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Abstract
Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration. Despite the wealth of knowledge regarding the involvement of cellular communication in inflammation, studies on the role of connexin-based channels in this process have only begun to emerge in the last few years. In this paper, a state-of-the-art overview of the effects of inflammation on connexin signaling is provided. Vice versa, the involvement of connexins and their channels in inflammation will be discussed by relying on studies that use a variety of experimental tools, such as genetically modified animals, small interfering RNA and connexin-based channel blockers. A better understanding of the importance of connexin signaling in inflammation may open up towards clinical perspectives.
Keywords
Connexins, gap junctions, hemichannels, inflammation, cytokines, GAP-JUNCTION CHANNELS, TUMOR-NECROSIS-FACTOR, SPINAL-CORD-INJURY, MEDIATED INTERCELLULAR COMMUNICATION, TO-CELL COMMUNICATION, RENIN-PRODUCING CELLS, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, PERIODONTAL-LIGAMENT FIBROBLASTS, BACTERIUM STAPHYLOCOCCUS-AUREUS, MICROVASCULAR ENDOTHELIAL-CELLS

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MLA
Willebrords, Joost, et al. “Connexins and Their Channels in Inflammation.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 51, no. 6, 2016, pp. 413–39.
APA
Willebrords, J., Crespo Yanguas, S., Maes, M., Decrock, E., Wang, N., Leybaert, L., … Vinken, M. (2016). Connexins and their channels in inflammation. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 51(6), 413–439.
Chicago author-date
Willebrords, Joost, Sara Crespo Yanguas, Michael Maes, Elke Decrock, Nan Wang, Luc Leybaert, Brenda R Kwak, Colin R Green, Bruno Cogliati, and Mathieu Vinken. 2016. “Connexins and Their Channels in Inflammation.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 51 (6): 413–39.
Chicago author-date (all authors)
Willebrords, Joost, Sara Crespo Yanguas, Michael Maes, Elke Decrock, Nan Wang, Luc Leybaert, Brenda R Kwak, Colin R Green, Bruno Cogliati, and Mathieu Vinken. 2016. “Connexins and Their Channels in Inflammation.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 51 (6): 413–439.
Vancouver
1.
Willebrords J, Crespo Yanguas S, Maes M, Decrock E, Wang N, Leybaert L, et al. Connexins and their channels in inflammation. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2016;51(6):413–39.
IEEE
[1]
J. Willebrords et al., “Connexins and their channels in inflammation,” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 51, no. 6, pp. 413–439, 2016.
@article{8121355,
  abstract     = {Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration. Despite the wealth of knowledge regarding the involvement of cellular communication in inflammation, studies on the role of connexin-based channels in this process have only begun to emerge in the last few years. In this paper, a state-of-the-art overview of the effects of inflammation on connexin signaling is provided. Vice versa, the involvement of connexins and their channels in inflammation will be discussed by relying on studies that use a variety of experimental tools, such as genetically modified animals, small interfering RNA and connexin-based channel blockers. A better understanding of the importance of connexin signaling in inflammation may open up towards clinical perspectives.},
  author       = {Willebrords, Joost and Crespo Yanguas, Sara and Maes, Michael and Decrock, Elke and Wang, Nan and Leybaert, Luc and Kwak, Brenda R and Green, Colin R and Cogliati, Bruno and Vinken, Mathieu},
  issn         = {1040-9238},
  journal      = {CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY},
  keywords     = {Connexins,gap junctions,hemichannels,inflammation,cytokines,GAP-JUNCTION CHANNELS,TUMOR-NECROSIS-FACTOR,SPINAL-CORD-INJURY,MEDIATED INTERCELLULAR COMMUNICATION,TO-CELL COMMUNICATION,RENIN-PRODUCING CELLS,EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS,PERIODONTAL-LIGAMENT FIBROBLASTS,BACTERIUM STAPHYLOCOCCUS-AUREUS,MICROVASCULAR ENDOTHELIAL-CELLS},
  language     = {eng},
  number       = {6},
  pages        = {413--439},
  title        = {Connexins and their channels in inflammation},
  url          = {http://dx.doi.org/10.1080/10409238.2016.1204980},
  volume       = {51},
  year         = {2016},
}

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