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Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation and cytokine production

(2009) Inflammation research. 58(12). p.845-854
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Abstract
Abstract: Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential influence and the mechanisms leading to differences in strains. We applied a mouse model of allergic asthma to BALB/c and C57BL/6 mice. BALB/c mice displayed greater levels of airway reactivity to methacholine than C57BL/6 mice. Moreover, BALB/c mice exhibited higher numbers of mast cells in lung tissue when compared to C57BL/6. On the contrary, eosinophil and neutrophil counts in bronchoalveolar lavage fluid (BALF) as well as peribronchial eosinophilia were greater in C57BL/6. IL (Interleukin)-4, IL-5, IL-13, and CCL11 levels measured in whole-lung extracts were higher in BALB/c, while, in sharp contrast, CCL11 and CCL5 levels were higher in BALF of C57BL/6 mice. We observed phenotypic differences between C57BL/6 and BALB/c mice in an asthma model with different distributions of pro-inflammatory cytokines and inflammatory cells.
Keywords
Animal models, asthma, cytokines, inflammation, chemokines

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Citation

Please use this url to cite or link to this publication:

Chicago
Gueders, Maud, Genevieve Paulissen, Celine Crahay, Florence Quesada-Calvo, Jonathan Hacha, Chris Van Hove, Kurt Tournoy, et al. 2009. “Mouse Models of Asthma: a Comparison Between C57BL/6 and BALB/c Strains Regarding Bronchial Responsiveness, Inflammation and Cytokine Production.” Inflammation Research 58 (12): 845–854.
APA
Gueders, M., Paulissen, G., Crahay, C., Quesada-Calvo, F., Hacha, J., Van Hove, C., Tournoy, K., et al. (2009). Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation and cytokine production. Inflammation research, 58(12), 845–854.
Vancouver
1.
Gueders M, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, et al. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation and cytokine production. Inflammation research. Basel, Switzerland: Birkhauser Verlag AG; 2009;58(12):845–54.
MLA
Gueders, Maud et al. “Mouse Models of Asthma: a Comparison Between C57BL/6 and BALB/c Strains Regarding Bronchial Responsiveness, Inflammation and Cytokine Production.” Inflammation research 58.12 (2009): 845–854. Print.
@article{806648,
  abstract     = {Abstract: Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential influence and the mechanisms leading to differences in strains.
We applied a mouse model of allergic asthma to BALB/c and C57BL/6 mice.

BALB/c mice displayed greater levels of airway reactivity to methacholine than C57BL/6 mice. Moreover, BALB/c mice exhibited higher numbers of mast cells in lung tissue when compared to C57BL/6. On the contrary, eosinophil and neutrophil counts in bronchoalveolar lavage fluid (BALF) as well as peribronchial eosinophilia were greater in C57BL/6. IL (Interleukin)-4, IL-5, IL-13, and CCL11 levels measured in whole-lung extracts were higher in BALB/c, while, in sharp contrast, CCL11 and CCL5 levels were higher in BALF of C57BL/6 mice.

We observed phenotypic differences between C57BL/6 and BALB/c mice in an asthma model with different distributions of pro-inflammatory cytokines and inflammatory cells.},
  author       = {Gueders, Maud and Paulissen, Genevieve and Crahay, Celine and Quesada-Calvo, Florence and Hacha, Jonathan and Van Hove, Chris and Tournoy, Kurt and Louis, Renaud and Foidart, Jean-Michel and Noel, Agnes and Cataldo, Didier},
  issn         = {1023-3830},
  journal      = {Inflammation research},
  language     = {eng},
  number       = {12},
  pages        = {845--854},
  publisher    = {Birkhauser Verlag AG},
  title        = {Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation and cytokine production},
  url          = {http://dx.doi.org/10.1007/s00011-009-0054-2},
  volume       = {58},
  year         = {2009},
}

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