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The link between obstructive sleep apnea and cardiovascular disease

Fre Bauters (UGent) , Ernst Rietzschel (UGent) , Katrien Hertegonne (UGent) and Julio Chirinos Medina (UGent)
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Organization
Abstract
Obstructive sleep apnea (OSA) is common in the general population and highly prevalent in patients with cardiovascular disease. In this paper, we review (1) the pathophysiological mechanisms of OSA that may causally contribute to cardiovascular disease; (2) current evidence regarding the association between OSA and hypertension, stroke, ischemic heart disease, heart failure, atrial fibrillation, and cardiovascular mortality; and (3) the impact of continuous positive airway pressure (CPAP) treatment on cardiovascular risk factors and outcomes. We emphasize the importance of obesity as a comorbidity of OSA and a confounder in the association between OSA and cardiovascular disease. We also discuss the importance of addressing obesity in patients with OSA, as a strategy to reduce the burden of cardiovascular risk factors in this population. Implications for the approach of patients' OSA in clinical practice and future research directions are discussed.
Keywords
Continuous positive airway pressure, Hypertension, CHRONIC HEART-FAILURE, C-REACTIVE PROTEIN, TERM-FOLLOW-UP, ENDOTHELIAL FUNCTION, Inflammation, POSITIVE AIRWAY PRESSURE, RANDOMIZED CONTROLLED-TRIAL, CORONARY-ARTERY-DISEASE, ATRIAL-FIBRILLATION RECURRENCE, ACUTE MYOCARDIAL-INFARCTION, INDEPENDENT RISK-FACTOR, Obesity, Cardiovascular disease, Obstructive sleep apnea

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Please use this url to cite or link to this publication:

MLA
Bauters, Fre et al. “The Link Between Obstructive Sleep Apnea and Cardiovascular Disease.” CURRENT ATHEROSCLEROSIS REPORTS 18.1 (2016): n. pag. Print.
APA
Bauters, F., Rietzschel, E., Hertegonne, K., & Chirinos Medina, J. (2016). The link between obstructive sleep apnea and cardiovascular disease. CURRENT ATHEROSCLEROSIS REPORTS, 18(1).
Chicago author-date
Bauters, Fre, Ernst Rietzschel, Katrien Hertegonne, and Julio Chirinos Medina. 2016. “The Link Between Obstructive Sleep Apnea and Cardiovascular Disease.” Current Atherosclerosis Reports 18 (1).
Chicago author-date (all authors)
Bauters, Fre, Ernst Rietzschel, Katrien Hertegonne, and Julio Chirinos Medina. 2016. “The Link Between Obstructive Sleep Apnea and Cardiovascular Disease.” Current Atherosclerosis Reports 18 (1).
Vancouver
1.
Bauters F, Rietzschel E, Hertegonne K, Chirinos Medina J. The link between obstructive sleep apnea and cardiovascular disease. CURRENT ATHEROSCLEROSIS REPORTS. 2016;18(1).
IEEE
[1]
F. Bauters, E. Rietzschel, K. Hertegonne, and J. Chirinos Medina, “The link between obstructive sleep apnea and cardiovascular disease,” CURRENT ATHEROSCLEROSIS REPORTS, vol. 18, no. 1, 2016.
@article{8134167,
  abstract     = {{Obstructive sleep apnea (OSA) is common in the general population and highly prevalent in patients with cardiovascular disease. In this paper, we review (1) the pathophysiological mechanisms of OSA that may causally contribute to cardiovascular disease; (2) current evidence regarding the association between OSA and hypertension, stroke, ischemic heart disease, heart failure, atrial fibrillation, and cardiovascular mortality; and (3) the impact of continuous positive airway pressure (CPAP) treatment on cardiovascular risk factors and outcomes. We emphasize the importance of obesity as a comorbidity of OSA and a confounder in the association between OSA and cardiovascular disease. We also discuss the importance of addressing obesity in patients with OSA, as a strategy to reduce the burden of cardiovascular risk factors in this population. Implications for the approach of patients' OSA in clinical practice and future research directions are discussed.}},
  articleno    = {{1}},
  author       = {{Bauters, Fre and Rietzschel, Ernst and Hertegonne, Katrien and Chirinos Medina, Julio}},
  issn         = {{1523-3804}},
  journal      = {{CURRENT ATHEROSCLEROSIS REPORTS}},
  keywords     = {{Continuous positive airway pressure,Hypertension,CHRONIC HEART-FAILURE,C-REACTIVE PROTEIN,TERM-FOLLOW-UP,ENDOTHELIAL FUNCTION,Inflammation,POSITIVE AIRWAY PRESSURE,RANDOMIZED CONTROLLED-TRIAL,CORONARY-ARTERY-DISEASE,ATRIAL-FIBRILLATION RECURRENCE,ACUTE MYOCARDIAL-INFARCTION,INDEPENDENT RISK-FACTOR,Obesity,Cardiovascular disease,Obstructive sleep apnea}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{The link between obstructive sleep apnea and cardiovascular disease}},
  url          = {{http://dx.doi.org/10.1007/s11883-015-0556-z}},
  volume       = {{18}},
  year         = {{2016}},
}

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