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Risk of cross-contamination due to the use of antimicrobial medicated feed throughout the trail of feed from the feed mill to the farm

Maria-Eleni Filippitzi UGent, Steven Sarrazin UGent, Hein Imberechts, Annemieke Smet and Jeroen Dewulf UGent (2016) FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT. 33(4). p.644-655
abstract
The cross-contamination of non-medicated feed with residues of antimicrobials causes an animal and public health concern associated with the potential for the selection and dissemination of resistance in commensal bacteria and potentially zoonotic bacteria. To identify the extent of this situation, we built a risk model that provides a way to estimate the percentage of cross-contaminated feed in total and at the different levels at which cross-contamination may occur (i.e. the feed mill, the transport truck, the farm), for different levels of antimicrobial medicated feed produced in a country per year. The model, estimated that when antimicrobial medicated feed represents a hypothetical x(i) = 2% of the total feed produced in a country per year, then 5.5% (95% CI = 3.4%; 11.4%) of the total feed produced in a year could be cross-contaminated with different levels of antimicrobials due to practices related to medicated feed. In detail, 1.80% (95% CI = 0.2%; 7.7%) of the total feed produced in such a country would be cross-contaminated due to antimicrobial carryover occurring at the feed mill level, 1.83% (95% CI = 1.3%; 2.0%) at the transport truck level and 1.84% (95% CI = 1.2%; 2.0%) at the farm level. The model also demonstrated that even in cases where antimicrobial medicated feed would be produced in end-of-line mixers or a fine dosing system on trucks, the risk of cross-contamination would not be negligible; the percentage of cross-contaminated feed produced in a country (where x(i) = 2%) per year would be 3.7% (95% CI = 2.9%; 4.0%) and 2.4% (95% CI = 1.6%; 2.7%), respectively. It is hard to reduce the risk to zero as it is the result of factors occurring at different levels. Thus, the use of antimicrobial medicated feed should be avoided as much as possible to reduce selection pressure.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Medicated feed, cross-contamination, antimicrobials, residues, risk assessment, PRODUCTS, FOOD, RESIDUES
journal title
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
Food Addit. Contam. Part A-Chem.
volume
33
issue
4
pages
644 - 655
Web of Science type
Article
Web of Science id
000374594400008
JCR category
FOOD SCIENCE & TECHNOLOGY
JCR impact factor
2.047 (2016)
JCR rank
40/129 (2016)
JCR quartile
2 (2016)
ISSN
1944-0049
DOI
10.1080/19440049.2016.1160442
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8048449
handle
http://hdl.handle.net/1854/LU-8048449
date created
2016-08-12 11:24:52
date last changed
2016-12-19 15:39:04
@article{8048449,
  abstract     = {The cross-contamination of non-medicated feed with residues of antimicrobials causes an animal and public health concern associated with the potential for the selection and dissemination of resistance in commensal bacteria and potentially zoonotic bacteria. To identify the extent of this situation, we built a risk model that provides a way to estimate the percentage of cross-contaminated feed in total and at the different levels at which cross-contamination may occur (i.e. the feed mill, the transport truck, the farm), for different levels of antimicrobial medicated feed produced in a country per year. The model, estimated that when antimicrobial medicated feed represents a hypothetical x(i) = 2\% of the total feed produced in a country per year, then 5.5\% (95\% CI = 3.4\%; 11.4\%) of the total feed produced in a year could be cross-contaminated with different levels of antimicrobials due to practices related to medicated feed. In detail, 1.80\% (95\% CI = 0.2\%; 7.7\%) of the total feed produced in such a country would be cross-contaminated due to antimicrobial carryover occurring at the feed mill level, 1.83\% (95\% CI = 1.3\%; 2.0\%) at the transport truck level and 1.84\% (95\% CI = 1.2\%; 2.0\%) at the farm level. The model also demonstrated that even in cases where antimicrobial medicated feed would be produced in end-of-line mixers or a fine dosing system on trucks, the risk of cross-contamination would not be negligible; the percentage of cross-contaminated feed produced in a country (where x(i) = 2\%) per year would be 3.7\% (95\% CI = 2.9\%; 4.0\%) and 2.4\% (95\% CI = 1.6\%; 2.7\%), respectively. It is hard to reduce the risk to zero as it is the result of factors occurring at different levels. Thus, the use of antimicrobial medicated feed should be avoided as much as possible to reduce selection pressure.},
  author       = {Filippitzi, Maria-Eleni and Sarrazin, Steven and Imberechts, Hein and Smet, Annemieke and Dewulf, Jeroen},
  issn         = {1944-0049},
  journal      = {FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE \& RISK ASSESSMENT},
  keyword      = {Medicated feed,cross-contamination,antimicrobials,residues,risk assessment,PRODUCTS,FOOD,RESIDUES},
  language     = {eng},
  number       = {4},
  pages        = {644--655},
  title        = {Risk of cross-contamination due to the use of antimicrobial medicated feed throughout the trail of feed from the feed mill to the farm},
  url          = {http://dx.doi.org/10.1080/19440049.2016.1160442},
  volume       = {33},
  year         = {2016},
}

Chicago
Filippitzi, Marilena, Steven Sarrazin, Hein Imberechts, Annemieke Smet, and Jeroen Dewulf. 2016. “Risk of Cross-contamination Due to the Use of Antimicrobial Medicated Feed Throughout the Trail of Feed from the Feed Mill to the Farm.” Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment 33 (4): 644–655.
APA
Filippitzi, M., Sarrazin, S., Imberechts, H., Smet, A., & Dewulf, J. (2016). Risk of cross-contamination due to the use of antimicrobial medicated feed throughout the trail of feed from the feed mill to the farm. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 33(4), 644–655.
Vancouver
1.
Filippitzi M, Sarrazin S, Imberechts H, Smet A, Dewulf J. Risk of cross-contamination due to the use of antimicrobial medicated feed throughout the trail of feed from the feed mill to the farm. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT. 2016;33(4):644–55.
MLA
Filippitzi, Marilena, Steven Sarrazin, Hein Imberechts, et al. “Risk of Cross-contamination Due to the Use of Antimicrobial Medicated Feed Throughout the Trail of Feed from the Feed Mill to the Farm.” FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT 33.4 (2016): 644–655. Print.