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Ageing with elegans: a research proposal to map healthspan pathways

Walter Luyten, Peter Antal, Bart Braeckman (UGent) , Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, et al.
(2016) BIOGERONTOLOGY. 17(4). p.771-782
Author
Organization
Abstract
Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority ; it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme , which has launched several research and innovation actions (RIA), like "Understanding health, ageing and disease: determinants, risk factors and pathways" in the work programme on "Personalising healthcare". Here we present our research proposal entitled "ageing with elegans" (AwE), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism.
Keywords
Longevity Nutraceuticals, Healthspan, Medicinal plants, Natural products, Caenorhabditis elegans, LIFE-SPAN EXTENSION, CAENORHABDITIS-ELEGANS, C.-ELEGANS, LONGEVITY, INTERVIEW, GENETICS, DISEASE, FRAILTY, SYSTEM, GENES

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Citation

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MLA
Luyten, Walter, et al. “Ageing with Elegans: A Research Proposal to Map Healthspan Pathways.” BIOGERONTOLOGY, vol. 17, no. 4, 2016, pp. 771–82, doi:10.1007/s10522-016-9644-x.
APA
Luyten, W., Antal, P., Braeckman, B., Bundy, J., Cirulli, F., Fang-Yen, C., … Rattan, S. I. (2016). Ageing with elegans: a research proposal to map healthspan pathways. BIOGERONTOLOGY, 17(4), 771–782. https://doi.org/10.1007/s10522-016-9644-x
Chicago author-date
Luyten, Walter, Peter Antal, Bart Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, et al. 2016. “Ageing with Elegans: A Research Proposal to Map Healthspan Pathways.” BIOGERONTOLOGY 17 (4): 771–82. https://doi.org/10.1007/s10522-016-9644-x.
Chicago author-date (all authors)
Luyten, Walter, Peter Antal, Bart Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, and Suresh IS Rattan. 2016. “Ageing with Elegans: A Research Proposal to Map Healthspan Pathways.” BIOGERONTOLOGY 17 (4): 771–782. doi:10.1007/s10522-016-9644-x.
Vancouver
1.
Luyten W, Antal P, Braeckman B, Bundy J, Cirulli F, Fang-Yen C, et al. Ageing with elegans: a research proposal to map healthspan pathways. BIOGERONTOLOGY. 2016;17(4):771–82.
IEEE
[1]
W. Luyten et al., “Ageing with elegans: a research proposal to map healthspan pathways,” BIOGERONTOLOGY, vol. 17, no. 4, pp. 771–782, 2016.
@article{8048093,
  abstract     = {{Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority ; it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme , which has launched several research and innovation actions (RIA), like "Understanding health, ageing and disease: determinants, risk factors and pathways" in the work programme on "Personalising healthcare". Here we present our research proposal entitled "ageing with elegans" (AwE), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism.}},
  author       = {{Luyten, Walter and Antal, Peter and Braeckman, Bart and Bundy, Jake and Cirulli, Francesca and Fang-Yen, Christopher and Fuellen, Georg and Leroi, Armand and Liu, Qingfei and Martorell, Patricia and Metspalu, Andres and Perola, Markus and Ristow, Michael and Saul, Nadine and Schoofs, Liliane and Siems, Karsten and Temmerman, Liesbet and Smets, Tina and Wolk, Alicja and Rattan, Suresh IS}},
  issn         = {{1389-5729}},
  journal      = {{BIOGERONTOLOGY}},
  keywords     = {{Longevity Nutraceuticals,Healthspan,Medicinal plants,Natural products,Caenorhabditis elegans,LIFE-SPAN EXTENSION,CAENORHABDITIS-ELEGANS,C.-ELEGANS,LONGEVITY,INTERVIEW,GENETICS,DISEASE,FRAILTY,SYSTEM,GENES}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{771--782}},
  title        = {{Ageing with elegans: a research proposal to map healthspan pathways}},
  url          = {{http://doi.org/10.1007/s10522-016-9644-x}},
  volume       = {{17}},
  year         = {{2016}},
}
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