STUTTGART, 47(14), 2032–2037.
- Chicago author-date
- Marelli, Enrico, Jose A Fernandez Salas, and Steven Nolan. 2015. “Synthesis of an Intermediate of Nafoxidine via Nickel-Catalyzed Ketone Arylation.” SYNTHESIS-STUTTGART 47 (14): 2032–37.
- Chicago author-date (all authors)
- Marelli, Enrico, Jose A Fernandez Salas, and Steven Nolan. 2015. “Synthesis of an Intermediate of Nafoxidine via Nickel-Catalyzed Ketone Arylation.” SYNTHESIS-STUTTGART 47 (14): 2032–2037.
- Vancouver
- 1.Marelli E, Fernandez Salas JA, Nolan S. Synthesis of an intermediate of nafoxidine via nickel-catalyzed ketone arylation. SYNTHESIS-STUTTGART. 2015;47(14):2032–7.
- IEEE
- [1]E. Marelli, J. A. Fernandez Salas, and S. Nolan, “Synthesis of an intermediate of nafoxidine via nickel-catalyzed ketone arylation,” SYNTHESIS-STUTTGART, vol. 47, no. 14, pp. 2032–2037, 2015.
@article{8168307,
abstract = {A nickel-catalyzed methodology for the -arylation of ketones has been applied to the synthesis of an industrially relevant intermediate. The optimization of the reaction shows the important influence of subtle changes in reaction conditions, and leads to an improved procedure employing only a small excess of the substrate and a relatively low catalyst loading.},
author = {Marelli, Enrico and Fernandez Salas, Jose A and Nolan, Steven},
issn = {0039-7881},
journal = {SYNTHESIS-STUTTGART},
keywords = {nickel,ketones,arylation,cross coupling,medicinal chemistry,CROSS-COUPLING REACTIONS,ORTHO-SUBSTITUTED BIARYLS,N-HETEROCYCLIC CARBENE,C BOND FORMATION,ALPHA-ARYLATION,ACYCLIC KETONES,ARYL CHLORIDES,PRE-CATALYST,PALLADIUM,COMPLEXES},
language = {eng},
number = {14},
pages = {2032--2037},
title = {Synthesis of an intermediate of nafoxidine via nickel-catalyzed ketone arylation},
url = {http://dx.doi.org/10.1055/s-0034-1380813},
volume = {47},
year = {2015},
}
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