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Forcing cancer cells to commit suicide

CHRISTEL VANGESTEL UGent, Christophe Van De Wiele UGent, Gilles Mees UGent and Marc Peeters UGent (2009) CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. 24(4). p.395-407
abstract
Apoptosis plays a crucial role in the normal development, homeostasis of multicellular organisms, carcinogenic process, and response of cancer cells to anticancer drugs. It is a genetically strictly regulated process, controlled by the balance between pro-and antiapoptotic proteins. Resistance to standard chemotherapeutics also seems to be an apoptosis-related process due to failure to activate the apoptotic machinery. Hence, the molecular pathways (extrinsic and intrinsic) regulating the apoptotic process are attractive targets for potential therapeutic intervention. The goal of proapoptotic drugs is to selectively induce apoptosis in the tumor cell while leaving healthy cells unharmed. Several proapoptotic receptor agonists have recently been developed, activating selectively the extrinsic pathway, and give promising results. Targets for the intrinsic pathway include the Bcl-2 family proteins, the inhibitor of apoptosis proteins, the p53 pathway, and many others. However, several studies have implicated that using monotherapy will probably not be sufficient to sensitize or induce apoptosis in all tumor cells. Most promising results, in terms of killing the tumor cell, will be achieved by the combination of various therapeutic strategies. In this review, promising apoptosis-inducing anticancer therapies are summarized.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
journal title
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
Cancer Biother. Radiopharm.
volume
24
issue
4
pages
395 - 407
Web of Science type
Review
Web of Science id
000269156300002
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.443 (2009)
JCR rank
61/104 (2009)
JCR quartile
3 (2009)
ISSN
1084-9785
DOI
10.1089/cbr.2008.0598
language
English
UGent publication?
yes
classification
A1
id
810128
handle
http://hdl.handle.net/1854/LU-810128
date created
2009-12-14 11:25:34
date last changed
2009-12-15 15:02:35
@article{810128,
  abstract     = {Apoptosis plays a crucial role in the normal development, homeostasis of multicellular organisms, carcinogenic process, and response of cancer cells to anticancer drugs. It is a genetically strictly regulated process, controlled by the balance between pro-and antiapoptotic proteins. Resistance to standard chemotherapeutics also seems to be an apoptosis-related process due to failure to activate the apoptotic machinery. Hence, the molecular pathways (extrinsic and intrinsic) regulating the apoptotic process are attractive targets for potential therapeutic intervention. The goal of proapoptotic drugs is to selectively induce apoptosis in the tumor cell while leaving healthy cells unharmed. Several proapoptotic receptor agonists have recently been developed, activating selectively the extrinsic pathway, and give promising results. Targets for the intrinsic pathway include the Bcl-2 family proteins, the inhibitor of apoptosis proteins, the p53 pathway, and many others. However, several studies have implicated that using monotherapy will probably not be sufficient to sensitize or induce apoptosis in all tumor cells. Most promising results, in terms of killing the tumor cell, will be achieved by the combination of various therapeutic strategies. In this review, promising apoptosis-inducing anticancer therapies are summarized.},
  author       = {VANGESTEL, CHRISTEL and Van De Wiele, Christophe and Mees, Gilles and Peeters, Marc},
  issn         = {1084-9785},
  journal      = {CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS},
  language     = {eng},
  number       = {4},
  pages        = {395--407},
  title        = {Forcing cancer cells to commit suicide},
  url          = {http://dx.doi.org/10.1089/cbr.2008.0598},
  volume       = {24},
  year         = {2009},
}

Chicago
VANGESTEL, CHRISTEL, Christophe Van De Wiele, Gilles Mees, and Marc Peeters. 2009. “Forcing Cancer Cells to Commit Suicide.” Cancer Biotherapy and Radiopharmaceuticals 24 (4): 395–407.
APA
VANGESTEL, C., Van De Wiele, C., Mees, G., & Peeters, M. (2009). Forcing cancer cells to commit suicide. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 24(4), 395–407.
Vancouver
1.
VANGESTEL C, Van De Wiele C, Mees G, Peeters M. Forcing cancer cells to commit suicide. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. 2009;24(4):395–407.
MLA
VANGESTEL, CHRISTEL, Christophe Van De Wiele, Gilles Mees, et al. “Forcing Cancer Cells to Commit Suicide.” CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 24.4 (2009): 395–407. Print.