Advanced search
1 file | 409.74 KB Add to list

Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens

Sandra De Boever (UGent) , Siska Croubels (UGent) , Evelyne Meyer (UGent) , Stanislas Sys (UGent) , Rudi Beyaert (UGent) , Richard Ducatelle (UGent) and Patrick De Backer (UGent)
(2009) AVIAN PATHOLOGY. 38(5). p.403-411
Author
Organization
Abstract
Intravenous administration of lipopolysaccharide (LPS) from Escherichia coli O127:B8 at a dose of 1,500,000 u/kg body weight evoked a hypothermic response followed by a fever phase in 5-week-old broiler chickens. The hypothermic phase coincided with a severe decrease in blood pressure. We assume that this decrease in blood pressure is, at least partly, responsible for the hypothermic phase of the body temperature curve. LPS administration also caused a decrease in circulating white blood cells. The heterophils were predominantly sequestered in the lungs. In LPS-treated chickens, far more apoptotic leukocytes were present in the circulation, compared with control chickens. The molecular players responsible for the LPS-induced inflammatory response could be TL1A, IL-1b and IL-6, since a slight increase in their mRNA levels in white blood cells was already seen 1 h after LPS administration. In accordance with these observations, the levels of secreted IL-6 were maximal 3 h after LPS administration. These parameters characterize this LPSinduced inflammation model in broiler chickens.
Keywords
POLYMORPHONUCLEAR LEUKOCYTES, HYPOTHERMIA, GENE-EXPRESSION, GALLUS-DOMESTICUS, LUNG INJURY, IN-VIVO, ESCHERICHIA-COLI ENDOTOXIN, PULMONARY VASCULAR SEQUESTRATION, INDUCED SHOCK, NITRIC-OXIDE SYNTHASE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 409.74 KB

Citation

Please use this url to cite or link to this publication:

MLA
De Boever, Sandra et al. “Characterization of an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens.” AVIAN PATHOLOGY 38.5 (2009): 403–411. Print.
APA
De Boever, S., Croubels, S., Meyer, E., Sys, S., Beyaert, R., Ducatelle, R., & De Backer, P. (2009). Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens. AVIAN PATHOLOGY, 38(5), 403–411.
Chicago author-date
De Boever, Sandra, Siska Croubels, Evelyne Meyer, Stanislas Sys, Rudi Beyaert, Richard Ducatelle, and Patrick De Backer. 2009. “Characterization of an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens.” Avian Pathology 38 (5): 403–411.
Chicago author-date (all authors)
De Boever, Sandra, Siska Croubels, Evelyne Meyer, Stanislas Sys, Rudi Beyaert, Richard Ducatelle, and Patrick De Backer. 2009. “Characterization of an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens.” Avian Pathology 38 (5): 403–411.
Vancouver
1.
De Boever S, Croubels S, Meyer E, Sys S, Beyaert R, Ducatelle R, et al. Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens. AVIAN PATHOLOGY. ABINGDON: TAYLOR & FRANCIS LTD; 2009;38(5):403–11.
IEEE
[1]
S. De Boever et al., “Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens,” AVIAN PATHOLOGY, vol. 38, no. 5, pp. 403–411, 2009.
@article{808270,
  abstract     = {Intravenous administration of lipopolysaccharide (LPS) from Escherichia coli O127:B8 at a dose of 1,500,000 u/kg body weight evoked a hypothermic response followed by a fever phase in 5-week-old broiler chickens. The hypothermic phase coincided with a severe decrease in blood pressure. We assume that this decrease in blood pressure is, at least partly, responsible for the hypothermic phase of the body temperature
curve. LPS administration also caused a decrease in circulating white blood cells. The heterophils were
predominantly sequestered in the lungs. In LPS-treated chickens, far more apoptotic leukocytes were present
in the circulation, compared with control chickens. The molecular players responsible for the LPS-induced
inflammatory response could be TL1A, IL-1b and IL-6, since a slight increase in their mRNA levels in white blood cells was already seen 1 h after LPS administration. In accordance with these observations, the levels of secreted IL-6 were maximal 3 h after LPS administration. These parameters characterize this LPSinduced inflammation model in broiler chickens.},
  author       = {De Boever, Sandra and Croubels, Siska and Meyer, Evelyne and Sys, Stanislas and Beyaert, Rudi and Ducatelle, Richard and De Backer, Patrick},
  issn         = {0307-9457},
  journal      = {AVIAN PATHOLOGY},
  keywords     = {POLYMORPHONUCLEAR LEUKOCYTES,HYPOTHERMIA,GENE-EXPRESSION,GALLUS-DOMESTICUS,LUNG INJURY,IN-VIVO,ESCHERICHIA-COLI ENDOTOXIN,PULMONARY VASCULAR SEQUESTRATION,INDUCED SHOCK,NITRIC-OXIDE SYNTHASE},
  language     = {eng},
  number       = {5},
  pages        = {403--411},
  publisher    = {TAYLOR & FRANCIS LTD},
  title        = {Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens},
  url          = {http://dx.doi.org/10.1080/03079450903190871},
  volume       = {38},
  year         = {2009},
}

Altmetric
View in Altmetric
Web of Science
Times cited: