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The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis

Sofie Depluverez (UGent) , Simon Devos (UGent) and Bart Devreese (UGent)
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Abstract
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene. A defect in the CFTR ion channel causes a dramatic change in the composition of the airway surface fluid, leading to a highly viscous mucus layer. In healthy individuals, the majority of bacteria trapped in the mucus layer are removed and destroyed by mucociliary clearance. However, in the lungs of patients with CF, the mucociliary clearance is impaired due to dehydration of the airway surface fluid. As a consequence, patients with CF are highly susceptible to chronic or intermittent pulmonary infections, often causing extensive lung inflammation and damage, accompanied by a decreased life expectancy. This mini review will focus on the different secretion mechanisms used by the major bacterial CF pathogens to release virulence factors, their role in resistance and discusses the potential for therapeutically targeting secretion systems.
Keywords
infection, cystic fibrosis, pathogenesis, antimicrobial resistance, protein biosynthesis, Gram-negative bacteria, OUTER-MEMBRANE VESICLES, PSEUDOMONAS-AERUGINOSA, III SECRETION, BURKHOLDERIA-CEPACIA, STENOTROPHOMONAS-MALTOPHILIA, IV SECRETION, HAEMOPHILUS-INFLUENZAE, PROTEIN SECRETION, BIOFILM FORMATION, BETA-LACTAMASE

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Please use this url to cite or link to this publication:

Chicago
Depluverez, Sofie, Simon Devos, and Bart Devreese. 2016. “The Role of Bacterial Secretion Systems in the Virulence of Gram-negative Airway Pathogens Associated with Cystic Fibrosis.” Frontiers in Microbiology 7.
APA
Depluverez, S., Devos, S., & Devreese, B. (2016). The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis. FRONTIERS IN MICROBIOLOGY, 7.
Vancouver
1.
Depluverez S, Devos S, Devreese B. The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis. FRONTIERS IN MICROBIOLOGY. 2016;7.
MLA
Depluverez, Sofie, Simon Devos, and Bart Devreese. “The Role of Bacterial Secretion Systems in the Virulence of Gram-negative Airway Pathogens Associated with Cystic Fibrosis.” FRONTIERS IN MICROBIOLOGY 7 (2016): n. pag. Print.
@article{8086764,
  abstract     = {Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene. A defect in the CFTR ion channel causes a dramatic change in the composition of the airway surface fluid, leading to a highly viscous mucus layer. In healthy individuals, the majority of bacteria trapped in the mucus layer are removed and destroyed by mucociliary clearance. However, in the lungs of patients with CF, the mucociliary clearance is impaired due to dehydration of the airway surface fluid. As a consequence, patients with CF are highly susceptible to chronic or intermittent pulmonary infections, often causing extensive lung inflammation and damage, accompanied by a decreased life expectancy. This mini review will focus on the different secretion mechanisms used by the major bacterial CF pathogens to release virulence factors, their role in resistance and discusses the potential for therapeutically targeting secretion systems.},
  articleno    = {1336},
  author       = {Depluverez, Sofie and Devos, Simon and Devreese, Bart},
  issn         = {1664-302X},
  journal      = {FRONTIERS IN MICROBIOLOGY},
  keyword      = {infection,cystic fibrosis,pathogenesis,antimicrobial resistance,protein biosynthesis,Gram-negative bacteria,OUTER-MEMBRANE VESICLES,PSEUDOMONAS-AERUGINOSA,III SECRETION,BURKHOLDERIA-CEPACIA,STENOTROPHOMONAS-MALTOPHILIA,IV SECRETION,HAEMOPHILUS-INFLUENZAE,PROTEIN SECRETION,BIOFILM FORMATION,BETA-LACTAMASE},
  language     = {eng},
  pages        = {8},
  title        = {The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis},
  url          = {http://dx.doi.org/10.3389/fmicb.2016.01336},
  volume       = {7},
  year         = {2016},
}

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