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Molecular imaging of hypoxia with radiolabelled agents

Gilles Mees UGent, Rudi Dierckx UGent, CHRISTEL VANGESTEL UGent and Christophe Van De Wiele UGent (2009) EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 36(10). p.1674-1686
abstract
Tissue hypoxia results from an inadequate supply of oxygen (O-2) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant progression. This has led to the development of assays for the detection of hypoxia in patients in order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments. A variety of invasive and non-invasive approaches have been developed to measure tumour oxygenation including oxygen-sensitive electrodes and hypoxia marker techniques using various labels that can be detected by different methods such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), autoradiography and immunohistochemistry. This review aims to give a detailed overview of non-invasive molecular imaging modalities with radiolabelled PET and SPECT tracers that are available to measure tumour hypoxia.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Eur. J. Nucl. Med. Mol. Imaging
volume
36
issue
10
pages
1674 - 1686
Web of Science type
Review
Web of Science id
000270449000018
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.531 (2009)
JCR rank
7/104 (2009)
JCR quartile
1 (2009)
ISSN
1619-7070
DOI
10.1007/s00259-009-1195-9
language
English
UGent publication?
yes
classification
A1
id
810467
handle
http://hdl.handle.net/1854/LU-810467
date created
2009-12-14 12:39:58
date last changed
2009-12-15 15:33:33
@article{810467,
  abstract     = {Tissue hypoxia results from an inadequate supply of oxygen (O-2) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant progression. This has led to the development of assays for the detection of hypoxia in patients in order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments. A variety of invasive and non-invasive approaches have been developed to measure tumour oxygenation including oxygen-sensitive electrodes and hypoxia marker techniques using various labels that can be detected by different methods such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), autoradiography and immunohistochemistry. This review aims to give a detailed overview of non-invasive molecular imaging modalities with radiolabelled PET and SPECT tracers that are available to measure tumour hypoxia.},
  author       = {Mees, Gilles and Dierckx, Rudi and VANGESTEL, CHRISTEL and Van De Wiele, Christophe},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  language     = {eng},
  number       = {10},
  pages        = {1674--1686},
  title        = {Molecular imaging of hypoxia with radiolabelled agents},
  url          = {http://dx.doi.org/10.1007/s00259-009-1195-9},
  volume       = {36},
  year         = {2009},
}

Chicago
Mees, Gilles, Rudi Dierckx, CHRISTEL VANGESTEL, and Christophe Van De Wiele. 2009. “Molecular Imaging of Hypoxia with Radiolabelled Agents.” European Journal of Nuclear Medicine and Molecular Imaging 36 (10): 1674–1686.
APA
Mees, G., Dierckx, R., VANGESTEL, C., & Van De Wiele, C. (2009). Molecular imaging of hypoxia with radiolabelled agents. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 36(10), 1674–1686.
Vancouver
1.
Mees G, Dierckx R, VANGESTEL C, Van De Wiele C. Molecular imaging of hypoxia with radiolabelled agents. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(10):1674–86.
MLA
Mees, Gilles, Rudi Dierckx, CHRISTEL VANGESTEL, et al. “Molecular Imaging of Hypoxia with Radiolabelled Agents.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 36.10 (2009): 1674–1686. Print.