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An investigation of the effect of gastrointestinal microbial activity on oral arsenic bioavailability

Brian D Laird, Kyle J James, Tom Van de Wiele UGent, Matt Dodd, Stan W Casteel, Mark Wickstrom and Steven D Siciliano (2013) JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING. 48(6). p.612-619
abstract
In vitro gastrointestinal (GI) microbial activity in the colon compartment facilitates the arsenic release from soils into simulated GI fluids. Consequentially, it is possible that in vitro models that neglect to include microbial activity underestimate arsenic bioaccessibility when calculating oral exposure. However, the toxicological relevance of increased arsenic release due to microbial activity is contingent upon the subsequent absorption of arsenic solubilized in the GI lumen. The objectives of this research are to: (1) assess whether microbes in the in vitro small intestine affect arsenic solubilization from soils, (2) determine whether differences in the GI microbial community result in differences in the oral bioavailability of soil-borne arsenic. In vitro GI microbial activity in the distal small intestine increased arsenic release from soils; however, these effects were unlikely to be relevant since they were transient and demonstrated small effect sizes. In vivo arsenic absorption for juvenile swine was unaffected by antibiotic treatment. Therefore, it appears that microbial effects on arsenic release do not result in increased arsenic bioavailability. However, it remains to be seen whether the results for the limited set of soils described herein can be extrapolated to arsenic contaminated sites in general.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
arsenic, Absolute bioavailability, soil contamination, ingestion exposure, colon microorganisms, IN-VITRO DIGESTION, CONTAMINATED SOILS, RISK-ASSESSMENT, GUT MICROBIOTA, BIOACCESSIBILITY, METABOLISM, SIMULATOR, ECOSYSTEM, MERCURY, RATS
journal title
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
J. Environ. Sci. Health Part A-Toxic/Hazard. Subst. Environ. Eng.
volume
48
issue
6
pages
612 - 619
Web of Science type
Article
Web of Science id
000315343800004
JCR category
ENGINEERING, ENVIRONMENTAL
JCR impact factor
1.135 (2013)
JCR rank
31/46 (2013)
JCR quartile
3 (2013)
ISSN
1093-4529
DOI
10.1080/10934529.2013.731357
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8080228
handle
http://hdl.handle.net/1854/LU-8080228
date created
2016-09-19 14:31:02
date last changed
2016-12-19 15:45:45
@article{8080228,
  abstract     = {In vitro gastrointestinal (GI) microbial activity in the colon compartment facilitates the arsenic release from soils into simulated GI fluids. Consequentially, it is possible that in vitro models that neglect to include microbial activity underestimate arsenic bioaccessibility when calculating oral exposure. However, the toxicological relevance of increased arsenic release due to microbial activity is contingent upon the subsequent absorption of arsenic solubilized in the GI lumen. The objectives of this research are to: (1) assess whether microbes in the in vitro small intestine affect arsenic solubilization from soils, (2) determine whether differences in the GI microbial community result in differences in the oral bioavailability of soil-borne arsenic. In vitro GI microbial activity in the distal small intestine increased arsenic release from soils; however, these effects were unlikely to be relevant since they were transient and demonstrated small effect sizes. In vivo arsenic absorption for juvenile swine was unaffected by antibiotic treatment. Therefore, it appears that microbial effects on arsenic release do not result in increased arsenic bioavailability. However, it remains to be seen whether the results for the limited set of soils described herein can be extrapolated to arsenic contaminated sites in general.},
  author       = {Laird, Brian D and James, Kyle J and Van de Wiele, Tom and Dodd, Matt and Casteel, Stan W and Wickstrom, Mark and Siciliano, Steven D},
  issn         = {1093-4529},
  journal      = {JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES \& ENVIRONMENTAL ENGINEERING},
  keyword      = {arsenic,Absolute bioavailability,soil contamination,ingestion exposure,colon microorganisms,IN-VITRO DIGESTION,CONTAMINATED SOILS,RISK-ASSESSMENT,GUT MICROBIOTA,BIOACCESSIBILITY,METABOLISM,SIMULATOR,ECOSYSTEM,MERCURY,RATS},
  language     = {eng},
  number       = {6},
  pages        = {612--619},
  title        = {An investigation of the effect of gastrointestinal microbial activity on oral arsenic bioavailability},
  url          = {http://dx.doi.org/10.1080/10934529.2013.731357},
  volume       = {48},
  year         = {2013},
}

Chicago
Laird, Brian D, Kyle J James, Tom Van de Wiele, Matt Dodd, Stan W Casteel, Mark Wickstrom, and Steven D Siciliano. 2013. “An Investigation of the Effect of Gastrointestinal Microbial Activity on Oral Arsenic Bioavailability.” Journal of Environmental Science and Health Part A-toxic/hazardous Substances & Environmental Engineering 48 (6): 612–619.
APA
Laird, B. D., James, K. J., Van de Wiele, T., Dodd, M., Casteel, S. W., Wickstrom, M., & Siciliano, S. D. (2013). An investigation of the effect of gastrointestinal microbial activity on oral arsenic bioavailability. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, 48(6), 612–619.
Vancouver
1.
Laird BD, James KJ, Van de Wiele T, Dodd M, Casteel SW, Wickstrom M, et al. An investigation of the effect of gastrointestinal microbial activity on oral arsenic bioavailability. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING. 2013;48(6):612–9.
MLA
Laird, Brian D, Kyle J James, Tom Van de Wiele, et al. “An Investigation of the Effect of Gastrointestinal Microbial Activity on Oral Arsenic Bioavailability.” JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING 48.6 (2013): 612–619. Print.