Advanced search
1 file | 882.61 KB Add to list

Circadian rhythms in water and solute handling in adults with a spinal cord injury

Marie-Astrid Denys (UGent) , Annick Viaene (UGent) , An-Sofie Goessaert (UGent) , Friedl Vanhaverbeke, Piet Hoebeke (UGent) , Ann Raes (UGent) and Karel Everaert (UGent)
(2017) JOURNAL OF UROLOGY. 197(2). p.445-451
Author
Organization
Abstract
Purpose: We evaluated nocturnal urine production and circadian rhythms of renal function (glomerular filtration, and water and solute diuresis) in adults with spinal cord injury compared to controls. Materials and Methods: This prospective observational study was done at Ghent University Hospital, Belgium. Participants were asked to perform a 24-hour urine collection. A blood sample was taken to calculate the diuresis rate and the renal clearance of creatinine, free water, solutes, sodium and urea. Results: A total of 119 patients were divided into 32 with spinal cord injury, and 68 controls with and 19 without nocturnal polyuria. Spinal cord injured patients showed no circadian rhythms in the diuresis rate or in the renal clearance of creatinine, free water, solutes, sodium or urea. Controls without nocturnal polyuria reported a lower nighttime diuresis rate and lower nighttime clearance of creatinine, solutes, sodium and urea compared to daytime levels. Controls with nocturnal polyuria had no circadian rhythms in the diuresis rate or creatinine clearance and a significant increase in nocturnal free water clearance compared to daytime levels. Conclusions: Comparing the mechanisms underlying nocturnal urine production between patients with spinal cord injury and controls revealed important differences. Spinal cord injured patients showed absent circadian rhythms in the renal clearance of creatinine (glomerular filtration), free water (water diuresis) and solutes such as sodium and urea (solute diuresis). Future research must be done to evaluate the role of patient stratification to find the most effective and safe treatment or combination of treatments for spinal cord injured patients with complaints or complications related to nocturnal polyuria.
Keywords
urinary bladder, neurogenic, circadian rhythm, spinal cord injuries, nocturia, polyuria, ANTIDIURETIC-HORMONE LEVELS, NOCTURNAL POLYURIA, BLOOD-PRESSURE, ORTHOSTATIC HYPOTENSION, DIURNAL-VARIATION, HYPERTENSION, DEFINITION, OUTPUT

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 882.61 KB

Citation

Please use this url to cite or link to this publication:

MLA
Denys, Marie-Astrid et al. “Circadian Rhythms in Water and Solute Handling in Adults with a Spinal Cord Injury.” JOURNAL OF UROLOGY 197.2 (2017): 445–451. Print.
APA
Denys, M.-A., Viaene, A., Goessaert, A.-S., Vanhaverbeke, F., Hoebeke, P., Raes, A., & Everaert, K. (2017). Circadian rhythms in water and solute handling in adults with a spinal cord injury. JOURNAL OF UROLOGY, 197(2), 445–451.
Chicago author-date
Denys, Marie-Astrid, Annick Viaene, An-Sofie Goessaert, Friedl Vanhaverbeke, Piet Hoebeke, Ann Raes, and Karel Everaert. 2017. “Circadian Rhythms in Water and Solute Handling in Adults with a Spinal Cord Injury.” Journal of Urology 197 (2): 445–451.
Chicago author-date (all authors)
Denys, Marie-Astrid, Annick Viaene, An-Sofie Goessaert, Friedl Vanhaverbeke, Piet Hoebeke, Ann Raes, and Karel Everaert. 2017. “Circadian Rhythms in Water and Solute Handling in Adults with a Spinal Cord Injury.” Journal of Urology 197 (2): 445–451.
Vancouver
1.
Denys M-A, Viaene A, Goessaert A-S, Vanhaverbeke F, Hoebeke P, Raes A, et al. Circadian rhythms in water and solute handling in adults with a spinal cord injury. JOURNAL OF UROLOGY. 2017;197(2):445–51.
IEEE
[1]
M.-A. Denys et al., “Circadian rhythms in water and solute handling in adults with a spinal cord injury,” JOURNAL OF UROLOGY, vol. 197, no. 2, pp. 445–451, 2017.
@article{8088158,
  abstract     = {Purpose: We evaluated nocturnal urine production and circadian rhythms of renal function (glomerular filtration, and water and solute diuresis) in adults with spinal cord injury compared to controls. 
Materials and Methods: This prospective observational study was done at Ghent University Hospital, Belgium. Participants were asked to perform a 24-hour urine collection. A blood sample was taken to calculate the diuresis rate and the renal clearance of creatinine, free water, solutes, sodium and urea. 
Results: A total of 119 patients were divided into 32 with spinal cord injury, and 68 controls with and 19 without nocturnal polyuria. Spinal cord injured patients showed no circadian rhythms in the diuresis rate or in the renal clearance of creatinine, free water, solutes, sodium or urea. Controls without nocturnal polyuria reported a lower nighttime diuresis rate and lower nighttime clearance of creatinine, solutes, sodium and urea compared to daytime levels. Controls with nocturnal polyuria had no circadian rhythms in the diuresis rate or creatinine clearance and a significant increase in nocturnal free water clearance compared to daytime levels. 
Conclusions: Comparing the mechanisms underlying nocturnal urine production between patients with spinal cord injury and controls revealed important differences. Spinal cord injured patients showed absent circadian rhythms in the renal clearance of creatinine (glomerular filtration), free water (water diuresis) and solutes such as sodium and urea (solute diuresis). Future research must be done to evaluate the role of patient stratification to find the most effective and safe treatment or combination of treatments for spinal cord injured patients with complaints or complications related to nocturnal polyuria.},
  author       = {Denys, Marie-Astrid and Viaene, Annick and Goessaert, An-Sofie and Vanhaverbeke, Friedl and Hoebeke, Piet and Raes, Ann and Everaert, Karel},
  issn         = {0022-5347},
  journal      = {JOURNAL OF UROLOGY},
  keywords     = {urinary bladder,neurogenic,circadian rhythm,spinal cord injuries,nocturia,polyuria,ANTIDIURETIC-HORMONE LEVELS,NOCTURNAL POLYURIA,BLOOD-PRESSURE,ORTHOSTATIC HYPOTENSION,DIURNAL-VARIATION,HYPERTENSION,DEFINITION,OUTPUT},
  language     = {eng},
  number       = {2},
  pages        = {445--451},
  title        = {Circadian rhythms in water and solute handling in adults with a spinal cord injury},
  url          = {http://dx.doi.org/10.1016/j.juro.2016.08.001},
  volume       = {197},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: