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Comparison of metal free polymer-dye conjugation strategies in protic solvents

(2016) POLYMER CHEMISTRY. 7(17). p.3046-3055
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Abstract
Polymer-dye conjugations are one of the common examples for polymer modifications. They represent a crucial step for imaging in optical microscopy or for tracing and marking macromolecules. In this work, we present a comparison between quick and efficient conjugation reactions that do not rely on the use of a metal catalyst, which could contaminate the resulting polymer and hinder its use for subsequent biological applications. Moreover, since the conjugation strategy needs to be compatible with the solvent system used to solubilise the polymer, we focussed our attention on assessing these conjugation approaches for their feasibility with a sample polymer that is only soluble in protic solvents. The methods studied include the ring-strain promoted azide-alkyne click reaction, thiol/maleimide conjugation as well as the 1,2,4-triazoline-3,5-dione (TAD) with a diene moiety, one of the latest click chemistries available.
Keywords
PH, FUNCTIONALIZATION, DELIVERY, CLICK CHEMISTRY, ENCAPSULATION, EFFICIENT, VESICLES, AFFINITY, SYSTEMS, CELLS

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Chicago
Gaitzsch, Jens, Maarten Delahaye, Alessandro Poma, Filip Du Prez, and Giuseppe Battaglia. 2016. “Comparison of Metal Free Polymer-dye Conjugation Strategies in Protic Solvents.” Polymer Chemistry 7 (17): 3046–3055.
APA
Gaitzsch, J., Delahaye, M., Poma, A., Du Prez, F., & Battaglia, G. (2016). Comparison of metal free polymer-dye conjugation strategies in protic solvents. POLYMER CHEMISTRY, 7(17), 3046–3055.
Vancouver
1.
Gaitzsch J, Delahaye M, Poma A, Du Prez F, Battaglia G. Comparison of metal free polymer-dye conjugation strategies in protic solvents. POLYMER CHEMISTRY. 2016;7(17):3046–55.
MLA
Gaitzsch, Jens et al. “Comparison of Metal Free Polymer-dye Conjugation Strategies in Protic Solvents.” POLYMER CHEMISTRY 7.17 (2016): 3046–3055. Print.
@article{8067781,
  abstract     = {Polymer-dye conjugations are one of the common examples for polymer modifications. They represent a crucial step for imaging in optical microscopy or for tracing and marking macromolecules. In this work, we present a comparison between quick and efficient conjugation reactions that do not rely on the use of a metal catalyst, which could contaminate the resulting polymer and hinder its use for subsequent biological applications. Moreover, since the conjugation strategy needs to be compatible with the solvent system used to solubilise the polymer, we focussed our attention on assessing these conjugation approaches for their feasibility with a sample polymer that is only soluble in protic solvents. The methods studied include the ring-strain promoted azide-alkyne click reaction, thiol/maleimide conjugation as well as the 1,2,4-triazoline-3,5-dione (TAD) with a diene moiety, one of the latest click chemistries available.},
  author       = {Gaitzsch, Jens and Delahaye, Maarten and Poma, Alessandro and Du Prez, Filip and Battaglia, Giuseppe},
  issn         = {1759-9954},
  journal      = {POLYMER CHEMISTRY},
  keywords     = {PH,FUNCTIONALIZATION,DELIVERY,CLICK CHEMISTRY,ENCAPSULATION,EFFICIENT,VESICLES,AFFINITY,SYSTEMS,CELLS},
  language     = {eng},
  number       = {17},
  pages        = {3046--3055},
  title        = {Comparison of metal free polymer-dye conjugation strategies in protic solvents},
  url          = {http://dx.doi.org/10.1039/c6py00518g},
  volume       = {7},
  year         = {2016},
}

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