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An evolutionary perspective on the necroptotic pathway

Yves Dondelinger (UGent) , Paco Hulpiau (UGent) , Yvan Saeys (UGent) , Mathieu Bertrand (UGent) and Peter Vandenabeele (UGent)
(2016) TRENDS IN CELL BIOLOGY. 26(10). p.721-732
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Abstract
Throughout the animal kingdom, innate immune receptors protect the organism from microbial intruders by activating pathways that mediate inflammation and pathogen clearance. Necroptosis contributes to the innate immune response by killing pathogen-infected cells and by alerting the immune system through the release of danger signals. Components of the necroptotic signaling axis - TIR-domain-containing adapter-inducing interferon-beta (TRIP), Z-DNA sensor DAI, receptor-interacting kinase (RIPK)1, RIPK3 and mixed-lineage kinase domain-like protein (MLKL) - are therefore expected to be found in all animals. However, a phylogenetic analysis reveals that the necroptotic axis, except for RIPK1, is poorly conserved in the animal kingdom, suggesting that alternative mechanisms regulate necroptosis in these species or that necroptosis would apparently be absent. These findings question the universal role of necroptosis during innate immunity in the animal kingdom.
Keywords
NF-KAPPA-B, MIXED LINEAGE KINASE, HOMOTYPIC INTERACTION MOTIF, DOMAIN-LIKE PROTEIN, PROGRAMMED CELL-DEATH, TNF-INDUCED APOPTOSIS, HETEROKARYON INCOMPATIBILITY, SIGNALING PATHWAYS, IMMUNE-RESPONSE, ACTIVATION LOOP

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Chicago
Dondelinger, Yves, Paco Hulpiau, Yvan Saeys, Mathieu Bertrand, and Peter Vandenabeele. 2016. “An Evolutionary Perspective on the Necroptotic Pathway.” Trends in Cell Biology 26 (10): 721–732.
APA
Dondelinger, Y., Hulpiau, P., Saeys, Y., Bertrand, M., & Vandenabeele, P. (2016). An evolutionary perspective on the necroptotic pathway. TRENDS IN CELL BIOLOGY, 26(10), 721–732.
Vancouver
1.
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand M, Vandenabeele P. An evolutionary perspective on the necroptotic pathway. TRENDS IN CELL BIOLOGY. 2016;26(10):721–32.
MLA
Dondelinger, Yves et al. “An Evolutionary Perspective on the Necroptotic Pathway.” TRENDS IN CELL BIOLOGY 26.10 (2016): 721–732. Print.
@article{8132691,
  abstract     = {Throughout the animal kingdom, innate immune receptors protect the organism from microbial intruders by activating pathways that mediate inflammation and pathogen clearance. Necroptosis contributes to the innate immune response by killing pathogen-infected cells and by alerting the immune system through the release of danger signals. Components of the necroptotic signaling axis - TIR-domain-containing adapter-inducing interferon-beta (TRIP), Z-DNA sensor DAI, receptor-interacting kinase (RIPK)1, RIPK3 and mixed-lineage kinase domain-like protein (MLKL) - are therefore expected to be found in all animals. However, a phylogenetic analysis reveals that the necroptotic axis, except for RIPK1, is poorly conserved in the animal kingdom, suggesting that alternative mechanisms regulate necroptosis in these species or that necroptosis would apparently be absent. These findings question the universal role of necroptosis during innate immunity in the animal kingdom.},
  author       = {Dondelinger, Yves and Hulpiau, Paco and Saeys, Yvan and Bertrand, Mathieu and Vandenabeele, Peter},
  issn         = {0962-8924},
  journal      = {TRENDS IN CELL BIOLOGY},
  keywords     = {NF-KAPPA-B,MIXED LINEAGE KINASE,HOMOTYPIC INTERACTION MOTIF,DOMAIN-LIKE PROTEIN,PROGRAMMED CELL-DEATH,TNF-INDUCED APOPTOSIS,HETEROKARYON INCOMPATIBILITY,SIGNALING PATHWAYS,IMMUNE-RESPONSE,ACTIVATION LOOP},
  language     = {eng},
  number       = {10},
  pages        = {721--732},
  title        = {An evolutionary perspective on the necroptotic pathway},
  url          = {http://dx.doi.org/10.1016/j.tcb.2016.06.004},
  volume       = {26},
  year         = {2016},
}

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