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Cellular functions of optineurin in health and disease

Karolina Slowicka (UGent) , Lars Vereecke (UGent) and Geert van Loo (UGent)
(2016) TRENDS IN IMMUNOLOGY. 37(9). p.621-633
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Abstract
Optineurin (OPTN) was initially identified as a regulator of NF-kappa B and interferon signaling, but attracted most attention because of its association with various human disorders such as glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis. Importantly, OPTN has recently been identified as an autophagy receptor important for the autophagic removal of pathogens, damaged mitochondria, and protein aggregates. This activity is most likely compromised in patients carrying OPTN mutations, and contributes to the observed phenotypes. In this review we summarize recent studies describing the molecular mechanisms by which OPTN controls immunity and autophagy, and discuss these findings in the context of several diseases that have been associated with OPTN (mal)function.
Keywords
NECROSIS-FACTOR-ALPHA, OPEN-ANGLE GLAUCOMA, NF-KAPPA-B, AMYOTROPHIC-LATERAL-SCLEROSIS, AUTOPHAGY RECEPTOR OPTINEURIN, RETINAL GANGLION-CELLS, MYOSIN-VI, SELECTIVE AUTOPHAGY, PAGETS-DISEASE, CYTOKINE SECRETION

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Chicago
Slowicka, Karolina, Lars Vereecke, and Geert van Loo. 2016. “Cellular Functions of Optineurin in Health and Disease.” Trends in Immunology 37 (9): 621–633.
APA
Slowicka, K., Vereecke, L., & van Loo, G. (2016). Cellular functions of optineurin in health and disease. TRENDS IN IMMUNOLOGY, 37(9), 621–633.
Vancouver
1.
Slowicka K, Vereecke L, van Loo G. Cellular functions of optineurin in health and disease. TRENDS IN IMMUNOLOGY. 2016;37(9):621–33.
MLA
Slowicka, Karolina, Lars Vereecke, and Geert van Loo. “Cellular Functions of Optineurin in Health and Disease.” TRENDS IN IMMUNOLOGY 37.9 (2016): 621–633. Print.
@article{8132545,
  abstract     = {Optineurin (OPTN) was initially identified as a regulator of NF-kappa B and interferon signaling, but attracted most attention because of its association with various human disorders such as glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis. Importantly, OPTN has recently been identified as an autophagy receptor important for the autophagic removal of pathogens, damaged mitochondria, and protein aggregates. This activity is most likely compromised in patients carrying OPTN mutations, and contributes to the observed phenotypes. In this review we summarize recent studies describing the molecular mechanisms by which OPTN controls immunity and autophagy, and discuss these findings in the context of several diseases that have been associated with OPTN (mal)function.},
  author       = {Slowicka, Karolina and Vereecke, Lars and van Loo, Geert},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  language     = {eng},
  number       = {9},
  pages        = {621--633},
  title        = {Cellular functions of optineurin in health and disease},
  url          = {http://dx.doi.org/10.1016/j.it.2016.07.002},
  volume       = {37},
  year         = {2016},
}

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