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Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam study

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Abstract
COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (Rotterdam Study) enrolling subjects aged aeyen45, COPD was diagnosed based on a pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). In absence of an interpretable spirometry within the Rotterdam Study, cases were defined as having COPD diagnosed by a physician on the basis of clinical presentation and obstructive lung function measured by the general practitioner or respiratory physician. Incidence rates were calculated by dividing the number of incident cases by the total number of person years of subjects at risk. In this cohort of 14,619 participants, 1993 subjects with COPD were identified of whom 689 as prevalent ones and 1304 cases as incident ones. The overall incidence rate (IR) of COPD was 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4-9.4. The IR was higher in males and in smokers. The proportion of female COPD participants without a history of smoking was 27.2 %, while this proportion was 7.3 % in males. The prevalence of COPD in the Rotterdam Study is 4.7 % and the overall incidence is approximately 9/1000 PY, with a higher incidence in males and in smokers. The proportion of never-smokers among female COPD cases is substantial.
Keywords
The Rotterdam Study, OBSTRUCTIVE PULMONARY-DISEASE, Prevalence, Incidence, LLN, GOLD, COPD, PASSIVE SMOKING EXPOSURE, NEVER-SMOKERS, SYSTEMATIC ANALYSIS, GLOBAL BURDEN, DESIGN UPDATE, LUNG-FUNCTION, POPULATION, RISK, MORTALITY

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Chicago
Terzikhan, Natalie, Katia MC Verhamme, Albert Hofman, Bruno H Stricker, Guy Brusselle, and Lies Lahousse. 2016. “Prevalence and Incidence of COPD in Smokers and Non-smokers: The Rotterdam Study.” European Journal of Epidemiology 31 (8): 785–792.
APA
Terzikhan, N., Verhamme, K. M., Hofman, A., Stricker, B. H., Brusselle, G., & Lahousse, L. (2016). Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam study. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 31(8), 785–792.
Vancouver
1.
Terzikhan N, Verhamme KM, Hofman A, Stricker BH, Brusselle G, Lahousse L. Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam study. EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2016;31(8):785–92.
MLA
Terzikhan, Natalie et al. “Prevalence and Incidence of COPD in Smokers and Non-smokers: The Rotterdam Study.” EUROPEAN JOURNAL OF EPIDEMIOLOGY 31.8 (2016): 785–792. Print.
@article{8133739,
  abstract     = {COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (Rotterdam Study) enrolling subjects aged aeyen45, COPD was diagnosed based on a pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). In absence of an interpretable spirometry within the Rotterdam Study, cases were defined as having COPD diagnosed by a physician on the basis of clinical presentation and obstructive lung function measured by the general practitioner or respiratory physician. Incidence rates were calculated by dividing the number of incident cases by the total number of person years of subjects at risk. In this cohort of 14,619 participants, 1993 subjects with COPD were identified of whom 689 as prevalent ones and 1304 cases as incident ones. The overall incidence rate (IR) of COPD was 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4-9.4. The IR was higher in males and in smokers. The proportion of female COPD participants without a history of smoking was 27.2 %, while this proportion was 7.3 % in males. The prevalence of COPD in the Rotterdam Study is 4.7 % and the overall incidence is approximately 9/1000 PY, with a higher incidence in males and in smokers. The proportion of never-smokers among female COPD cases is substantial.},
  author       = {Terzikhan, Natalie and Verhamme, Katia MC and Hofman, Albert and Stricker, Bruno H and Brusselle, Guy and Lahousse, Lies},
  issn         = {0393-2990},
  journal      = {EUROPEAN JOURNAL OF EPIDEMIOLOGY},
  keywords     = {The Rotterdam Study,OBSTRUCTIVE PULMONARY-DISEASE,Prevalence,Incidence,LLN,GOLD,COPD,PASSIVE SMOKING EXPOSURE,NEVER-SMOKERS,SYSTEMATIC ANALYSIS,GLOBAL BURDEN,DESIGN UPDATE,LUNG-FUNCTION,POPULATION,RISK,MORTALITY},
  language     = {eng},
  number       = {8},
  pages        = {785--792},
  title        = {Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam study},
  url          = {http://dx.doi.org/10.1007/s10654-016-0132-z},
  volume       = {31},
  year         = {2016},
}

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