Advanced search
1 file | 3.90 MB

Bacterial secretion systems with an emphasis on the Chlamydial type III secretion system

Author
Organization
Abstract
Numerous bacterial proteins exert their function outside the prokaryotic cell. To this end, both Gram-negative and Gram-positive bacteria have evolved specialized mechanisms to transport their proteins to the bacterial supernatant or host cell cytoplasm, so called secretion systems. These different strategies will be briefly discussed, followed by an in depth description of the Type III secretion system, an efficient molecular syringe assisting Gram-negative bacteria in entrance, growth and survival in eukaryotic host cells. Topics addressed include classification and role of multiple Type III secretion systems, the mechanism of protein translocation into the host cell as well as substrate recognition and chaperoning. Chlamydiales have also been found to encode a Type III secretion system and associated effector proteins. In contrast to the genetic organization in other bacteria, the encoding genes are scattered throughout the genome. To date, no structural information is available on the chlamydial Type III secretion system. We therefore propose a model of the chlamydial Type III secretion system and summarize current knowledge on the role of Type III secretion in the different stages of the chlamydial developmental cycle.
Keywords
GENOME SEQUENCE, YOP SECRETION, HOST-CELL, ESCHERICHIA-COLI, INCLUSION MEMBRANE-PROTEIN, TWIN-ARGININE TRANSLOCASE, MIP-LIKE PROTEIN, OUTER-MEMBRANE, YERSINIA-ENTEROCOLITICA, GRAM-NEGATIVE BACTERIA

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 3.90 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Beeckman, Delphine Sylvie Anne, and Daisy Vanrompay. 2010. “Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System.” Current Issues in Molecular Biology 12 (1): 17–41.
APA
Beeckman, D. S. A., & Vanrompay, D. (2010). Bacterial secretion systems with an emphasis on the Chlamydial type III secretion system. CURRENT ISSUES IN MOLECULAR BIOLOGY, 12(1), 17–41.
Vancouver
1.
Beeckman DSA, Vanrompay D. Bacterial secretion systems with an emphasis on the Chlamydial type III secretion system. CURRENT ISSUES IN MOLECULAR BIOLOGY. 2010;12(1):17–41.
MLA
Beeckman, Delphine Sylvie Anne, and Daisy Vanrompay. “Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System.” CURRENT ISSUES IN MOLECULAR BIOLOGY 12.1 (2010): 17–41. Print.
@article{806787,
  abstract     = {Numerous bacterial proteins exert their function outside the prokaryotic cell. To this end, both Gram-negative and Gram-positive bacteria have evolved specialized mechanisms to transport their proteins to the bacterial supernatant or host cell cytoplasm, so called secretion systems. These different strategies will be briefly discussed, followed by an in depth description of the Type III secretion system, an efficient molecular syringe assisting Gram-negative bacteria in entrance, growth and survival in eukaryotic host cells. Topics addressed include classification and role of multiple Type III secretion systems, the mechanism of protein translocation into the host cell as well as substrate recognition and chaperoning.
Chlamydiales have also been found to encode a Type III secretion system and associated effector proteins. In contrast to the genetic organization in other bacteria, the encoding genes are scattered throughout the genome. To date, no structural information is available on the chlamydial Type III secretion system. We therefore propose a model of the chlamydial Type III secretion system and summarize current knowledge on the role of Type III secretion in the different stages of the chlamydial developmental cycle.},
  author       = {Beeckman, Delphine Sylvie Anne and Vanrompay, Daisy},
  issn         = {1467-3037},
  journal      = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
  keywords     = {GENOME SEQUENCE,YOP SECRETION,HOST-CELL,ESCHERICHIA-COLI,INCLUSION MEMBRANE-PROTEIN,TWIN-ARGININE TRANSLOCASE,MIP-LIKE PROTEIN,OUTER-MEMBRANE,YERSINIA-ENTEROCOLITICA,GRAM-NEGATIVE BACTERIA},
  language     = {eng},
  number       = {1},
  pages        = {17--41},
  title        = {Bacterial secretion systems with an emphasis on the Chlamydial type III secretion system},
  volume       = {12},
  year         = {2010},
}

Web of Science
Times cited: