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Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

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Abstract
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Keywords
INTENSIVE-CARE-UNIT, SPECTRUM-BETA-LACTAMASE, CRITICALLY-ILL PATIENTS, GRAM-NEGATIVE BACTERIA, VANCOMYCIN-RESISTANT ENTEROCOCCI, CLOSTRIDIUM-DIFFICILE INFECTION, VENTILATOR-ASSOCIATED PNEUMONIA, BLOOD-STREAM INFECTIONS, CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, CLINICAL-PRACTICE GUIDELINES

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Citation

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Chicago
Sartelli, M, DG Weber, E Ruppe, M Bassetti, BJ Wright, L Ansaloni, F Catena, et al. 2016. “Antimicrobials : a Global Alliance for Optimizing Their Rational Use in Intra-abdominal Infections (AGORA).” World Journal of Emergency Surgery 11.
APA
Sartelli, M, Weber, D., Ruppe, E., Bassetti, M., Wright, B., Ansaloni, L., Catena, F., et al. (2016). Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). WORLD JOURNAL OF EMERGENCY SURGERY, 11.
Vancouver
1.
Sartelli M, Weber D, Ruppe E, Bassetti M, Wright B, Ansaloni L, et al. Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). WORLD JOURNAL OF EMERGENCY SURGERY. 2016;11.
MLA
Sartelli, M, DG Weber, E Ruppe, et al. “Antimicrobials : a Global Alliance for Optimizing Their Rational Use in Intra-abdominal Infections (AGORA).” WORLD JOURNAL OF EMERGENCY SURGERY 11 (2016): n. pag. Print.
@article{8128025,
  abstract     = {Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. 
The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. 
The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. 
An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.},
  articleno    = {33},
  author       = {Sartelli, M and Weber, DG and Ruppe, E and Bassetti, M and Wright, BJ and Ansaloni, L and Catena, F and Coccolini, F and Abu-Zidan, FM and Coimbra, R and Moore, EE and Moore, FA and Maier, RV and De Waele, Jan and Kirkpatrick, AW and Griffiths, EA and Eckmann, C and Brink, AJ and Mazuski, JE and May, AK and Sawyer, RG and Mertz, D and Montravers, P and Kumar, A and Roberts, JA and Vincent, JL and Watkins, RR and Lowman, W and Spellberg, B and Abbott, IJ and Adesunkanmi, AK and Al-Dahir, S and Al-Hasan, MN and Agresta, F and Althani, AA and Ansari, S and Ansumana, R and Augustin, G and Bala, M and Balogh, ZJ and Baraket, O and Bhangu, A and Beltran, MA and Bernhard, M and Biffl, WL and Boermeester, MA and Brecher, SM and Cherry-Bukowiec, JR and Buyne, OR and Cainzos, MA and Cairns, KA and Camacho-Ortiz, A and Chandy, SJ and Jusoh, AC and Chichom-Mefire, A and Colijn, C and Corcione, F and Cui, YF and Curcio, D and Delibegovic, S and Demetrashvili, Z and De Simone, B and Dhingra, S and Diaz, JJ and Di Carlo, I and Dillip, A and Di Saverio, S and Doyle, MP and Dorj, G and Dogjani, A and Dupont, H and Eachempati, SR and Enani, MA and Egiev, VN and Elmangory, MM and Ferrada, P and Fitchett, JR and Fraga, GP and Guessennd, N and Giamarellou, H and Ghnnam, W and Gkiokas, G and Goldberg, SR and Gomes, CA and Gomi, H and Guzman-Blanco, M and Haque, M and Hansen, S and Hecker, A and Heizmann, WR and Herzog, T and Hodonou, AM and Hong, SK and Kafka-Ritsch, R and Kaplan, LJ and Kapoor, G and Karamarkovic, A and Kees, MG and Kenig, J and Kiguba, R and Kim, PK and Kluger, Y and Khokha, V and Koike, K and Kok, KYY and Kong, V and Knox, MC and Inaba, K and Isik, A and Iskandar, K and Ivatury, RR and Labbate, M and Labricciosa, FM and Laterre, PF and Latifi, R and Lee, JG and Lee, YR and Leone, M and Leppaniemi, A and Li, YS and Liang, SY and Loho, T and Maegele, M and Malama, S and Marei, HE and Martin-Loeches, I and Marwah, S and Massele, A and McFarlane, M and Melo, RB and Negoi, I and Nicolau, DP and Nord, CE and Ofori-Asenso, R and Omari, AH and Ordonez, CA and Ouadii, M and Pereira, GA and Piazza, D and Pupelis, G and Rawson, TM and Rems, M and Rizoli, S and Rocha, C and Sakakhushev, B and Sanchez-Garcia, M and Sato, N and Lohse, HAS and Sganga, G and Siribumrungwong, B and Shelat, VG and Soreide, K and Soto, R and Talving, P and Tilsed, JV and Timsit, JF and Trueba, G and Trung, NT and Ulrych, J and van Goor, H and Vereczkei, A and Vohra, RS and Wani, I and Uhl, W and Xiao, YH and Yuan, KC and Zachariah, SK and Zahar, JR and Zakrison, TL and Corcione, A and Melotti, RM and Viscoli, C and Viale, P},
  issn         = {1749-7922},
  journal      = {WORLD JOURNAL OF EMERGENCY SURGERY},
  keyword      = {INTENSIVE-CARE-UNIT,SPECTRUM-BETA-LACTAMASE,CRITICALLY-ILL PATIENTS,GRAM-NEGATIVE BACTERIA,VANCOMYCIN-RESISTANT ENTEROCOCCI,CLOSTRIDIUM-DIFFICILE INFECTION,VENTILATOR-ASSOCIATED PNEUMONIA,BLOOD-STREAM INFECTIONS,CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE,CLINICAL-PRACTICE GUIDELINES},
  language     = {eng},
  pages        = {32},
  title        = {Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)},
  url          = {http://dx.doi.org/10.1186/s13017-016-0089-y},
  volume       = {11},
  year         = {2016},
}

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