@article{8167713,
  abstract     = {Objective: To compare the performance of PI-RADSv2 with PI-RADSv1 in patients with elevated PSA before biopsy. 
Methods: 245 patients with elevated PSA underwent mpMRI before biopsy between May 2011 and December 2014 at 3.0 Tesla without endorectal coil. Patients underwent transrectal ultrasound-guided systematic 12-core biopsy followed by radical prostatectomy (N = 68), radiation therapy (N = 91) or clinical follow-up for at least two years (N = 86). All exams were scored on a per-patient basis according to PI-RADSv1 and PI-RADSv2. ClinsigPC was defined as Gleason score >= 7 (including 3+4 with prominent but not predominant Gleason 4 component), and/or tumour volume of >= 0.5cc, and/or tumour stage >= T3a. 
Results: In 144 patients (58.8%) a ClinsigPC was found within two years after mpMRI. The PI-RADSv1 and PI-RADSv2 overall assessment scores were significantly higher (P < 0.001) in patients with ClinsigPC as compared to patients without ClinsigPC. ROC analysis showed an area under the curve of 0.82 (CI 0.76-0.87) for PI-RADSv1 and 0.79 (CI 0.73-0.85) for PI-RADSv2 (P: NS). A threshold score of 3 exhibited sensitivities of 88.2% and 79.2% (P = 0.001) and specificities of 64.4% and 67.3% (P: NS) with PI-RADSv1 and PI-RADSv2, respectively. 
Conclusions: The mpMRI scoring systems PI-RADSv1 and PI-RADSv2 yield similar accuracy to detect ClinsigPC in patients with elevated PSA, although clinicians should be aware that when an overall assessment score of 3 is used as a threshold for a positive mpMRI, PI-RADSv2 has lower sensitivity than PI-RADSv1. Nevertheless, PI-RADSv2 is preferable over PI-RADSv1 because it has the advantage of providing well-defined instructions on how to determine the overall assessment category.},
  articleno    = {108},
  author       = {De Visschere, Pieter and Pattyn, Eva and Ost, Piet and Claeys, Tom and Lumen, Nicolaas and Villeirs, Geert},
  issn         = {1780-2393},
  journal      = {JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY},
  keywords     = {Prostate neoplasms,Magnetic Resonance Imaging,Diffusion Weighted Imaging,MR spectroscopic imaging,Prostate cancer,SCORING SYSTEM,MULTIPARAMETRIC MRI,REFERENCE-STANDARD,CANCER,VALIDATION,BIOPSY,AGREEMENT,DIAGNOSIS,ACCURACY},
  language     = {eng},
  number       = {1},
  pages        = {10},
  title        = {Comparison of the Prostate Imaging Reporting and Data System (PI-RADS) version 1 and 2 in a cohort of 245 patients with histopathological reference and long-term follow-up},
  url          = {http://dx.doi.org/10.5334/jbr-btr.1147},
  volume       = {100},
  year         = {2016},
}

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