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ICDs at higher age and clinical risk factors

(2014) NETHERLANDS HEART JOURNAL. 22(6). p.279-285
Author
Organization
Abstract
Background: The implantable cardioverter defibrillator (ICD) is effective in preventing sudden cardiac death. However, in elderly patients (aged 75 years or older) the role of ICDs is still not well-defined and controversial. Methods: We retrospectively analysed all clinical and survival data of all ICD patients who were >= 75 years at the date of implantation in the Erasmus MC, Rotterdam, the Netherlands and the University Hospital, Basel, Switzerland. Kaplan-Meier survival analysis was performed, and mortality predictors were identified. Mortality of the cohort was compared with a random sample of patients aged 60-70 years originating from the same database and to an age-and sex-matched cohort of Dutch persons. Results: The study cohort consisted of 179 patients aged 75 years or older who were implanted between February 1999 and July 2008. The median follow-up time was 2.0 (IQR 2.8) years. Survival rates after 1, 2 and 3 years were 87, 82, 75 %, respectively. Survival was similar for primary and secondary prevention. Mortality in this study population could be predicted by combining four clinical risk factors: QRS duration >120 ms, NYHA class > II, renal failure and atrial fibrillation (AF). Survival was worse compared with the group of ICD patients aged 60-70 years and to the age-and sex-matched group of elderly persons. However, survival was not significantly worse when comparing elderly ICD patients without additional risk factors to the general population. Conclusions: Elderly patients still have an acceptable survival probability independent of prevention indication, certainly if there are no additional clinical risk factors. The presence or absence of additional clinical risk factors should be taken into account when making the decision for implantation, since they strongly correlate with survival.
Keywords
Survival, Implantable cardioverter defibrillator, Age, Comorbidity, Geriatric cardiology, IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR, T-WAVE ALTERNANS, SIGNAL-AVERAGED ELECTROCARDIOGRAPHY, MYOCARDIAL-INFARCTION, SUDDEN-DEATH, THERAPY, STRATIFICATION, PREVENTION, AMIODARONE, GUIDELINES

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Chicago
Anne, W, DAMJ Theuns, B Schaer, Y Van Belle, T Szili-Torok, T Smith, J Res, and Luc Jordaens. 2014. “ICDs at Higher Age and Clinical Risk Factors.” Netherlands Heart Journal 22 (6): 279–285.
APA
Anne, W., Theuns, D., Schaer, B., Van Belle, Y., Szili-Torok, T., Smith, T., Res, J., et al. (2014). ICDs at higher age and clinical risk factors. NETHERLANDS HEART JOURNAL, 22(6), 279–285.
Vancouver
1.
Anne W, Theuns D, Schaer B, Van Belle Y, Szili-Torok T, Smith T, et al. ICDs at higher age and clinical risk factors. NETHERLANDS HEART JOURNAL. 2014;22(6):279–85.
MLA
Anne, W et al. “ICDs at Higher Age and Clinical Risk Factors.” NETHERLANDS HEART JOURNAL 22.6 (2014): 279–285. Print.
@article{8089093,
  abstract     = {Background: The implantable cardioverter defibrillator (ICD) is effective in preventing sudden cardiac death. However, in elderly patients (aged 75 years or older) the role of ICDs is still not well-defined and controversial. 
Methods: We retrospectively analysed all clinical and survival data of all ICD patients who were >= 75 years at the date of implantation in the Erasmus MC, Rotterdam, the Netherlands and the University Hospital, Basel, Switzerland. Kaplan-Meier survival analysis was performed, and mortality predictors were identified. Mortality of the cohort was compared with a random sample of patients aged 60-70 years originating from the same database and to an age-and sex-matched cohort of Dutch persons. 
Results: The study cohort consisted of 179 patients aged 75 years or older who were implanted between February 1999 and July 2008. The median follow-up time was 2.0 (IQR 2.8) years. Survival rates after 1, 2 and 3 years were 87, 82, 75 %, respectively. Survival was similar for primary and secondary prevention. Mortality in this study population could be predicted by combining four clinical risk factors: QRS duration >120 ms, NYHA class > II, renal failure and atrial fibrillation (AF). Survival was worse compared with the group of ICD patients aged 60-70 years and to the age-and sex-matched group of elderly persons. However, survival was not significantly worse when comparing elderly ICD patients without additional risk factors to the general population. 
Conclusions: Elderly patients still have an acceptable survival probability independent of prevention indication, certainly if there are no additional clinical risk factors. The presence or absence of additional clinical risk factors should be taken into account when making the decision for implantation, since they strongly correlate with survival.},
  author       = {Anne, W and Theuns, DAMJ and Schaer, B and Van Belle, Y and Szili-Torok, T and Smith, T and Res, J and Jordaens, Luc},
  issn         = {1568-5888},
  journal      = {NETHERLANDS HEART JOURNAL},
  keywords     = {Survival,Implantable cardioverter defibrillator,Age,Comorbidity,Geriatric cardiology,IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR,T-WAVE ALTERNANS,SIGNAL-AVERAGED ELECTROCARDIOGRAPHY,MYOCARDIAL-INFARCTION,SUDDEN-DEATH,THERAPY,STRATIFICATION,PREVENTION,AMIODARONE,GUIDELINES},
  language     = {eng},
  number       = {6},
  pages        = {279--285},
  title        = {ICDs at higher age and clinical risk factors},
  url          = {http://dx.doi.org/10.1007/s12471-014-0553-9},
  volume       = {22},
  year         = {2014},
}

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