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The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure

(2016) JOURNAL OF VIRUS ERADICATION. 2(3). p.175-176
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Abstract
The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome. This integrated proviral DNA can remain replication silent, but a small part of it is fully competent to restart viral replication when treatment is interrupted. Hence, this replication-competent provirus is the cause of viral rebound and is called the viral reservoir. The exact site of proviral integration within the host` s cellular chromosome may affect the transcriptional activity of HIV. Thanks to recent technological advances, HIV-1 integration site analysis has been used to assess HIV-1 reservoirs in HIV-infected individuals. Analysis of HIV-1 integration sites in infected individuals undergoing suppressive ART led to identification of expanded clonal cell populations, indicating that clonal proliferation of the proviral reservoir may contribute to the long-term persistence of viral reservoirs. Here we describe the findings of several clinical studies, where a comprehensive HIV-1 integration site analysis was performed.
Keywords
integration site, HIV-1, HIV-1 persistence KeyWords Plus:ACTIVE ANTIRETROVIRAL THERAPY, INFECTION, SELECTION, CELLS, PROLIFERATION, REPLICATION, MAINTAINS, RESERVOIR

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Citation

Please use this url to cite or link to this publication:

MLA
Kiselinova, Maja, Ward De Spiegelaere, and Linos Vandekerckhove. “The Use of HIV-1 Integration Site Analysis Information in Clinical Studies Aiming at HIV Cure.” JOURNAL OF VIRUS ERADICATION 2.3 (2016): 175–176. Print.
APA
Kiselinova, M., De Spiegelaere, W., & Vandekerckhove, L. (2016). The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure. JOURNAL OF VIRUS ERADICATION, 2(3), 175–176.
Chicago author-date
Kiselinova, Maja, Ward De Spiegelaere, and Linos Vandekerckhove. 2016. “The Use of HIV-1 Integration Site Analysis Information in Clinical Studies Aiming at HIV Cure.” Journal of Virus Eradication 2 (3): 175–176.
Chicago author-date (all authors)
Kiselinova, Maja, Ward De Spiegelaere, and Linos Vandekerckhove. 2016. “The Use of HIV-1 Integration Site Analysis Information in Clinical Studies Aiming at HIV Cure.” Journal of Virus Eradication 2 (3): 175–176.
Vancouver
1.
Kiselinova M, De Spiegelaere W, Vandekerckhove L. The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure. JOURNAL OF VIRUS ERADICATION. 2016;2(3):175–6.
IEEE
[1]
M. Kiselinova, W. De Spiegelaere, and L. Vandekerckhove, “The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure,” JOURNAL OF VIRUS ERADICATION, vol. 2, no. 3, pp. 175–176, 2016.
@article{8075059,
  abstract     = {The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome. This integrated proviral DNA can remain replication silent, but a small part of it is fully competent to restart viral replication when treatment is interrupted. Hence, this replication-competent provirus is the cause of viral rebound and is called the viral reservoir. The exact site of proviral integration within the host` s cellular chromosome may affect the transcriptional activity of HIV. Thanks to recent technological advances, HIV-1 integration site analysis has been used to assess HIV-1 reservoirs in HIV-infected individuals. Analysis of HIV-1 integration sites in infected individuals undergoing suppressive ART led to identification of expanded clonal cell populations, indicating that clonal proliferation of the proviral reservoir may contribute to the long-term persistence of viral reservoirs. Here we describe the findings of several clinical studies, where a comprehensive HIV-1 integration site analysis was performed.},
  author       = {Kiselinova, Maja and De Spiegelaere, Ward and Vandekerckhove, Linos},
  issn         = {2055-6640},
  journal      = {JOURNAL OF VIRUS ERADICATION},
  keywords     = {integration site,HIV-1,HIV-1 persistence   KeyWords Plus:ACTIVE ANTIRETROVIRAL THERAPY,INFECTION,SELECTION,CELLS,PROLIFERATION,REPLICATION,MAINTAINS,RESERVOIR},
  language     = {eng},
  number       = {3},
  pages        = {175--176},
  title        = {The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure},
  url          = {http://viruseradication.com/journal-details/The_use_of_HIV-1_integration_site_analysis_information_in_clinical_studies_aiming_at_HIV_cure/},
  volume       = {2},
  year         = {2016},
}