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Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection

(2008) JOURNAL OF INFECTIOUS DISEASES. 198(9). p.1284-1291
Author
Organization
Abstract
To determine the immunological role played by interleukin (IL)-12 family members in Trypanosoma congolense infection, IL-12p35(-/-), IL-12p40(-/-), and IL-12p35(/-/-)p40(-/-) mice were used. While the latter 2 strains lack all IL-12 homologues, IL-12p35m(-/-) ice still produce IL-12p80 homodimers and IL-23. Compared with wild-type mice, all infected IL-12-deficient mouse strains showed prolonged survival, whereas parasitemia levels were unaltered. Interferon (IFN)-gamma production in IL-12-deficient mice was strikingly reduced during the acute and chronic stages of infection, coinciding with significantly reduced chronic-stage hepatocellular damage, as demonstrated by histological analysis and plasma aspartate transaminase measurements. In contrast, IL-10 production was not affected by the absence of IL-12. Taken together, these results show that, during T. congolense infection, the absence of IL-12, but not the IL-12p80 homodimer or IL-23, leads to a reduction in IFN-gamma production, which reduces hepatic pathology and improves host survival in conjunction with IL-10 without negatively affecting parasitemia control.
Keywords
EXPERIMENTAL AFRICAN TRYPANOSOMIASIS, TYPE-1 CYTOKINE RESPONSES, NECROSIS-FACTOR-ALPHA, IL-12-DEFICIENT MICE, NITRIC-OXIDE, ANTIBODY-RESPONSES, INTERFERON-GAMMA, CELLS, RESISTANCE, IL-12

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Chicago
Barkhuizen, Mark, Stefan Magez, Bernhard Ryffel, and Frank Brombacher. 2008. “Interleukin-12p70 Deficiency Increases Survival and Diminishes Pathology in Trypanosoma Congolense Infection.” Journal of Infectious Diseases 198 (9): 1284–1291.
APA
Barkhuizen, M., Magez, S., Ryffel, B., & Brombacher, F. (2008). Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection. JOURNAL OF INFECTIOUS DISEASES, 198(9), 1284–1291.
Vancouver
1.
Barkhuizen M, Magez S, Ryffel B, Brombacher F. Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection. JOURNAL OF INFECTIOUS DISEASES. 2008;198(9):1284–91.
MLA
Barkhuizen, Mark et al. “Interleukin-12p70 Deficiency Increases Survival and Diminishes Pathology in Trypanosoma Congolense Infection.” JOURNAL OF INFECTIOUS DISEASES 198.9 (2008): 1284–1291. Print.
@article{8131916,
  abstract     = {To determine the immunological role played by interleukin (IL)-12 family members in Trypanosoma congolense infection, IL-12p35(-/-), IL-12p40(-/-), and IL-12p35(/-/-)p40(-/-) mice were used. While the latter 2 strains lack all IL-12 homologues, IL-12p35m(-/-) ice still produce IL-12p80 homodimers and IL-23. Compared with wild-type mice, all infected IL-12-deficient mouse strains showed prolonged survival, whereas parasitemia levels were unaltered. Interferon (IFN)-gamma production in IL-12-deficient mice was strikingly reduced during the acute and chronic stages of infection, coinciding with significantly reduced chronic-stage hepatocellular damage, as demonstrated by histological analysis and plasma aspartate transaminase measurements. In contrast, IL-10 production was not affected by the absence of IL-12. Taken together, these results show that, during T. congolense infection, the absence of IL-12, but not the IL-12p80 homodimer or IL-23, leads to a reduction in IFN-gamma production, which reduces hepatic pathology and improves host survival in conjunction with IL-10 without negatively affecting parasitemia control.},
  author       = {Barkhuizen, Mark and Magez, Stefan and Ryffel, Bernhard and Brombacher, Frank},
  issn         = {1537-6613},
  journal      = {JOURNAL OF INFECTIOUS DISEASES},
  language     = {eng},
  number       = {9},
  pages        = {1284--1291},
  title        = {Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection},
  url          = {http://dx.doi.org/10.1086/592048},
  volume       = {198},
  year         = {2008},
}

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