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Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate

Pieter De Visschere (UGent) , Anne Vral (UGent) , Gianpaolo Perletti (UGent) , EVA PATTYN (UGent) , Marleen Praet (UGent) , Vittorio Magri and Geert Villeirs (UGent)
(2017) EUROPEAN RADIOLOGY. 27(5). p.2095-2109
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Abstract
Objectives: To identify the multiparametric magnetic resonance imaging (mpMRI) characteristics of normal, benign and malignant conditions in the prostate. Methods: Fifty-six histopathological whole-mount radical prostatectomy specimens from ten randomly selected patients with prostate cancer (PC) were matched with corresponding transverse mpMRI slices. The mpMRI was performed prior to biopsy and consisted of T2-weighted imaging (T2-WI), diffusion-weighted imaging (DWI), dynamic contrastenhanced imaging (DCE) and magnetic resonance spectroscopic imaging (MRSI). Results: In each prostate specimen, a wide range of histopathological conditions were observed. They showed consistent but overlapping characteristics on mpMRI. Normal glands in the transition zone showed lower signal intensity (SI) on T2-WI, lower ADC values and lower citrate peaks on MRSI as compared to the peripheral zone (PZ) due to sparser glandular elements and more prominent collagenous fibres. In the PZ, normal glands were iso-intense on T2-WI, while high SI areas represented cystic atrophy. Mimickers of well-differentiated PC on mpMRI were inflammation, adenosis, HG-PIN and post-atrophic hyperplasia. Conclusion: Each prostate is a unique mix of normal, benign and/or malignant areas that vary in extent and distribution resulting in very heterogeneous characteristics on mpMRI. Understanding the main concepts of this mpMRIhistopathological correlation may increase the diagnostic confidence in reporting mpMRI.
Keywords
Prostatic atrophy, Prostatic hyperplasia, Inflammation, Prostate cancer, Magnetic resonance imaging, APPARENT DIFFUSION-COEFFICIENT, INTRAEPITHELIAL NEOPLASIA, MR SPECTROSCOPY, CANCER, ANATOMY, LESIONS, DIFFERENTIATION, ADENOCARCINOMA, CLASSIFICATION, INFLAMMATION

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Chicago
De Visschere, Pieter, Anne Vral, Gianpaolo Perletti, EVA PATTYN, Marleen Praet, Vittorio Magri, and Geert Villeirs. 2017. “Multiparametric Magnetic Resonance Imaging Characteristics of Normal, Benign and Malignant Conditions in the Prostate.” European Radiology 27 (5): 2095–2109.
APA
De Visschere, Pieter, Vral, A., Perletti, G., PATTYN, E., Praet, M., Magri, V., & Villeirs, G. (2017). Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate. EUROPEAN RADIOLOGY, 27(5), 2095–2109.
Vancouver
1.
De Visschere P, Vral A, Perletti G, PATTYN E, Praet M, Magri V, et al. Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate. EUROPEAN RADIOLOGY. 2017;27(5):2095–109.
MLA
De Visschere, Pieter, Anne Vral, Gianpaolo Perletti, et al. “Multiparametric Magnetic Resonance Imaging Characteristics of Normal, Benign and Malignant Conditions in the Prostate.” EUROPEAN RADIOLOGY 27.5 (2017): 2095–2109. Print.
@article{8135292,
  abstract     = {Objectives: To identify the multiparametric magnetic resonance imaging (mpMRI) characteristics of normal, benign and malignant conditions in the prostate.
Methods: Fifty-six histopathological whole-mount radical prostatectomy specimens from ten randomly selected patients with prostate cancer (PC) were matched with corresponding transverse mpMRI slices. The mpMRI was performed prior to biopsy and consisted of T2-weighted imaging (T2-WI), diffusion-weighted imaging (DWI), dynamic contrastenhanced imaging (DCE) and magnetic resonance spectroscopic imaging (MRSI).
Results: In each prostate specimen, a wide range of histopathological conditions were observed. They showed consistent but overlapping characteristics on mpMRI. Normal glands in the transition zone showed lower signal intensity (SI) on T2-WI, lower ADC values and lower citrate peaks on MRSI as compared to the peripheral zone (PZ) due to sparser glandular elements and more prominent collagenous fibres. In the PZ, normal glands were iso-intense on T2-WI, while high SI areas represented cystic atrophy. Mimickers of well-differentiated PC on mpMRI were inflammation, adenosis, HG-PIN and post-atrophic hyperplasia.
Conclusion: Each prostate is a unique mix of normal, benign and/or malignant areas that vary in extent and distribution resulting in very heterogeneous characteristics on mpMRI. Understanding the main concepts of this mpMRIhistopathological correlation may increase the diagnostic confidence in reporting mpMRI.},
  author       = {De Visschere, Pieter and Vral, Anne and Perletti, Gianpaolo and PATTYN, EVA and Praet, Marleen and Magri, Vittorio and Villeirs, Geert},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  language     = {eng},
  number       = {5},
  pages        = {2095--2109},
  title        = {Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate},
  url          = {http://dx.doi.org/10.1007/s00330-016-4479-z},
  volume       = {27},
  year         = {2017},
}

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