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Vaccination against trypanosomiasis : can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?

(2011) HUMAN VACCINES. 7(11). p.1225-1233
Author
Organization
Abstract
To date, human African trypanosomiasis (HAT) still threatens millions of people throughout sub-Sahara Africa, and new approaches to disease prevention and treatment remain a priority. It is commonly accepted that HAT is fatal unless treatment is provided. However, despite the well-described general symptoms of disease progression during distinct stages of the infection, leading to encephalitic complications, coma and death, a substantial body of evidence has been reported suggesting that natural acquired immunity could occur. Hence, if under favorable conditions natural infections can lead to correct immune activation and immune protection against HAT, the development of an effective anti-HAT vaccine should remain a central goal in the fight against this disease. In this review, we will (1) discuss the vaccine candidates that have been proposed over the past years, (2) highlight the main obstacles that an efficient anti-trypanosomiasis vaccine needs to overcome and (3) critically reflect on the validity of the widely used murine model for HAT.
Keywords
sleeping sickness, vaccination, antigenic variation, dyslymphopoiesis, animal model, immune memory, TUMOR-NECROSIS-FACTOR, HUMAN AFRICAN TRYPANOSOMIASIS, INVARIANT SURFACE GLYCOPROTEINS, B.-BRUCEI INFECTION, SLEEPING-SICKNESS, FLAGELLAR POCKET, INTERFERON-GAMMA, HUMAN-SERUM, MECHANICAL TRANSMISSION, CYSTEINE PROTEINASES

Citation

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Chicago
La Greca, Florencia, and Stefan Magez. 2011. “Vaccination Against Trypanosomiasis : Can It Be Done or Is the Trypanosome Truly the Ultimate Immune Destroyer and Escape Artist?” Human Vaccines 7 (11): 1225–1233.
APA
La Greca, F., & Magez, S. (2011). Vaccination against trypanosomiasis : can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist? HUMAN VACCINES, 7(11), 1225–1233.
Vancouver
1.
La Greca F, Magez S. Vaccination against trypanosomiasis : can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist? HUMAN VACCINES. 2011;7(11):1225–33.
MLA
La Greca, Florencia, and Stefan Magez. “Vaccination Against Trypanosomiasis : Can It Be Done or Is the Trypanosome Truly the Ultimate Immune Destroyer and Escape Artist?” HUMAN VACCINES 7.11 (2011): 1225–1233. Print.
@article{8131798,
  abstract     = {To date, human African trypanosomiasis (HAT) still threatens millions of people throughout sub-Sahara Africa, and new approaches to disease prevention and treatment remain a priority. It is commonly accepted that HAT is fatal unless treatment is provided. However, despite the well-described general symptoms of disease progression during distinct stages of the infection, leading to encephalitic complications, coma and death, a substantial body of evidence has been reported suggesting that natural acquired immunity could occur. Hence, if under favorable conditions natural infections can lead to correct immune activation and immune protection against HAT, the development of an effective anti-HAT vaccine should remain a central goal in the fight against this disease. 
In this review, we will (1) discuss the vaccine candidates that have been proposed over the past years, (2) highlight the main obstacles that an efficient anti-trypanosomiasis vaccine needs to overcome and (3) critically reflect on the validity of the widely used murine model for HAT.},
  author       = {La Greca, Florencia and Magez, Stefan},
  issn         = {1554-8600},
  journal      = {HUMAN VACCINES},
  language     = {eng},
  number       = {11},
  pages        = {1225--1233},
  title        = {Vaccination against trypanosomiasis : can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?},
  url          = {http://dx.doi.org/10.4161/hv.7.11.18203},
  volume       = {7},
  year         = {2011},
}

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