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Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity

Author
Organization
Abstract
The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictly extracellular protozoan parasites are confronted with different arms of the host's immune response (cellular as well as humoral) and via an elaborate and efficient (vector)-parasite-host interplay they have evolved efficient immune escape mechanisms to evade/manipulate the entire host immune response. This is of importance, since these parasites need to survive sufficiently long in their mammalian/vector host in order to complete their life cycle/transmission. Here, we will give an overview of the different mechanisms AT (i.e. T. brucei as a model organism) employ, comprising both tsetse fly saliva and parasite-derived components to modulate host innate immune responses thereby sculpturing an environment that allows survival and development within the mammalian host.
Keywords
African trypanosomosis, T. brucei, tsetse fly, innate immune response, pathogenicity, VARIANT SURFACE GLYCOPROTEIN, TUMOR-NECROSIS-FACTOR, LYMPHOCYTE-TRIGGERING FACTOR, GLOSSINA-MORSITANS-MORSITANS, HAPTOGLOBIN-HEMOGLOBIN RECEPTOR, HUMAN AFRICAN TRYPANOSOMIASIS, ARTHROPOD-BORNE PATHOGENS, TSETSE THROMBIN INHIBITOR, HIGH-DENSITY-LIPOPROTEIN, FLY SALIVARY-GLANDS

Citation

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MLA
Stijlemans, Benoit, Guy Caljon, Jan Van den Abbeele, et al. “Immune Evasion Strategies of Trypanosoma Brucei Within the Mammalian Host : Progression to Pathogenicity.” FRONTIERS IN IMMUNOLOGY 7 (2016): n. pag. Print.
APA
Stijlemans, Benoit, Caljon, G., Van den Abbeele, J., Van Ginderachter, J. A., Magez, S., & De Trez, C. (2016). Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity. FRONTIERS IN IMMUNOLOGY, 7.
Chicago author-date
Stijlemans, Benoit, Guy Caljon, Jan Van den Abbeele, Jo A Van Ginderachter, Stefan Magez, and Carl De Trez. 2016. “Immune Evasion Strategies of Trypanosoma Brucei Within the Mammalian Host : Progression to Pathogenicity.” Frontiers in Immunology 7.
Chicago author-date (all authors)
Stijlemans, Benoit, Guy Caljon, Jan Van den Abbeele, Jo A Van Ginderachter, Stefan Magez, and Carl De Trez. 2016. “Immune Evasion Strategies of Trypanosoma Brucei Within the Mammalian Host : Progression to Pathogenicity.” Frontiers in Immunology 7.
Vancouver
1.
Stijlemans B, Caljon G, Van den Abbeele J, Van Ginderachter JA, Magez S, De Trez C. Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity. FRONTIERS IN IMMUNOLOGY. 2016;7.
IEEE
[1]
B. Stijlemans, G. Caljon, J. Van den Abbeele, J. A. Van Ginderachter, S. Magez, and C. De Trez, “Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity,” FRONTIERS IN IMMUNOLOGY, vol. 7, 2016.
@article{8131526,
  abstract     = {The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictly extracellular protozoan parasites are confronted with different arms of the host's immune response (cellular as well as humoral) and via an elaborate and efficient (vector)-parasite-host interplay they have evolved efficient immune escape mechanisms to evade/manipulate the entire host immune response. This is of importance, since these parasites need to survive sufficiently long in their mammalian/vector host in order to complete their life cycle/transmission. Here, we will give an overview of the different mechanisms AT (i.e. T. brucei as a model organism) employ, comprising both tsetse fly saliva and parasite-derived components to modulate host innate immune responses thereby sculpturing an environment that allows survival and development within the mammalian host.},
  articleno    = {233},
  author       = {Stijlemans, Benoit and Caljon, Guy and Van den Abbeele, Jan and Van Ginderachter, Jo A and Magez, Stefan and De Trez, Carl},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keywords     = {African trypanosomosis,T. brucei,tsetse fly,innate immune response,pathogenicity,VARIANT SURFACE GLYCOPROTEIN,TUMOR-NECROSIS-FACTOR,LYMPHOCYTE-TRIGGERING FACTOR,GLOSSINA-MORSITANS-MORSITANS,HAPTOGLOBIN-HEMOGLOBIN RECEPTOR,HUMAN AFRICAN TRYPANOSOMIASIS,ARTHROPOD-BORNE PATHOGENS,TSETSE THROMBIN INHIBITOR,HIGH-DENSITY-LIPOPROTEIN,FLY SALIVARY-GLANDS},
  language     = {eng},
  pages        = {14},
  title        = {Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity},
  url          = {http://dx.doi.org/10.3389/fimmu.2016.00233},
  volume       = {7},
  year         = {2016},
}

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