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The effect of hydroxyethyl starch 6% 130/0.4 compared with gelatin on microvascular reactivity

(2016) ANAESTHESIA. 71(7). p.798-805
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Abstract
We compared the effects on microvascular reactivity of hydroxyethylstarch (Volulyte((R))) and gelatin (Geloplasma((R))) during acute haemodilution. The hypothesis was that Volulyte would provide better microvascular reactivity than Geloplasma. Forty patients undergoing elective cardiac surgery were randomly assigned to receive either Volulyte or Geloplasma as the exclusive priming solution of the cardiopulmonary bypass. To evaluate microvascular reactivity, postocclusive reactive hyperaemia was examined before and after cardiopulmonary bypass. Microvascular reactivity assessments included the rate of the occlusion and reperfusion slopes and reperfusion times. After cardiopulmonary bypass, increases in reperfusion time were significantly smaller in the Volulyte group (3 (-27 to 9 [-35 to 33]%) vs 29 (-17 to 76 [-34 to 137]%) in the Geloplasma group, p = 0.02 between groups). Rate of reperfusion increased in the Volulyte group (26 (-17 to 43 [-59 to 357])%), whereas it decreased in the Geloplasma group (-22 (-47 to 16 [-84 to 113])%), p = 0.02 between groups. The shorter reperfusion times and increased reperfusion rate suggest that Volulyte maintains better microvascular reactivity than Geloplasma.
Keywords
crystalloid vs colloid treatment, O-2 delivery to tissues: factors impacting, cardiopulmonary bypass management, NEAR-INFRARED SPECTROSCOPY, ACUTE NORMOVOLEMIC HEMODILUTION, MUSCLE-TISSUE OXYGENATION, VASCULAR OCCLUSION TEST, BLOOD-VISCOSITY, INTENSIVE-CARE, PERFUSION, SURGERY, HES, MICROCIRCULATION

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Chicago
Moerman, Anneliese, CATHERINE VAN EECKHOUT, K Vanderstraeten, Filip De Somer, Yves Van Belleghem, and Stefan De Hert. 2016. “The Effect of Hydroxyethyl Starch 6% 130/0.4 Compared with Gelatin on Microvascular Reactivity.” Anaesthesia 71 (7): 798–805.
APA
Moerman, Anneliese, VAN EECKHOUT, C., Vanderstraeten, K., De Somer, F., Van Belleghem, Y., & De Hert, S. (2016). The effect of hydroxyethyl starch 6% 130/0.4 compared with gelatin on microvascular reactivity. ANAESTHESIA, 71(7), 798–805.
Vancouver
1.
Moerman A, VAN EECKHOUT C, Vanderstraeten K, De Somer F, Van Belleghem Y, De Hert S. The effect of hydroxyethyl starch 6% 130/0.4 compared with gelatin on microvascular reactivity. ANAESTHESIA. 2016;71(7):798–805.
MLA
Moerman, Anneliese, CATHERINE VAN EECKHOUT, K Vanderstraeten, et al. “The Effect of Hydroxyethyl Starch 6% 130/0.4 Compared with Gelatin on Microvascular Reactivity.” ANAESTHESIA 71.7 (2016): 798–805. Print.
@article{8052807,
  abstract     = {We compared the effects on microvascular reactivity of hydroxyethylstarch (Volulyte((R))) and gelatin (Geloplasma((R))) during acute haemodilution. The hypothesis was that Volulyte would provide better microvascular reactivity than Geloplasma. Forty patients undergoing elective cardiac surgery were randomly assigned to receive either Volulyte or Geloplasma as the exclusive priming solution of the cardiopulmonary bypass. To evaluate microvascular reactivity, postocclusive reactive hyperaemia was examined before and after cardiopulmonary bypass. Microvascular reactivity assessments included the rate of the occlusion and reperfusion slopes and reperfusion times. After cardiopulmonary bypass, increases in reperfusion time were significantly smaller in the Volulyte group (3 (-27 to 9 [-35 to 33]\%) vs 29 (-17 to 76 [-34 to 137]\%) in the Geloplasma group, p = 0.02 between groups). Rate of reperfusion increased in the Volulyte group (26 (-17 to 43 [-59 to 357])\%), whereas it decreased in the Geloplasma group (-22 (-47 to 16 [-84 to 113])\%), p = 0.02 between groups. The shorter reperfusion times and increased reperfusion rate suggest that Volulyte maintains better microvascular reactivity than Geloplasma.},
  author       = {Moerman, Anneliese and VAN EECKHOUT, CATHERINE and Vanderstraeten, K and De Somer, Filip and Van Belleghem, Yves and De Hert, Stefan},
  issn         = {0003-2409},
  journal      = {ANAESTHESIA},
  keyword      = {crystalloid vs colloid treatment,O-2 delivery to tissues: factors impacting,cardiopulmonary bypass management,NEAR-INFRARED SPECTROSCOPY,ACUTE NORMOVOLEMIC HEMODILUTION,MUSCLE-TISSUE OXYGENATION,VASCULAR OCCLUSION TEST,BLOOD-VISCOSITY,INTENSIVE-CARE,PERFUSION,SURGERY,HES,MICROCIRCULATION},
  language     = {eng},
  number       = {7},
  pages        = {798--805},
  title        = {The effect of hydroxyethyl starch 6\% 130/0.4 compared with gelatin on microvascular reactivity},
  url          = {http://dx.doi.org/10.1111/anae.13388},
  volume       = {71},
  year         = {2016},
}

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