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Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps

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Abstract
BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks has not been fully investigated yet. OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness. METHODS: We evaluated the prevalence and characteristics of alcohol-induced respiratory complaints in 1281 subjects. Nasal polyp (CRSwNP) patients with and without NSAID exacerbated respiratory disease (NERD), chronic rhinosinusitis patients without nasal polyps (CRSsNP), allergic rhinitis (AR) patients and healthy controls were approached by means of a questionnaire. Inflammatory markers (ECP, IL-5, IgE, SAE specific IgE, IL-17, TNFα and IFNγ) in tissue were then compared between alcohol hyper-responsive and non-hyper-responsive CRSwNP patients. RESULTS: The highest prevalence of nasal and bronchial alcohol hyper-responsiveness was observed in patients with NERD, followed by CRSwNP, and less frequent in CRSsNP, AR and healthy controls. Alcohol hyper-responsiveness is significantly more prevalent in CRSwNP patients suffering from recurrent disease and in patients with severe symptomatology. In nasal tissue of the hyper-responsive CRSwNP group we observed significantly higher nasal levels of the eosinophilic biomarker ECP. CONCLUSION & CLINICAL RELEVANCE: Nasal hyper-responsiveness to alcohol is significantly more prevalent in severe eosinophilic upper airway disease.
Keywords
airway hyper-responsiveness, alcohol, allergic rhinitis, chronic rhinosinusitis patients without nasal polyps, chronic rhinosinusitis with nasal polyps, NSAID exacerbated respiratory disease, EXACERBATED RESPIRATORY-DISEASE, WINE PROVOCATION TEST, NATURAL-HISTORY, INDUCED ASTHMA, PREVALENCE, SYMPTOMS, HISTAMINE, HEALTH, CONSUMPTION, EXPOSURE

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Citation

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Chicago
De Schryver, Els, Lara Derycke, Paloma Campo, Eline Gabriels, Guy Joos, Thibaut Van Zele, Claus Bachert, Peter W Hellings, and Philippe Gevaert. 2017. “Alcohol Hyper-responsiveness in Chronic Rhinosinusitis with Nasal Polyps.” Clinical and Experimental Allergy 47 (2): 245–253.
APA
De Schryver, Els, Derycke, L., Campo, P., Gabriels, E., Joos, G., Van Zele, T., Bachert, C., et al. (2017). Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps. CLINICAL AND EXPERIMENTAL ALLERGY, 47(2), 245–253.
Vancouver
1.
De Schryver E, Derycke L, Campo P, Gabriels E, Joos G, Van Zele T, et al. Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps. CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(2):245–53.
MLA
De Schryver, Els, Lara Derycke, Paloma Campo, et al. “Alcohol Hyper-responsiveness in Chronic Rhinosinusitis with Nasal Polyps.” CLINICAL AND EXPERIMENTAL ALLERGY 47.2 (2017): 245–253. Print.
@article{8138099,
  abstract     = {BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks has not been fully investigated yet.
OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness.
METHODS: We evaluated the prevalence and characteristics of alcohol-induced respiratory complaints in 1281 subjects. Nasal polyp (CRSwNP) patients with and without NSAID exacerbated respiratory disease (NERD), chronic rhinosinusitis patients without nasal polyps (CRSsNP), allergic rhinitis (AR) patients and healthy controls were approached by means of a questionnaire. Inflammatory markers (ECP, IL-5, IgE, SAE specific IgE, IL-17, TNF\ensuremath{\alpha} and IFN\ensuremath{\gamma}) in tissue were then compared between alcohol hyper-responsive and non-hyper-responsive CRSwNP patients.
RESULTS: The highest prevalence of nasal and bronchial alcohol hyper-responsiveness was observed in patients with NERD, followed by CRSwNP, and less frequent in CRSsNP, AR and healthy controls. Alcohol hyper-responsiveness is significantly more prevalent in CRSwNP patients suffering from recurrent disease and in patients with severe symptomatology. In nasal tissue of the hyper-responsive CRSwNP group we observed significantly higher nasal levels of the eosinophilic biomarker ECP.
CONCLUSION \& CLINICAL RELEVANCE: Nasal hyper-responsiveness to alcohol is significantly more prevalent in severe eosinophilic upper airway disease.},
  author       = {De Schryver, Els and Derycke, Lara and Campo, Paloma and Gabriels, Eline and Joos, Guy and Van Zele, Thibaut and Bachert, Claus and Hellings, Peter W and Gevaert, Philippe},
  issn         = {0954-7894},
  journal      = {CLINICAL AND EXPERIMENTAL ALLERGY},
  keyword      = {airway hyper-responsiveness,alcohol,allergic rhinitis,chronic rhinosinusitis patients without nasal polyps,chronic rhinosinusitis with nasal polyps,NSAID exacerbated respiratory disease,EXACERBATED RESPIRATORY-DISEASE,WINE PROVOCATION TEST,NATURAL-HISTORY,INDUCED ASTHMA,PREVALENCE,SYMPTOMS,HISTAMINE,HEALTH,CONSUMPTION,EXPOSURE},
  language     = {eng},
  number       = {2},
  pages        = {245--253},
  title        = {Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps},
  url          = {http://dx.doi.org/10.1111/cea.12836},
  volume       = {47},
  year         = {2017},
}

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