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Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours

Jessica Filtjens (UGent) , Jiri Keirsse, Els Van Ammel (UGent) , Sylvie Taveirne (UGent) , Aline Van Acker (UGent) , Tessa Kerre (UGent) , Tom Taghon (UGent) , Bart Vandekerckhove (UGent) , Jean Plum (UGent) , Jo A Van Ginderachter, et al.
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Abstract
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity. The Ly49 family of NK receptors is composed of several members that recognize major histocompatibility complex class I (MHC-I) or MHC-I-related molecules. Ly49E is a unique inhibitory member, being triggered by the non-MHC-I-related protein urokinase plasminogen activator (uPA) in contrast to the known MHC-I-triggering of the other inhibitory Ly49 receptors. Ly49E also has an uncommon expression pattern on NK cells, including high expression on liver DX5-NK cells. Furthermore, Ly49E is the only Ly49 member expressed by epidermal gamma delta T cells. As gamma delta T cells and/or NK cells have been shown to be involved in the regulation of cutaneous, pulmonary and liver malignancies, and as uPA is involved in tumourigenesis, we investigated the role of the inhibitory Ly49E receptor in the anti-tumour immune response. We demonstrate that, although Ly49E is highly expressed on epidermal gamma delta T cells and liver NK cells, this receptor does not play a major role in the control of skin tumour formation or in lung and liver tumour development.
Keywords
UROKINASE PLASMINOGEN-ACTIVATOR, NATURAL-KILLER-CELLS, DELTA T-CELLS, NK CELLS, NKG2D LIGAND, CANCER IMMUNOSURVEILLANCE, IFN-GAMMA, IN-VITRO, METASTASIS, SYSTEM

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Chicago
Filtjens, Jessica, Jiri Keirsse, Els Van Ammel, Sylvie Taveirne, Aline Van Acker, Tessa Kerre, Tom Taghon, et al. 2016. “Expression of the Inhibitory Ly49E Receptor Is Not Critically Involved in the Immune Response Against Cutaneous, Pulmonary or Liver Tumours.” Scientific Reports 6.
APA
Filtjens, J., Keirsse, J., Van Ammel, E., Taveirne, S., Van Acker, A., Kerre, T., Taghon, T., et al. (2016). Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours. SCIENTIFIC REPORTS, 6.
Vancouver
1.
Filtjens J, Keirsse J, Van Ammel E, Taveirne S, Van Acker A, Kerre T, et al. Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours. SCIENTIFIC REPORTS. 2016;6.
MLA
Filtjens, Jessica et al. “Expression of the Inhibitory Ly49E Receptor Is Not Critically Involved in the Immune Response Against Cutaneous, Pulmonary or Liver Tumours.” SCIENTIFIC REPORTS 6 (2016): n. pag. Print.
@article{8119058,
  abstract     = {Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity. The Ly49 family of NK receptors is composed of several members that recognize major histocompatibility complex class I (MHC-I) or MHC-I-related molecules. Ly49E is a unique inhibitory member, being triggered by the non-MHC-I-related protein urokinase plasminogen activator (uPA) in contrast to the known MHC-I-triggering of the other inhibitory Ly49 receptors. Ly49E also has an uncommon expression pattern on NK cells, including high expression on liver DX5-NK cells. Furthermore, Ly49E is the only Ly49 member expressed by epidermal gamma delta T cells. As gamma delta T cells and/or NK cells have been shown to be involved in the regulation of cutaneous, pulmonary and liver malignancies, and as uPA is involved in tumourigenesis, we investigated the role of the inhibitory Ly49E receptor in the anti-tumour immune response. We demonstrate that, although Ly49E is highly expressed on epidermal gamma delta T cells and liver NK cells, this receptor does not play a major role in the control of skin tumour formation or in lung and liver tumour development.},
  articleno    = {30564},
  author       = {Filtjens, Jessica and Keirsse, Jiri and Van Ammel, Els and Taveirne, Sylvie and Van Acker, Aline and Kerre, Tessa and Taghon, Tom and Vandekerckhove, Bart and Plum, Jean and Van Ginderachter, Jo A and Leclercq, Georges},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {UROKINASE PLASMINOGEN-ACTIVATOR,NATURAL-KILLER-CELLS,DELTA T-CELLS,NK CELLS,NKG2D LIGAND,CANCER IMMUNOSURVEILLANCE,IFN-GAMMA,IN-VITRO,METASTASIS,SYSTEM},
  language     = {eng},
  pages        = {10},
  title        = {Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours},
  url          = {http://dx.doi.org/10.1038/srep30564},
  volume       = {6},
  year         = {2016},
}

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