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Transcranial direct current stimulation over the right frontal inferior cortex decreases neural activity needed to achieve inhibition : a double-blind ERP study in a male population

Salvatore Campanella, Elisa Schroder, Aurore Monnart, Marie-Anne Vanderhasselt UGent, Romain Duprat, Mark Rabijns, Charles Kornreich, Paul Verbanck and Chris Baeken UGent (2017) CLINICAL EEG AND NEUROSCIENCE. 48(3). p.176-188
abstract
Inhibitory control refers to the ability to inhibit an action once it has been initiated. Impaired inhibitory control plays a key role in triggering relapse in some pathological states, such as addictions. Therefore, a major challenge of current research is to establish new methods to strengthen inhibitory control in these "high-risk" populations. In this attempt, the right inferior frontal cortex (rIFC), a neural correlate crucial for inhibitory control, was modulated using transcranial direct current stimulation (tDCS). Healthy participants (n = 31) were presented with a "Go/No-go" task, a well-known paradigm to measure inhibitory control. During this task, an event-related potential (ERP) recording (T1; 32 channels) was performed. One subgroup (n = 15) was randomly assigned to a condition with tDCS (anodal electrode was placed on the rIFC and the cathodal on the neck); and the other group (n = 16) to a condition with sham (placebo) tDCS. After one 20-minute neuromodulation session, all participants were confronted again with the same ERP Go/ No-go task (T2). To ensure that potential tDCS effects were specific to inhibition, ERPs to a face-detection task were also recorded at T1 and T2 in both subgroups. The rate of commission errors on the Go/ No-go task was similar between T1 and T2 in both neuromodulation groups. However, the amplitude of the P3d component, indexing the inhibition function per se, was reduced at T2 as compared with T1. This effect was specific for participants in the tDCS (and not sham) condition for correctly inhibited trials. No difference in the P3 component was observable between both subgroups at T1 and T2 for the face detection task. Overall, the present data indicate that boosting the rIFC specifically enhances inhibitory skills by decreasing the neural activity needed to correctly inhibit a response.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
right inferior frontal gyrus, inhibition, Evoked potential, tDCS, amplitude modulation, EVENT-RELATED POTENTIALS, DORSOLATERAL PREFRONTAL CORTEX, DETOXIFIED ALCOHOLIC PATIENTS, GO NOGO TASKS, RESPONSE-INHIBITION, COGNITIVE CONTROL, WORKING-MEMORY, GO/NOGO TASK, GREATER SENSITIVITY, MAJOR DEPRESSION
journal title
CLINICAL EEG AND NEUROSCIENCE
Clin. EEG Neurosci.
volume
48
issue
3
pages
176 - 188
Web of Science type
Article
Web of Science id
000403282400003
ISSN
1550-0594
DOI
10.1177/1550059416645977
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8085742
handle
http://hdl.handle.net/1854/LU-8085742
date created
2016-09-23 10:40:36
date last changed
2017-07-06 10:25:37
@article{8085742,
  abstract     = {Inhibitory control refers to the ability to inhibit an action once it has been initiated. Impaired inhibitory control plays a key role in triggering relapse in some pathological states, such as addictions. Therefore, a major challenge of current research is to establish new methods to strengthen inhibitory control in these {\textacutedbl}high-risk{\textacutedbl} populations. In this attempt, the right inferior frontal cortex (rIFC), a neural correlate crucial for inhibitory control, was modulated using transcranial direct current stimulation (tDCS). Healthy participants (n = 31) were presented with a {\textacutedbl}Go/No-go{\textacutedbl} task, a well-known paradigm to measure inhibitory control. During this task, an event-related potential (ERP) recording (T1; 32 channels) was performed. One subgroup (n = 15) was randomly assigned to a condition with tDCS (anodal electrode was placed on the rIFC and the cathodal on the neck); and the other group (n = 16) to a condition with sham (placebo) tDCS. After one 20-minute neuromodulation session, all participants were confronted again with the same ERP Go/ No-go task (T2). To ensure that potential tDCS effects were specific to inhibition, ERPs to a face-detection task were also recorded at T1 and T2 in both subgroups. The rate of commission errors on the Go/ No-go task was similar between T1 and T2 in both neuromodulation groups. However, the amplitude of the P3d component, indexing the inhibition function per se, was reduced at T2 as compared with T1. This effect was specific for participants in the tDCS (and not sham) condition for correctly inhibited trials. No difference in the P3 component was observable between both subgroups at T1 and T2 for the face detection task. Overall, the present data indicate that boosting the rIFC specifically enhances inhibitory skills by decreasing the neural activity needed to correctly inhibit a response.},
  author       = {Campanella, Salvatore and Schroder, Elisa and Monnart, Aurore and Vanderhasselt, Marie-Anne and Duprat, Romain and Rabijns, Mark and Kornreich, Charles and Verbanck, Paul and Baeken, Chris},
  issn         = {1550-0594},
  journal      = {CLINICAL EEG AND NEUROSCIENCE},
  keyword      = {right inferior frontal gyrus,inhibition,Evoked potential,tDCS,amplitude modulation,EVENT-RELATED POTENTIALS,DORSOLATERAL PREFRONTAL CORTEX,DETOXIFIED ALCOHOLIC PATIENTS,GO NOGO TASKS,RESPONSE-INHIBITION,COGNITIVE CONTROL,WORKING-MEMORY,GO/NOGO TASK,GREATER SENSITIVITY,MAJOR DEPRESSION},
  language     = {eng},
  number       = {3},
  pages        = {176--188},
  title        = {Transcranial direct current stimulation over the right frontal inferior cortex decreases neural activity needed to achieve inhibition : a double-blind ERP study in a male population},
  url          = {http://dx.doi.org/10.1177/1550059416645977},
  volume       = {48},
  year         = {2017},
}

Chicago
Campanella, Salvatore, Elisa Schroder, Aurore Monnart, Marie-Anne Vanderhasselt, Romain Duprat, Mark Rabijns, Charles Kornreich, Paul Verbanck, and Chris Baeken. 2017. “Transcranial Direct Current Stimulation over the Right Frontal Inferior Cortex Decreases Neural Activity Needed to Achieve Inhibition : a Double-blind ERP Study in a Male Population.” Clinical Eeg and Neuroscience 48 (3): 176–188.
APA
Campanella, Salvatore, Schroder, E., Monnart, A., Vanderhasselt, M.-A., Duprat, R., Rabijns, M., Kornreich, C., et al. (2017). Transcranial direct current stimulation over the right frontal inferior cortex decreases neural activity needed to achieve inhibition : a double-blind ERP study in a male population. CLINICAL EEG AND NEUROSCIENCE, 48(3), 176–188.
Vancouver
1.
Campanella S, Schroder E, Monnart A, Vanderhasselt M-A, Duprat R, Rabijns M, et al. Transcranial direct current stimulation over the right frontal inferior cortex decreases neural activity needed to achieve inhibition : a double-blind ERP study in a male population. CLINICAL EEG AND NEUROSCIENCE. 2017;48(3):176–88.
MLA
Campanella, Salvatore, Elisa Schroder, Aurore Monnart, et al. “Transcranial Direct Current Stimulation over the Right Frontal Inferior Cortex Decreases Neural Activity Needed to Achieve Inhibition : a Double-blind ERP Study in a Male Population.” CLINICAL EEG AND NEUROSCIENCE 48.3 (2017): 176–188. Print.