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IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Dorine Sichien (UGent) , Charlotte Scott (UGent) , Liesbet Martens (UGent) , Matthias Vanderkerken, Sofie Van Gassen (UGent) , Maud Plantinga (UGent) , Thorsten Joeris, Sofie De Prijck (UGent) , Leen Vanhoutte (UGent) , Manon Vanheerswynghels (UGent) , et al.
(2016) IMMUNITY. 45(3). p.626-640
Author
Organization
Abstract
Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains highly expressed in differentiated DCs. Transcription factors that are required to maintain the identity of terminally differentiated cells are designated '' terminal selectors.'' Using BM chimeras, conditional Irf8(fl/fl) mice and various promotors to target Cre recombinase to different stages of monocyte and DC development, we have identified IRF8 as a terminal selector of the cDC1 lineage controlling survival. In monocytes, IRF8 was necessary during early but not late development. Complete or late deletion of IRF8 had no effect on pDC development or survival but altered their phenotype and gene-expression profile leading to increased T cell stimulatory function but decreased type 1 interferon production. Thus, IRF8 differentially controls the survival and function of terminally differentiated monocytes, cDC1s, and pDCs.
Keywords
LEUKEMIA-LIKE SYNDROME, CLONOGENIC PROGENITOR, STEADY-STATE, BONE-MARROW, FACTOR E2-2, IN-VIVO, MOUSE, LINEAGE, MACROPHAGES, HOMEOSTASIS

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MLA
Sichien, Dorine, et al. “IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.” IMMUNITY, vol. 45, no. 3, 2016, pp. 626–40, doi:10.1016/j.immuni.2016.08.013.
APA
Sichien, D., Scott, C., Martens, L., Vanderkerken, M., Van Gassen, S., Plantinga, M., … Guilliams, M. (2016). IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively. IMMUNITY, 45(3), 626–640. https://doi.org/10.1016/j.immuni.2016.08.013
Chicago author-date
Sichien, Dorine, Charlotte Scott, Liesbet Martens, Matthias Vanderkerken, Sofie Van Gassen, Maud Plantinga, Thorsten Joeris, et al. 2016. “IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.” IMMUNITY 45 (3): 626–40. https://doi.org/10.1016/j.immuni.2016.08.013.
Chicago author-date (all authors)
Sichien, Dorine, Charlotte Scott, Liesbet Martens, Matthias Vanderkerken, Sofie Van Gassen, Maud Plantinga, Thorsten Joeris, Sofie De Prijck, Leen Vanhoutte, Manon Vanheerswynghels, Gert Van Isterdael, Wendy Toussaint, Filipe Branco Madeira, Karl Vergote, William W Agace, Björn E Clausen, Hamida Hammad, Marc Dalod, Yvan Saeys, Bart Lambrecht, and Martin Guilliams. 2016. “IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.” IMMUNITY 45 (3): 626–640. doi:10.1016/j.immuni.2016.08.013.
Vancouver
1.
Sichien D, Scott C, Martens L, Vanderkerken M, Van Gassen S, Plantinga M, et al. IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively. IMMUNITY. 2016;45(3):626–40.
IEEE
[1]
D. Sichien et al., “IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively,” IMMUNITY, vol. 45, no. 3, pp. 626–640, 2016.
@article{8163962,
  abstract     = {{Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains highly expressed in differentiated DCs. Transcription factors that are required to maintain the identity of terminally differentiated cells are designated '' terminal selectors.'' Using BM chimeras, conditional Irf8(fl/fl) mice and various promotors to target Cre recombinase to different stages of monocyte and DC development, we have identified IRF8 as a terminal selector of the cDC1 lineage controlling survival. In monocytes, IRF8 was necessary during early but not late development. Complete or late deletion of IRF8 had no effect on pDC development or survival but altered their phenotype and gene-expression profile leading to increased T cell stimulatory function but decreased type 1 interferon production. Thus, IRF8 differentially controls the survival and function of terminally differentiated monocytes, cDC1s, and pDCs.}},
  author       = {{Sichien, Dorine and Scott, Charlotte and Martens, Liesbet and Vanderkerken, Matthias and Van Gassen, Sofie and Plantinga, Maud and Joeris, Thorsten and De Prijck, Sofie and Vanhoutte, Leen and Vanheerswynghels, Manon and Van Isterdael, Gert and Toussaint, Wendy and Branco Madeira, Filipe and Vergote, Karl and Agace, William W and Clausen, Björn E and Hammad, Hamida and Dalod, Marc and Saeys, Yvan and Lambrecht, Bart and Guilliams, Martin}},
  issn         = {{1074-7613}},
  journal      = {{IMMUNITY}},
  keywords     = {{LEUKEMIA-LIKE SYNDROME,CLONOGENIC PROGENITOR,STEADY-STATE,BONE-MARROW,FACTOR E2-2,IN-VIVO,MOUSE,LINEAGE,MACROPHAGES,HOMEOSTASIS}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{626--640}},
  title        = {{IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively}},
  url          = {{http://doi.org/10.1016/j.immuni.2016.08.013}},
  volume       = {{45}},
  year         = {{2016}},
}
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