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Evaluation of feline renal perfusion with contrast-enhanced ultrasonography and scintigraphy

Emmelie Stock (UGent) , Katrien Vanderperren (UGent) , Tim Bosmans (UGent) , André Dobbeleir, Luc Duchateau (UGent) , Myriam Hesta (UGent) , Lien Lybaert (UGent) , Kathelijne Peremans (UGent) , Eva Vandermeulen (UGent) and Jimmy Saunders (UGent)
(2016) PLOS ONE. 11(10).
Author
Organization
Abstract
Contrast-enhanced ultrasound (CEUS) is an emerging technique to evaluate tissue perfusion. Promising results have been obtained in the evaluation of renal perfusion in health and disease, both in human and veterinary medicine. Renal scintigraphy using Tc-99m-Mercaptoacetyltriglycine (MAG(3)) is another non-invasive technique that can be used to evaluate renal perfusion. However, no data are available on the ability of CEUS or Tc-99m-MAG(3) scintigraphy to detect small changes in renal perfusion in cats. Therefore, both techniques were applied in a normal feline population to evaluate detection possibilities of perfusion changes by angiotensin II (AT II). Contrast-enhanced ultrasound using a bolus injection of commercially available contrast agent and renal scintigraphy using Tc-99m-MAG(3) were performed in 11 healthy cats after infusion of 0,9% NaCl (control) and AT II. Angiotensin II induced changes were noticed on several CEUS parameters. Mean peak enhancement, wash-in perfusion index and wash-out rate for the entire kidney decreased significantly after AT II infusion. Moreover, a tendency towards a lower wash-in area-under-the curve was present. Renal scintigraphy could not detect perfusion changes induced by AT II. This study shows that CEUS is able to detect changes in feline renal perfusion induced by AT II infusion.
Keywords
CHRONIC KIDNEY-DISEASE, ANGIOTENSIN-II, BLOOD-FLOW, ULTRASOUND, CATS, DOGS, CIRCULATION, STATES, RAT

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MLA
Stock, Emmelie, Katrien Vanderperren, Tim Bosmans, et al. “Evaluation of Feline Renal Perfusion with Contrast-enhanced Ultrasonography and Scintigraphy.” PLOS ONE 11.10 (2016): n. pag. Print.
APA
Stock, Emmelie, Vanderperren, K., Bosmans, T., Dobbeleir, A., Duchateau, L., Hesta, M., Lybaert, L., et al. (2016). Evaluation of feline renal perfusion with contrast-enhanced ultrasonography and scintigraphy. PLOS ONE, 11(10).
Chicago author-date
Stock, Emmelie, Katrien Vanderperren, Tim Bosmans, André Dobbeleir, Luc Duchateau, Myriam Hesta, Lien Lybaert, Kathelijne Peremans, Eva Vandermeulen, and Jimmy Saunders. 2016. “Evaluation of Feline Renal Perfusion with Contrast-enhanced Ultrasonography and Scintigraphy.” Plos One 11 (10).
Chicago author-date (all authors)
Stock, Emmelie, Katrien Vanderperren, Tim Bosmans, André Dobbeleir, Luc Duchateau, Myriam Hesta, Lien Lybaert, Kathelijne Peremans, Eva Vandermeulen, and Jimmy Saunders. 2016. “Evaluation of Feline Renal Perfusion with Contrast-enhanced Ultrasonography and Scintigraphy.” Plos One 11 (10).
Vancouver
1.
Stock E, Vanderperren K, Bosmans T, Dobbeleir A, Duchateau L, Hesta M, et al. Evaluation of feline renal perfusion with contrast-enhanced ultrasonography and scintigraphy. PLOS ONE. 2016;11(10).
IEEE
[1]
E. Stock et al., “Evaluation of feline renal perfusion with contrast-enhanced ultrasonography and scintigraphy,” PLOS ONE, vol. 11, no. 10, 2016.
@article{8115441,
  abstract     = {Contrast-enhanced ultrasound (CEUS) is an emerging technique to evaluate tissue perfusion. Promising results have been obtained in the evaluation of renal perfusion in health and disease, both in human and veterinary medicine. Renal scintigraphy using Tc-99m-Mercaptoacetyltriglycine (MAG(3)) is another non-invasive technique that can be used to evaluate renal perfusion. However, no data are available on the ability of CEUS or Tc-99m-MAG(3) scintigraphy to detect small changes in renal perfusion in cats. Therefore, both techniques were applied in a normal feline population to evaluate detection possibilities of perfusion changes by angiotensin II (AT II). Contrast-enhanced ultrasound using a bolus injection of commercially available contrast agent and renal scintigraphy using Tc-99m-MAG(3) were performed in 11 healthy cats after infusion of 0,9% NaCl (control) and AT II. Angiotensin II induced changes were noticed on several CEUS parameters. Mean peak enhancement, wash-in perfusion index and wash-out rate for the entire kidney decreased significantly after AT II infusion. Moreover, a tendency towards a lower wash-in area-under-the curve was present. Renal scintigraphy could not detect perfusion changes induced by AT II. This study shows that CEUS is able to detect changes in feline renal perfusion induced by AT II infusion.},
  articleno    = {14},
  author       = {Stock, Emmelie and Vanderperren, Katrien and Bosmans, Tim and Dobbeleir, André and Duchateau, Luc and Hesta, Myriam and Lybaert, Lien and Peremans, Kathelijne and Vandermeulen, Eva and Saunders, Jimmy},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {CHRONIC KIDNEY-DISEASE,ANGIOTENSIN-II,BLOOD-FLOW,ULTRASOUND,CATS,DOGS,CIRCULATION,STATES,RAT},
  language     = {eng},
  number       = {10},
  title        = {Evaluation of feline renal perfusion with contrast-enhanced ultrasonography and scintigraphy},
  url          = {http://dx.doi.org/10.1371/journal.pone.0164488},
  volume       = {11},
  year         = {2016},
}

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