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Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis

Gilles Mees (UGent) , Philippe Fonteyne (UGent) , Wim Ceelen (UGent) , Tom Boterberg (UGent) , Patrick Pauwels (UGent) , CHRISTEL VANGESTEL, Nancy Van Damme (UGent) , Marc Peeters (UGent) , Rudi Dierckx (UGent) and Christophe Van De Wiele (UGent)
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Abstract
Erythropoietin (EPO) has been used to correct cancer-related anemia and to improve tumor hypoxia, which both adversely affect the clinical condition of cancer patients and response to radiotherapy. Data available on the effects of EPO treatment in cancer are, however, conflicting. Several clinical studies investigating the influence of EPO treatment have given contradictory results as to whether or not this treatment positively influences survival. In light of these conflicting results, we studied the effects of EPO treatment either alone or in combination with radiotherapy on tumor oxygenation and on the expression pattern of several proteins related to tumor metabolism, survival, and spread in a rat colorectal cancer model. We found a statistically significant upregulation of hexokinase I, N-cadherin, and glucose transporter 3 when EPO treatment was combined with radiotherapy. Because these three proteins have distinct functions in protecting the cell in compromised conditions, these results indicate a detrimental role for the combination of EPO treatment and radiotherapy through the stimulation of tumor-cell metabolism, inhibition of apoptosis, and stimulation of tumor spread and seem to indicate that recombinant human EPO treatment negatively modulates radiotherapy efficacy.

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MLA
Mees, Gilles et al. “Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis.” CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 24.5 (2009): 565–572. Print.
APA
Mees, G., Fonteyne, P., Ceelen, W., Boterberg, T., Pauwels, P., VANGESTEL, C., Van Damme, N., et al. (2009). Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 24(5), 565–572.
Chicago author-date
Mees, Gilles, Philippe Fonteyne, Wim Ceelen, Tom Boterberg, Patrick Pauwels, CHRISTEL VANGESTEL, Nancy Van Damme, Marc Peeters, Rudi Dierckx, and Christophe Van De Wiele. 2009. “Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis.” Cancer Biotherapy and Radiopharmaceuticals 24 (5): 565–572.
Chicago author-date (all authors)
Mees, Gilles, Philippe Fonteyne, Wim Ceelen, Tom Boterberg, Patrick Pauwels, CHRISTEL VANGESTEL, Nancy Van Damme, Marc Peeters, Rudi Dierckx, and Christophe Van De Wiele. 2009. “Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis.” Cancer Biotherapy and Radiopharmaceuticals 24 (5): 565–572.
Vancouver
1.
Mees G, Fonteyne P, Ceelen W, Boterberg T, Pauwels P, VANGESTEL C, et al. Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. 2009;24(5):565–72.
IEEE
[1]
G. Mees et al., “Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis,” CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, vol. 24, no. 5, pp. 565–572, 2009.
@article{809759,
  abstract     = {Erythropoietin (EPO) has been used to correct cancer-related anemia and to improve tumor hypoxia, which both adversely affect the clinical condition of cancer patients and response to radiotherapy. Data available on the effects of EPO treatment in cancer are, however, conflicting. Several clinical studies investigating the influence of EPO treatment have given contradictory results as to whether or not this treatment positively influences survival. In light of these conflicting results, we studied the effects of EPO treatment either alone or in combination with radiotherapy on tumor oxygenation and on the expression pattern of several proteins related to tumor metabolism, survival, and spread in a rat colorectal cancer model. We found a statistically significant upregulation of hexokinase I, N-cadherin, and glucose transporter 3 when EPO treatment was combined with radiotherapy. Because these three proteins have distinct functions in protecting the cell in compromised conditions, these results indicate a detrimental role for the combination of EPO treatment and radiotherapy through the stimulation of tumor-cell metabolism, inhibition of apoptosis, and stimulation of tumor spread and seem to indicate that recombinant human EPO treatment negatively modulates radiotherapy efficacy.},
  author       = {Mees, Gilles and Fonteyne, Philippe and Ceelen, Wim and Boterberg, Tom and Pauwels, Patrick and VANGESTEL, CHRISTEL and Van Damme, Nancy and Peeters, Marc and Dierckx, Rudi and Van De Wiele, Christophe},
  issn         = {1084-9785},
  journal      = {CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS},
  language     = {eng},
  number       = {5},
  pages        = {565--572},
  title        = {Combined effect of EPO and radiotherapy on the expression of endogenous molecular markers of tumor metabolism and metastasis},
  url          = {http://dx.doi.org/10.1089/cbr.2009.0621},
  volume       = {24},
  year         = {2009},
}

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