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A single step process for the synthesis of antigen laden thermosensitive microparticles

Bruno De Geest UGent, Stefaan De Koker UGent, Yves Gonnissen UGent, Liesbeth De Cock UGent, Johan Grooten UGent, Jean Paul Remon UGent and Chris Vervaet UGent (2010) SOFT MATTER. 6(2). p.305-310
abstract
Recent insights in vaccine delivery point out a distinct benefit for antigen to be delivered in a microparticulate form to professional antigen presenting cells. Encapsulation technology to produce antigen laden microparticles often requires complex handlings involving the use of organic solvents, chemical reactivity and/or high shear forces. These issues impair the practical and economical feasibility of such delivery systems. In this paper, we introduce a novel concept for the encapsulation of antigen within microparticles, making use of the lower critical solution temperature (LCST) behavior of a thermosensitive carrier polymer. Particle fabrication and characterization is demonstrated as well as their uptake by dendritic cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
STIMULI-RESPONSIVE POLYMER, IN-VIVO, POLYELECTROLYTE MICROCAPSULES, FILMS
journal title
SOFT MATTER
Soft Matter
volume
6
issue
2
pages
305 - 310
Web of Science type
Article
Web of Science id
000273576800015
JCR category
POLYMER SCIENCE
JCR impact factor
4.457 (2010)
JCR rank
6/78 (2010)
JCR quartile
1 (2010)
ISSN
1744-683X
DOI
10.1039/b912422e
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
805307
handle
http://hdl.handle.net/1854/LU-805307
date created
2009-12-09 13:08:38
date last changed
2012-06-28 12:30:46
@article{805307,
  abstract     = {Recent insights in vaccine delivery point out a distinct benefit for antigen to be delivered in a microparticulate form to professional antigen presenting cells. Encapsulation technology to produce antigen laden microparticles often requires complex handlings involving the use of organic solvents, chemical reactivity and/or high shear forces. These issues impair the practical and economical feasibility of such delivery systems. In this paper, we introduce a novel concept for the encapsulation of antigen within microparticles, making use of the lower critical solution temperature (LCST) behavior of a thermosensitive carrier polymer. Particle fabrication and characterization is demonstrated as well as their uptake by dendritic cells.},
  author       = {De Geest, Bruno and De Koker, Stefaan and Gonnissen, Yves and De Cock, Liesbeth and Grooten, Johan and Remon, Jean Paul and Vervaet, Chris},
  issn         = {1744-683X},
  journal      = {SOFT MATTER},
  keyword      = {STIMULI-RESPONSIVE POLYMER,IN-VIVO,POLYELECTROLYTE MICROCAPSULES,FILMS},
  language     = {eng},
  number       = {2},
  pages        = {305--310},
  title        = {A single step process for the synthesis of antigen laden thermosensitive microparticles},
  url          = {http://dx.doi.org/10.1039/b912422e},
  volume       = {6},
  year         = {2010},
}

Chicago
De Geest, Bruno, Stefaan De Koker, Yves Gonnissen, Liesbeth De Cock, Johan Grooten, Jean Paul Remon, and Chris Vervaet. 2010. “A Single Step Process for the Synthesis of Antigen Laden Thermosensitive Microparticles.” Soft Matter 6 (2): 305–310.
APA
De Geest, B., De Koker, S., Gonnissen, Y., De Cock, L., Grooten, J., Remon, J. P., & Vervaet, C. (2010). A single step process for the synthesis of antigen laden thermosensitive microparticles. SOFT MATTER, 6(2), 305–310.
Vancouver
1.
De Geest B, De Koker S, Gonnissen Y, De Cock L, Grooten J, Remon JP, et al. A single step process for the synthesis of antigen laden thermosensitive microparticles. SOFT MATTER. 2010;6(2):305–10.
MLA
De Geest, Bruno, Stefaan De Koker, Yves Gonnissen, et al. “A Single Step Process for the Synthesis of Antigen Laden Thermosensitive Microparticles.” SOFT MATTER 6.2 (2010): 305–310. Print.