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Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps

Els De Schryver UGent, Lara Derycke UGent, Paloma Campo, Eline Gabriels, Guy Joos UGent, Thibaut Van Zele UGent, Claus Bachert UGent, Peter W Hellings and Philippe Gevaert UGent (2017) CLINICAL AND EXPERIMENTAL ALLERGY. 47(2). p.245-253
abstract
BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks has not been fully investigated yet. OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness. METHODS: We evaluated the prevalence and characteristics of alcohol-induced respiratory complaints in 1281 subjects. Nasal polyp (CRSwNP) patients with and without NSAID exacerbated respiratory disease (NERD), chronic rhinosinusitis patients without nasal polyps (CRSsNP), allergic rhinitis (AR) patients and healthy controls were approached by means of a questionnaire. Inflammatory markers (ECP, IL-5, IgE, SAE specific IgE, IL-17, TNFα and IFNγ) in tissue were then compared between alcohol hyper-responsive and non-hyper-responsive CRSwNP patients. RESULTS: The highest prevalence of nasal and bronchial alcohol hyper-responsiveness was observed in patients with NERD, followed by CRSwNP, and less frequent in CRSsNP, AR and healthy controls. Alcohol hyper-responsiveness is significantly more prevalent in CRSwNP patients suffering from recurrent disease and in patients with severe symptomatology. In nasal tissue of the hyper-responsive CRSwNP group we observed significantly higher nasal levels of the eosinophilic biomarker ECP. CONCLUSION & CLINICAL RELEVANCE: Nasal hyper-responsiveness to alcohol is significantly more prevalent in severe eosinophilic upper airway disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
airway hyper-responsiveness, alcohol, allergic rhinitis, chronic rhinosinusitis patients without nasal polyps, chronic rhinosinusitis with nasal polyps, NSAID exacerbated respiratory disease, EXACERBATED RESPIRATORY-DISEASE, WINE PROVOCATION TEST, NATURAL-HISTORY, INDUCED ASTHMA, PREVALENCE, SYMPTOMS, HISTAMINE, HEALTH, CONSUMPTION, EXPOSURE
journal title
CLINICAL AND EXPERIMENTAL ALLERGY
Clin. Exp. Allergy
volume
47
issue
2
pages
245 - 253
Web of Science type
Article
Web of Science id
000396912300011
ISSN
0954-7894
DOI
10.1111/cea.12836
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8138099
handle
http://hdl.handle.net/1854/LU-8138099
date created
2016-11-10 10:05:25
date last changed
2017-10-11 11:24:01
@article{8138099,
  abstract     = {BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks has not been fully investigated yet.
OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness.
METHODS: We evaluated the prevalence and characteristics of alcohol-induced respiratory complaints in 1281 subjects. Nasal polyp (CRSwNP) patients with and without NSAID exacerbated respiratory disease (NERD), chronic rhinosinusitis patients without nasal polyps (CRSsNP), allergic rhinitis (AR) patients and healthy controls were approached by means of a questionnaire. Inflammatory markers (ECP, IL-5, IgE, SAE specific IgE, IL-17, TNF\ensuremath{\alpha} and IFN\ensuremath{\gamma}) in tissue were then compared between alcohol hyper-responsive and non-hyper-responsive CRSwNP patients.
RESULTS: The highest prevalence of nasal and bronchial alcohol hyper-responsiveness was observed in patients with NERD, followed by CRSwNP, and less frequent in CRSsNP, AR and healthy controls. Alcohol hyper-responsiveness is significantly more prevalent in CRSwNP patients suffering from recurrent disease and in patients with severe symptomatology. In nasal tissue of the hyper-responsive CRSwNP group we observed significantly higher nasal levels of the eosinophilic biomarker ECP.
CONCLUSION \& CLINICAL RELEVANCE: Nasal hyper-responsiveness to alcohol is significantly more prevalent in severe eosinophilic upper airway disease.},
  author       = {De Schryver, Els and Derycke, Lara and Campo, Paloma and Gabriels, Eline and Joos, Guy and Van Zele, Thibaut and Bachert, Claus and Hellings, Peter W and Gevaert, Philippe},
  issn         = {0954-7894},
  journal      = {CLINICAL AND EXPERIMENTAL ALLERGY},
  keyword      = {airway hyper-responsiveness,alcohol,allergic rhinitis,chronic rhinosinusitis patients without nasal polyps,chronic rhinosinusitis with nasal polyps,NSAID exacerbated respiratory disease,EXACERBATED RESPIRATORY-DISEASE,WINE PROVOCATION TEST,NATURAL-HISTORY,INDUCED ASTHMA,PREVALENCE,SYMPTOMS,HISTAMINE,HEALTH,CONSUMPTION,EXPOSURE},
  language     = {eng},
  number       = {2},
  pages        = {245--253},
  title        = {Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps},
  url          = {http://dx.doi.org/10.1111/cea.12836},
  volume       = {47},
  year         = {2017},
}

Chicago
De Schryver, Els, Lara Derycke, Paloma Campo, Eline Gabriels, Guy Joos, Thibaut Van Zele, Claus Bachert, Peter W Hellings, and Philippe Gevaert. 2017. “Alcohol Hyper-responsiveness in Chronic Rhinosinusitis with Nasal Polyps.” Clinical and Experimental Allergy 47 (2): 245–253.
APA
De Schryver, E., Derycke, L., Campo, P., Gabriels, E., Joos, G., Van Zele, T., Bachert, C., et al. (2017). Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps. CLINICAL AND EXPERIMENTAL ALLERGY, 47(2), 245–253.
Vancouver
1.
De Schryver E, Derycke L, Campo P, Gabriels E, Joos G, Van Zele T, et al. Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps. CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(2):245–53.
MLA
De Schryver, Els, Lara Derycke, Paloma Campo, et al. “Alcohol Hyper-responsiveness in Chronic Rhinosinusitis with Nasal Polyps.” CLINICAL AND EXPERIMENTAL ALLERGY 47.2 (2017): 245–253. Print.