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Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis

Gilles Mees UGent, Philippe Fonteyne UGent, Wim Ceelen UGent, Tom Boterberg UGent, Patrick Pauwels UGent, CHRISTEL VANGESTEL UGent, Nancy Van Damme UGent, Marc Peeters UGent, Rudi Dierckx UGent and Christophe Van De Wiele UGent (2009) CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. 24(5). p.565-572
abstract
Erythropoietin (EPO) has been used to correct cancer-related anemia and to improve tumor hypoxia, which both adversely affect the clinical condition of cancer patients and response to radiotherapy. Data available on the effects of EPO treatment in cancer are, however, conflicting. Several clinical studies investigating the influence of EPO treatment have given contradictory results as to whether or not this treatment positively influences survival. In light of these conflicting results, we studied the effects of EPO treatment either alone or in combination with radiotherapy on tumor oxygenation and on the expression pattern of several proteins related to tumor metabolism, survival, and spread in a rat colorectal cancer model. We found a statistically significant upregulation of hexokinase I, N-cadherin, and glucose transporter 3 when EPO treatment was combined with radiotherapy. Because these three proteins have distinct functions in protecting the cell in compromised conditions, these results indicate a detrimental role for the combination of EPO treatment and radiotherapy through the stimulation of tumor-cell metabolism, inhibition of apoptosis, and stimulation of tumor spread and seem to indicate that recombinant human EPO treatment negatively modulates radiotherapy efficacy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
Cancer Biother. Radiopharm.
volume
24
issue
5
pages
565 - 572
Web of Science type
Article
Web of Science id
000271392000007
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.443 (2009)
JCR rank
61/104 (2009)
JCR quartile
3 (2009)
ISSN
1084-9785
DOI
10.1089/cbr.2009.0621
language
English
UGent publication?
yes
classification
A1
id
809759
handle
http://hdl.handle.net/1854/LU-809759
date created
2009-12-14 10:34:38
date last changed
2010-01-21 10:43:31
@article{809759,
  abstract     = {Erythropoietin (EPO) has been used to correct cancer-related anemia and to improve tumor hypoxia, which both adversely affect the clinical condition of cancer patients and response to radiotherapy. Data available on the effects of EPO treatment in cancer are, however, conflicting. Several clinical studies investigating the influence of EPO treatment have given contradictory results as to whether or not this treatment positively influences survival. In light of these conflicting results, we studied the effects of EPO treatment either alone or in combination with radiotherapy on tumor oxygenation and on the expression pattern of several proteins related to tumor metabolism, survival, and spread in a rat colorectal cancer model. We found a statistically significant upregulation of hexokinase I, N-cadherin, and glucose transporter 3 when EPO treatment was combined with radiotherapy. Because these three proteins have distinct functions in protecting the cell in compromised conditions, these results indicate a detrimental role for the combination of EPO treatment and radiotherapy through the stimulation of tumor-cell metabolism, inhibition of apoptosis, and stimulation of tumor spread and seem to indicate that recombinant human EPO treatment negatively modulates radiotherapy efficacy.},
  author       = {Mees, Gilles and Fonteyne, Philippe and Ceelen, Wim and Boterberg, Tom and Pauwels, Patrick and VANGESTEL, CHRISTEL and Van Damme, Nancy and Peeters, Marc and Dierckx, Rudi and Van De Wiele, Christophe},
  issn         = {1084-9785},
  journal      = {CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS},
  language     = {eng},
  number       = {5},
  pages        = {565--572},
  title        = {Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis},
  url          = {http://dx.doi.org/10.1089/cbr.2009.0621},
  volume       = {24},
  year         = {2009},
}

Chicago
Mees, Gilles, Philippe Fonteyne, Wim Ceelen, Tom Boterberg, Patrick Pauwels, CHRISTEL VANGESTEL, Nancy Van Damme, Marc Peeters, Rudi Dierckx, and Christophe Van De Wiele. 2009. “Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis.” Cancer Biotherapy and Radiopharmaceuticals 24 (5): 565–572.
APA
Mees, G., Fonteyne, P., Ceelen, W., Boterberg, T., Pauwels, P., VANGESTEL, C., Van Damme, N., et al. (2009). Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 24(5), 565–572.
Vancouver
1.
Mees G, Fonteyne P, Ceelen W, Boterberg T, Pauwels P, VANGESTEL C, et al. Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. 2009;24(5):565–72.
MLA
Mees, Gilles, Philippe Fonteyne, Wim Ceelen, et al. “Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis.” CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 24.5 (2009): 565–572. Print.