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Cu isotopic signature in blood serum of liver transplant patients: a follow-up study

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Abstract
End-stage liver disease (ESLD) is life-threatening and liver transplantation (LTx) is the definitive treatment with good outcomes. Given the essential role of hepatocytes in Cu homeostasis, the potential of the serum Cu isotopic composition for monitoring a patient's condition post-LTx was evaluated. For this purpose, high-precision Cu isotopic analysis of blood serum of ESLD patients pre- and post-LTx was accomplished via multi-collector ICP-mass spectrometry (MC-ICP-MS). The Cu isotopic composition of the ESLD patients was fractionated in favour of the lighter isotope (by about -0.50 parts per thousand). Post-LTx, a generalized normalization of the Cu isotopic composition was observed for the patients with normal liver function, while it remained light when this condition was not reached. A strong decrease in the delta Cu-65 value a longer term post-LTx seems to indicate the recurrence of liver failure or cancer. The observed trend in favour of the heavier Cu isotopic composition post-LTx seems to be related with the restored biosynthetic capacity of the liver, the restored hepatic metabolism and/or the restored biliary secretion pathways. Thus, Cu isotopic analysis could be a valuable tool for the follow-up of liver transplant patients and for establishing the potential recurrence of liver failure.
Keywords
ICP-MASS SPECTROMETRY, WILSONS-DISEASE, PRIMARY BILIARY-CIRRHOSIS, COPPER-METABOLISM, METALLOTHIONEIN CONCENTRATION, MOLECULAR-MECHANISMS, ZINC, DISORDERS, DIAGNOSIS, MANGANESE

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MLA
Lauwens, Sara, et al. “Cu Isotopic Signature in Blood Serum of Liver Transplant Patients: A Follow-up Study.” SCIENTIFIC REPORTS, vol. 6, 2016.
APA
Lauwens, S., Costas Rodriguez, M., Van Vlierberghe, H., & Vanhaecke, F. (2016). Cu isotopic signature in blood serum of liver transplant patients: a follow-up study. SCIENTIFIC REPORTS, 6.
Chicago author-date
Lauwens, Sara, Marta Costas Rodriguez, Hans Van Vlierberghe, and Frank Vanhaecke. 2016. “Cu Isotopic Signature in Blood Serum of Liver Transplant Patients: A Follow-up Study.” SCIENTIFIC REPORTS 6.
Chicago author-date (all authors)
Lauwens, Sara, Marta Costas Rodriguez, Hans Van Vlierberghe, and Frank Vanhaecke. 2016. “Cu Isotopic Signature in Blood Serum of Liver Transplant Patients: A Follow-up Study.” SCIENTIFIC REPORTS 6.
Vancouver
1.
Lauwens S, Costas Rodriguez M, Van Vlierberghe H, Vanhaecke F. Cu isotopic signature in blood serum of liver transplant patients: a follow-up study. SCIENTIFIC REPORTS. 2016;6.
IEEE
[1]
S. Lauwens, M. Costas Rodriguez, H. Van Vlierberghe, and F. Vanhaecke, “Cu isotopic signature in blood serum of liver transplant patients: a follow-up study,” SCIENTIFIC REPORTS, vol. 6, 2016.
@article{8055712,
  abstract     = {End-stage liver disease (ESLD) is life-threatening and liver transplantation (LTx) is the definitive treatment with good outcomes. Given the essential role of hepatocytes in Cu homeostasis, the potential of the serum Cu isotopic composition for monitoring a patient's condition post-LTx was evaluated. For this purpose, high-precision Cu isotopic analysis of blood serum of ESLD patients pre- and post-LTx was accomplished via multi-collector ICP-mass spectrometry (MC-ICP-MS). The Cu isotopic composition of the ESLD patients was fractionated in favour of the lighter isotope (by about -0.50 parts per thousand). Post-LTx, a generalized normalization of the Cu isotopic composition was observed for the patients with normal liver function, while it remained light when this condition was not reached. A strong decrease in the delta Cu-65 value a longer term post-LTx seems to indicate the recurrence of liver failure or cancer. The observed trend in favour of the heavier Cu isotopic composition post-LTx seems to be related with the restored biosynthetic capacity of the liver, the restored hepatic metabolism and/or the restored biliary secretion pathways. Thus, Cu isotopic analysis could be a valuable tool for the follow-up of liver transplant patients and for establishing the potential recurrence of liver failure.},
  articleno    = {30683},
  author       = {Lauwens, Sara and Costas Rodriguez, Marta and Van Vlierberghe, Hans and Vanhaecke, Frank},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {ICP-MASS SPECTROMETRY,WILSONS-DISEASE,PRIMARY BILIARY-CIRRHOSIS,COPPER-METABOLISM,METALLOTHIONEIN CONCENTRATION,MOLECULAR-MECHANISMS,ZINC,DISORDERS,DIAGNOSIS,MANGANESE},
  language     = {eng},
  pages        = {9},
  title        = {Cu isotopic signature in blood serum of liver transplant patients: a follow-up study},
  url          = {http://dx.doi.org/10.1038/srep30683},
  volume       = {6},
  year         = {2016},
}

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