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Modeling the drug transport during intraperitoneal chemotherapy

(2016)
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Abstract
ABSTRACT: Patients with peritoneal carcinomatosis suffer from a widespread metastatic growth of tumor nodules in the peritoneal cavity. Intraperitoneal (IP) chemotherapy is a potential alternative treatment, that may allow for higher intratumor concentrations of the cytotoxic agent and less side effects compared to conventional intravenous administration. Although IP chemotherapy is a promising technique, its clinical application is still limited due to the poor drug penetration (typically a few millimeters) in the tumor tissue. It is thus essential to better understand the drug transport during IP chemotherapy. To this end, we developed a computational fluid dynamics (CFD) model of a 3D tumor nodule that allows for testing the influence of therapy-related parameters on drug penetration. The model includes the convective, diffusive and reactive drug transport in different tumor geometries with a necrotic core (e.g. a spherical baseline model with radius r = 1 cm and rnecrotic = 5 mm). The baseline model was adapted to perform a parameter study of therapy-related parameters (i.e. different tumor geometries, types of drugs, tissue permeability, presence of necrotic core, vascular properties etc.). This modelling approach enables simulating the drug penetration depth and local drug concentrations for different sets of parameters, which may eventually lead to the optimization of drug transport during IP chemotherapy.

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MLA
Steuperaert, Margo, Giuseppe Falve D’Urso Labate, Charlotte Debbaut, et al. “Modeling the Drug Transport During Intraperitoneal Chemotherapy.” 2016. Print.
APA
Steuperaert, M., Falve D’Urso Labate, G., Debbaut, C., Ceelen, W., & Segers, P. (2016). Modeling the drug transport during intraperitoneal chemotherapy. Presented at the Oncopoint.
Chicago author-date
Steuperaert, Margo, Giuseppe Falve D’Urso Labate, Charlotte Debbaut, Wim Ceelen, and Patrick Segers. 2016. “Modeling the Drug Transport During Intraperitoneal Chemotherapy.” In .
Chicago author-date (all authors)
Steuperaert, Margo, Giuseppe Falve D’Urso Labate, Charlotte Debbaut, Wim Ceelen, and Patrick Segers. 2016. “Modeling the Drug Transport During Intraperitoneal Chemotherapy.” In .
Vancouver
1.
Steuperaert M, Falve D’Urso Labate G, Debbaut C, Ceelen W, Segers P. Modeling the drug transport during intraperitoneal chemotherapy. 2016.
IEEE
[1]
M. Steuperaert, G. Falve D’Urso Labate, C. Debbaut, W. Ceelen, and P. Segers, “Modeling the drug transport during intraperitoneal chemotherapy,” presented at the Oncopoint, Ghent, Belgium, 2016.
@inproceedings{8134619,
  abstract     = {ABSTRACT: Patients with peritoneal carcinomatosis suffer from a widespread metastatic growth of tumor nodules in the peritoneal cavity. Intraperitoneal (IP) chemotherapy is a potential alternative treatment, that may allow for higher intratumor concentrations of the cytotoxic agent and less side effects compared to conventional intravenous administration. Although IP chemotherapy is a promising technique, its clinical application is still limited due to the poor drug penetration (typically a few millimeters) in the tumor tissue. It is thus essential to better understand the drug transport during IP chemotherapy. To this end, we developed a computational fluid dynamics (CFD) model of a 3D tumor nodule that allows for testing the influence of therapy-related parameters on drug penetration. The model includes the convective, diffusive and reactive drug transport in different tumor geometries with a necrotic core (e.g. a spherical baseline model with radius r = 1 cm and rnecrotic = 5 mm). The baseline model was adapted to perform a parameter study of therapy-related parameters (i.e. different tumor geometries, types of drugs, tissue permeability, presence of necrotic core, vascular properties etc.). This modelling approach enables simulating the drug penetration depth and local drug concentrations for different sets of parameters, which may eventually lead to the optimization of drug transport during IP chemotherapy.},
  author       = {Steuperaert, Margo and Falve D'Urso Labate, Giuseppe and Debbaut, Charlotte and Ceelen, Wim and Segers, Patrick},
  language     = {eng},
  location     = {Ghent, Belgium},
  title        = {Modeling the drug transport during intraperitoneal chemotherapy},
  year         = {2016},
}