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Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano

Stijn Mouton UGent, Maxime Willems UGent, Patricia Back UGent, Bart Braeckman UGent and Gaetan Borgonie UGent (2009) FRONTIERS IN ZOOLOGY. 6.
abstract
Free-living flatworms ("Turbellaria") are appropriate model organisms to gain better insight into the role of stem cells in ageing and rejuvenation. Ageing research in flatworms is, however, still scarce. This is partly due to culture difficulties and the lack of a complete set of demographic data, including parameters such as median lifespan and age-specific mortality rate. In this paper, we report on the first flatworm survival analysis. We used the species Macrostomum lignano, which is an emerging model for studying the reciprocal influence between stem cells, ageing and rejuvenation. This species has a median lifespan of 205 +/- 13 days (average +/- standard deviation [SD]) and a 90(th) percentile lifespan of 373 +/- 32 days. The maximum lifespan, however, is more than 745 days, and the average survival curve is characterised by a long tail because a small number of individuals lives twice as long as 90% of the population. Similar to earlier observations in a wide range of animals, in M. lignano the age-specific mortality rate increases exponentially, but levels off at the oldest ages. To compare the senescence of M. lignano with that of other ageing models, we determined the mortality rate doubling time, which is 0.20 +/- 0.02 years. As a result, we can conclude that M. lignano shows gradual senescence at a rate similar to the vertebrate ageing models Rattus norvegicus and Mus musculus. We argue that M. lignano is a suitable model for ageing and rejuvenation research, and especially for the role of stem cells in these processes, due to its accessible stem cell system and regeneration capacity, and the possibility of combining stem cell studies with demographic analyses.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Flatworm, Mortality rate, Lifespan, Senescence, Demography, Macrostomum lignano
journal title
FRONTIERS IN ZOOLOGY
Front. Zool.
volume
6
article_number
15
pages
7 pages
Web of Science type
Article
Web of Science id
000268856400001
ISSN
1742-9994
DOI
10.1186/1742-9994-6-15
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
811626
handle
http://hdl.handle.net/1854/LU-811626
date created
2009-12-15 09:46:38
date last changed
2014-04-23 13:33:31
@article{811626,
  abstract     = {Free-living flatworms ({\textacutedbl}Turbellaria{\textacutedbl}) are appropriate model organisms to gain better insight into the role of stem cells in ageing and rejuvenation. Ageing research in flatworms is, however, still scarce. This is partly due to culture difficulties and the lack of a complete set of demographic data, including parameters such as median lifespan and age-specific mortality rate. In this paper, we report on the first flatworm survival analysis. We used the species Macrostomum lignano, which is an emerging model for studying the reciprocal influence between stem cells, ageing and rejuvenation. This species has a median lifespan of 205 +/- 13 days (average +/- standard deviation [SD]) and a 90(th) percentile lifespan of 373 +/- 32 days. The maximum lifespan, however, is more than 745 days, and the average survival curve is characterised by a long tail because a small number of individuals lives twice as long as 90\% of the population. Similar to earlier observations in a wide range of animals, in M. lignano the age-specific mortality rate increases exponentially, but levels off at the oldest ages. To compare the senescence of M. lignano with that of other ageing models, we determined the mortality rate doubling time, which is 0.20 +/- 0.02 years. As a result, we can conclude that M. lignano shows gradual senescence at a rate similar to the vertebrate ageing models Rattus norvegicus and Mus musculus. We argue that M. lignano is a suitable model for ageing and rejuvenation research, and especially for the role of stem cells in these processes, due to its accessible stem cell system and regeneration capacity, and the possibility of combining stem cell studies with demographic analyses.},
  articleno    = {15},
  author       = {Mouton, Stijn and Willems, Maxime and Back, Patricia and Braeckman, Bart and Borgonie, Gaetan},
  issn         = {1742-9994},
  journal      = {FRONTIERS IN ZOOLOGY},
  keyword      = {Flatworm,Mortality rate,Lifespan,Senescence,Demography,Macrostomum lignano},
  language     = {eng},
  pages        = {7},
  title        = {Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano},
  url          = {http://dx.doi.org/10.1186/1742-9994-6-15},
  volume       = {6},
  year         = {2009},
}

Chicago
Mouton, Stijn, Maxime Willems, Patricia Back, Bart Braeckman, and Gaetan Borgonie. 2009. “Demographic Analysis Reveals Gradual Senescence in the Flatworm Macrostomum Lignano.” Frontiers in Zoology 6.
APA
Mouton, S., Willems, M., Back, P., Braeckman, B., & Borgonie, G. (2009). Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano. FRONTIERS IN ZOOLOGY, 6.
Vancouver
1.
Mouton S, Willems M, Back P, Braeckman B, Borgonie G. Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano. FRONTIERS IN ZOOLOGY. 2009;6.
MLA
Mouton, Stijn, Maxime Willems, Patricia Back, et al. “Demographic Analysis Reveals Gradual Senescence in the Flatworm Macrostomum Lignano.” FRONTIERS IN ZOOLOGY 6 (2009): n. pag. Print.