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Strategic down-regulation of attentional resources as a mechanism of proactive response inhibition

Zachary Langford (UGent) , Ruth Krebs (UGent) , Durk Talsma (UGent) , MG Woldorff and Nico Böhler (UGent)
(2016) EUROPEAN JOURNAL OF NEUROSCIENCE. 44(4). p.2095-2103
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Abstract
Efficiently avoiding inappropriate actions in a changing environment is central to cognitive control. One mechanism contributing to this ability is the deliberate slowing down of responses in contexts where full response cancellation might occasionally be required, referred to as proactive response inhibition. The present electroencephalographic (EEG) study investigated the role of attentional processes in proactive response inhibition in humans. To this end, we compared data from a standard stop-signal task, in which stop signals required response cancellation (stop-relevant'), to data where possible stop signals were task-irrelevant (stop-irrelevant'). Behavioral data clearly indicated the presence of proactive slowing in the standard stop-signal task. A novel single-trial analysis was used to directly model the relationship between response time and the EEG data of the go-trials in both contexts within a multilevel linear models framework. We found a relationship between response time and amplitude of the attention-related N1 component in stop-relevant blocks, a characteristic that was fully absent in stop-irrelevant blocks. Specifically, N1 amplitudes were lower the slower the response time, suggesting that attentional resources were being strategically down-regulated to control response speed. Drift diffusion modeling of the behavioral data indicated that multiple parameters differed across the two contexts, likely suggesting the contribution from independent brain mechanisms to proactive slowing. Hence, the attentional mechanism of proactive response control we report here might coexist with known mechanisms that are more directly tied to motoric response inhibition. As such, our study opens up new research avenues also concerning clinical conditions that feature deficits in proactive response inhibition.
Keywords
INFERIOR FRONTAL-CORTEX, CONNECTIVITY, STOP-SIGNAL TASK, ADJUSTMENTS, NEURAL BASIS, MODEL, SUPPRESSION, PERFORMANCE, COMPONENT, NETWORKS, attention, drift diffusion models, proactive control, response inhibition, single-trial EEG

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Citation

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Chicago
Langford, Zachary, Ruth Krebs, Durk Talsma, MG Woldorff, and Nico Böhler. 2016. “Strategic Down-regulation of Attentional Resources as a Mechanism of Proactive Response Inhibition.” European Journal of Neuroscience 44 (4): 2095–2103.
APA
Langford, Z., Krebs, R., Talsma, D., Woldorff, M., & Böhler, N. (2016). Strategic down-regulation of attentional resources as a mechanism of proactive response inhibition. EUROPEAN JOURNAL OF NEUROSCIENCE, 44(4), 2095–2103.
Vancouver
1.
Langford Z, Krebs R, Talsma D, Woldorff M, Böhler N. Strategic down-regulation of attentional resources as a mechanism of proactive response inhibition. EUROPEAN JOURNAL OF NEUROSCIENCE. 2016;44(4):2095–103.
MLA
Langford, Zachary, Ruth Krebs, Durk Talsma, et al. “Strategic Down-regulation of Attentional Resources as a Mechanism of Proactive Response Inhibition.” EUROPEAN JOURNAL OF NEUROSCIENCE 44.4 (2016): 2095–2103. Print.
@article{8132860,
  abstract     = {Efficiently avoiding inappropriate actions in a changing environment is central to cognitive control. One mechanism contributing to this ability is the deliberate slowing down of responses in contexts where full response cancellation might occasionally be required, referred to as proactive response inhibition. The present electroencephalographic (EEG) study investigated the role of attentional processes in proactive response inhibition in humans. To this end, we compared data from a standard stop-signal task, in which stop signals required response cancellation (stop-relevant'), to data where possible stop signals were task-irrelevant (stop-irrelevant'). Behavioral data clearly indicated the presence of proactive slowing in the standard stop-signal task. A novel single-trial analysis was used to directly model the relationship between response time and the EEG data of the go-trials in both contexts within a multilevel linear models framework. We found a relationship between response time and amplitude of the attention-related N1 component in stop-relevant blocks, a characteristic that was fully absent in stop-irrelevant blocks. Specifically, N1 amplitudes were lower the slower the response time, suggesting that attentional resources were being strategically down-regulated to control response speed. Drift diffusion modeling of the behavioral data indicated that multiple parameters differed across the two contexts, likely suggesting the contribution from independent brain mechanisms to proactive slowing. Hence, the attentional mechanism of proactive response control we report here might coexist with known mechanisms that are more directly tied to motoric response inhibition. As such, our study opens up new research avenues also concerning clinical conditions that feature deficits in proactive response inhibition.},
  author       = {Langford, Zachary and Krebs, Ruth and Talsma, Durk and Woldorff, MG and B{\"o}hler, Nico},
  issn         = {0953-816X},
  journal      = {EUROPEAN JOURNAL OF NEUROSCIENCE},
  language     = {eng},
  number       = {4},
  pages        = {2095--2103},
  title        = {Strategic down-regulation of attentional resources as a mechanism of proactive response inhibition},
  url          = {http://dx.doi.org/10.1111/ejn.13303},
  volume       = {44},
  year         = {2016},
}

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