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With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions

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Abstract
Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments can come from a better understanding of the pathogenic pathways which, in turn, can be derived from models of disease. Therefore the more closely the model resembles the disease situation the more likely relevant the data will be that is generated from them. Here we review the state of knowledge of mouse models of a range of diseases and aspects of an ageing physiology that are all germane to ageing. We also give recommendations on the most common mouse models on their relevance to the clinical situations occurring in aged patients and look forward as to how research in ageing models can be carried out. As we continue to elucidate the pathophysiology of disease, often through mouse models, we also learn what is needed to refine these models. Such factors can include better models, reflecting the ageing patient population, or a better phenotypic understanding of existing models.
Keywords
Mouse models, Ageing, Phenotyping, SENESCENCE-ACCELERATED MOUSE, TRAUMATIC BRAIN-INJURY, LONG-TERM POTENTIATION, TRIPLE-TRANSGENIC MODEL, CELL-MEDIATED-IMMUNITY, NECROSIS-FACTOR-ALPHA, CLOSED-BONE-FRACTURE, C-REACTIVE PROTEIN, ACTIVATION IN-VIVO, E-DEFICIENT MICE

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Citation

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MLA
Drechsler, Susanne et al. “With Mouse Age Comes Wisdom : a Review and Suggestions of Relevant Mouse Models for Age-related Conditions.” MECHANISMS OF AGEING AND DEVELOPMENT 160 (2016): 54–68. Print.
APA
Drechsler, S., Lynch, M. A., Novella, S., González-Navarro, H., Hecimovic, S., Barini, E., Tucci, V., et al. (2016). With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions. MECHANISMS OF AGEING AND DEVELOPMENT, 160, 54–68.
Chicago author-date
Drechsler, Susanne, Marina A Lynch, Susana Novella, Herminia González-Navarro, Silva Hecimovic, Erica Barini, Valter Tucci, et al. 2016. “With Mouse Age Comes Wisdom : a Review and Suggestions of Relevant Mouse Models for Age-related Conditions.” Mechanisms of Ageing and Development 160: 54–68.
Chicago author-date (all authors)
Drechsler, Susanne, Marina A Lynch, Susana Novella, Herminia González-Navarro, Silva Hecimovic, Erica Barini, Valter Tucci, Rui E Castro, Roosmarijn Vandenbroucke, Marcin Osuchowski, and Paul K Potter. 2016. “With Mouse Age Comes Wisdom : a Review and Suggestions of Relevant Mouse Models for Age-related Conditions.” Mechanisms of Ageing and Development 160: 54–68.
Vancouver
1.
Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, et al. With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions. MECHANISMS OF AGEING AND DEVELOPMENT. 2016;160:54–68.
IEEE
[1]
S. Drechsler et al., “With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions,” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 160, pp. 54–68, 2016.
@article{8167026,
  abstract     = {Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments can come from a better understanding of the pathogenic pathways which, in turn, can be derived from models of disease. Therefore the more closely the model resembles the disease situation the more likely relevant the data will be that is generated from them. Here we review the state of knowledge of mouse models of a range of diseases and aspects of an ageing physiology that are all germane to ageing. We also give recommendations on the most common mouse models on their relevance to the clinical situations occurring in aged patients and look forward as to how research in ageing models can be carried out. As we continue to elucidate the pathophysiology of disease, often through mouse models, we also learn what is needed to refine these models. Such factors can include better models, reflecting the ageing patient population, or a better phenotypic understanding of existing models.},
  author       = {Drechsler, Susanne and Lynch, Marina A and Novella, Susana and González-Navarro, Herminia and Hecimovic, Silva and Barini, Erica and Tucci, Valter and Castro, Rui E and Vandenbroucke, Roosmarijn and Osuchowski, Marcin and Potter, Paul K},
  issn         = {0047-6374},
  journal      = {MECHANISMS OF AGEING AND DEVELOPMENT},
  keywords     = {Mouse models,Ageing,Phenotyping,SENESCENCE-ACCELERATED MOUSE,TRAUMATIC BRAIN-INJURY,LONG-TERM POTENTIATION,TRIPLE-TRANSGENIC MODEL,CELL-MEDIATED-IMMUNITY,NECROSIS-FACTOR-ALPHA,CLOSED-BONE-FRACTURE,C-REACTIVE PROTEIN,ACTIVATION IN-VIVO,E-DEFICIENT MICE},
  language     = {eng},
  pages        = {54--68},
  title        = {With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions},
  url          = {http://dx.doi.org/10.1016/j.mad.2016.07.005},
  volume       = {160},
  year         = {2016},
}

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