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Mouse models of ageing and their relevance to disease

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Abstract
Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.
Keywords
Ageing, Mouse models, Delayed ageing, Accelerated ageing, Caloric restriction, HUTCHINSON-GILFORD PROGERIA, MITOCHONDRIAL-DNA MUTATIONS, DETERMINING ATHEROSCLEROSIS SUSCEPTIBILITY, GENETICALLY HETEROGENEOUS MICE, INTERVENTIONS TESTING PROGRAM, LIFELONG CALORIC RESTRICTION, WOLFRAMIN WFS1 GENE, MTDNA MUTATOR MICE, AMES DWARF MICE, DIETARY RESTRICTION

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Chicago
Kõks, Sulev, Soner Dogan, Bilge Guvenc Tuna, Herminia González-Navarro, Paul Potter, and Roosmarijn Vandenbroucke. 2016. “Mouse Models of Ageing and Their Relevance to Disease.” Mechanisms of Ageing and Development 160: 41–53.
APA
Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. (2016). Mouse models of ageing and their relevance to disease. MECHANISMS OF AGEING AND DEVELOPMENT, 160, 41–53.
Vancouver
1.
Kõks S, Dogan S, Tuna BG, González-Navarro H, Potter P, Vandenbroucke R. Mouse models of ageing and their relevance to disease. MECHANISMS OF AGEING AND DEVELOPMENT. 2016;160:41–53.
MLA
Kõks, Sulev, Soner Dogan, Bilge Guvenc Tuna, et al. “Mouse Models of Ageing and Their Relevance to Disease.” MECHANISMS OF AGEING AND DEVELOPMENT 160 (2016): 41–53. Print.
@article{8167409,
  abstract     = {Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.},
  author       = {K{\~o}ks, Sulev and Dogan, Soner and Tuna, Bilge Guvenc and Gonz{\'a}lez-Navarro, Herminia and Potter, Paul and Vandenbroucke, Roosmarijn},
  issn         = {0047-6374},
  journal      = {MECHANISMS OF AGEING AND DEVELOPMENT},
  language     = {eng},
  pages        = {41--53},
  title        = {Mouse models of ageing and their relevance to disease},
  url          = {http://dx.doi.org/10.1016/j.mad.2016.10.001},
  volume       = {160},
  year         = {2016},
}

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