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Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie

Renée Houben, Gunther Antonissen UGent, Siska Croubels UGent, Patrick De Backer UGent and Mathias Devreese UGent (2016) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 85(3). p.124-132
abstract
The pharmacokinetic processes of drugs, i.e. absorption, distribution, metabolization and elimination, differ between birds and mammals. For instance, the clearance and volume of the distribution of aminoglycosides are lower in birds than in mammals. These pharmacokinetic differences are caused by differences in anatomy, biochemistry and physiology between birds and mammals. The species differences in pharmacokinetics and differences in the observed and predicted pharmacokinetic parameters of some drugs in birds after extrapolation from mammals (e.g. clearance of enrofloxacin, salicylic acid, meloxicam and flunixin), show that pharmacokinetic data on mammals can hardly be extrapolated to birds as such. Furthermore, differences in pharmacokinetic behavior between bird species exist as well. Therefore, the selection of an appropriate posology for birds has to be based on pharmacokinetic data of that specific bird species. In absence of these data, dose selection might be done using allometric scaling. The pharmacokinetic data are scaled in correlation to the body weight of a different bird species. In case these data are also not available, dose selection using allometric scaling with pharmacokinetic data from mammals should preferably only be done for drugs with a low toxicity.
Please use this url to cite or link to this publication:
author
organization
alternative title
Pharmacokinetics of drugs in avian species and the applications and limitations of dose extrapolation
year
type
journalArticle (original)
publication status
published
subject
keyword
PREDICTION, CLEARANCE, CONJUGATION, BENZOIC-ACID, SCAVENGING BIRDS, ALLOMETRIC ANALYSIS, FLUNIXIN MEGLUMINE, SINGLE, KIDNEY, PHARMACODYNAMICS
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneesk. Tijdschr.
volume
85
issue
3
pages
124 - 132
Web of Science type
Article
Web of Science id
000378665200002
JCR category
VETERINARY SCIENCES
JCR impact factor
0.288 (2016)
JCR rank
113/136 (2016)
JCR quartile
4 (2016)
ISSN
0303-9021
language
Dutch
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8046718
handle
http://hdl.handle.net/1854/LU-8046718
alternative location
http://vdt.ugent.be/sites/default/files/art2inDutch.pdf
date created
2016-08-09 15:31:10
date last changed
2016-12-19 15:43:38
@article{8046718,
  abstract     = {The pharmacokinetic processes of drugs, i.e. absorption, distribution, metabolization and elimination, differ between birds and mammals. For instance, the clearance and volume of the distribution of aminoglycosides are lower in birds than in mammals. These pharmacokinetic differences are caused by differences in anatomy, biochemistry and physiology between birds and mammals. The species differences in pharmacokinetics and differences in the observed and predicted pharmacokinetic parameters of some drugs in birds after extrapolation from mammals (e.g. clearance of enrofloxacin, salicylic acid, meloxicam and flunixin), show that pharmacokinetic data on mammals can hardly be extrapolated to birds as such. Furthermore, differences in pharmacokinetic behavior between bird species exist as well. Therefore, the selection of an appropriate posology for birds has to be based on pharmacokinetic data of that specific bird species. In absence of these data, dose selection might be done using allometric scaling. The pharmacokinetic data are scaled in correlation to the body weight of a different bird species. In case these data are also not available, dose selection using allometric scaling with pharmacokinetic data from mammals should preferably only be done for drugs with a low toxicity.},
  author       = {Houben, Ren{\'e}e and Antonissen, Gunther and Croubels, Siska and De Backer, Patrick and Devreese, Mathias},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {PREDICTION,CLEARANCE,CONJUGATION,BENZOIC-ACID,SCAVENGING BIRDS,ALLOMETRIC ANALYSIS,FLUNIXIN MEGLUMINE,SINGLE,KIDNEY,PHARMACODYNAMICS},
  language     = {dut},
  number       = {3},
  pages        = {124--132},
  title        = {Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie},
  url          = {http://vdt.ugent.be/sites/default/files/art2inDutch.pdf},
  volume       = {85},
  year         = {2016},
}

Chicago
Houben, Renée, Gunther Antonissen, Siska Croubels, Patrick De Backer, and Mathias Devreese. 2016. “Farmacokinetiek Van Geneesmiddelen Bij Vogels En De Toepassingen En Beperkingen Van Dosisextrapolatie.” Vlaams Diergeneeskundig Tijdschrift 85 (3): 124–132.
APA
Houben, R., Antonissen, G., Croubels, S., De Backer, P., & Devreese, M. (2016). Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 85(3), 124–132.
Vancouver
1.
Houben R, Antonissen G, Croubels S, De Backer P, Devreese M. Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2016;85(3):124–32.
MLA
Houben, Renée, Gunther Antonissen, Siska Croubels, et al. “Farmacokinetiek Van Geneesmiddelen Bij Vogels En De Toepassingen En Beperkingen Van Dosisextrapolatie.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 85.3 (2016): 124–132. Print.