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Assessment of ovarian cancer tumors treated with intraperitoneal cisplatin therapy by nanoscopic X-ray fluorescence imaging

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Abstract
Ovarian cancer is amongst the most common types of cancer in women, with a relatively low overall cure rate of approximately 30%. This is therefore an important incentive to urge for further research in order to maximize the chances of survival for these patients. Intraperitoneal chemotherapy with Cisplatin is an effective treatement for ovarian cancer; however, many questions still remain concerning the ideal treatment protocol and tumor resistance towards the drug, which should be resolved for optimal application of this therapy. For the first time in-vivo grown tumors treated with both hyper- and normothermic intraperitoneal chemotherapy have been studied using nano-XRF spectroscopy to examine the platinum (Pt) distribution within the analyzed tissues. These measurements prove Pt resides predominantly outsides the cancer cells in the stroma of the tissue. These findings indicate the resistance mechanism of the cancer cells prevents Cisplatin from diffusing through their cell membranes. This is an important addition to the existing knowledge on the resistance mechanism providing insights which might help to overcome this effect. In our aim to find the optimal treatment protocol, no significant differences were found between the two examined procedures. A more extensive data set will be needed to draw definite conclusions.
Keywords
MONTE-CARLO-SIMULATION, ADENOCARCINOMA CELLS, RESISTANCE, PLATINUM, CHEMOTHERAPY, PENETRATION, MICROENVIRONMENT, SPECTROMETERS, SPECTRA

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Citation

Please use this url to cite or link to this publication:

MLA
Laforce, Brecht et al. “Assessment of Ovarian Cancer Tumors Treated with Intraperitoneal Cisplatin Therapy by Nanoscopic X-ray Fluorescence Imaging.” SCIENTIFIC REPORTS 6 (2016): n. pag. Print.
APA
Laforce, B., Carlier, C., Vekemans, B., Villanova, J., Tucoulou, R., Ceelen, W., & Vincze, L. (2016). Assessment of ovarian cancer tumors treated with intraperitoneal cisplatin therapy by nanoscopic X-ray fluorescence imaging. SCIENTIFIC REPORTS, 6.
Chicago author-date
Laforce, Brecht, Charlotte Carlier, Bart Vekemans, Julie Villanova, Rémi Tucoulou, Wim Ceelen, and Laszlo Vincze. 2016. “Assessment of Ovarian Cancer Tumors Treated with Intraperitoneal Cisplatin Therapy by Nanoscopic X-ray Fluorescence Imaging.” Scientific Reports 6.
Chicago author-date (all authors)
Laforce, Brecht, Charlotte Carlier, Bart Vekemans, Julie Villanova, Rémi Tucoulou, Wim Ceelen, and Laszlo Vincze. 2016. “Assessment of Ovarian Cancer Tumors Treated with Intraperitoneal Cisplatin Therapy by Nanoscopic X-ray Fluorescence Imaging.” Scientific Reports 6.
Vancouver
1.
Laforce B, Carlier C, Vekemans B, Villanova J, Tucoulou R, Ceelen W, et al. Assessment of ovarian cancer tumors treated with intraperitoneal cisplatin therapy by nanoscopic X-ray fluorescence imaging. SCIENTIFIC REPORTS. 2016;6.
IEEE
[1]
B. Laforce et al., “Assessment of ovarian cancer tumors treated with intraperitoneal cisplatin therapy by nanoscopic X-ray fluorescence imaging,” SCIENTIFIC REPORTS, vol. 6, 2016.
@article{8044984,
  abstract     = {Ovarian cancer is amongst the most common types of cancer in women, with a relatively low overall cure rate of approximately 30%. This is therefore an important incentive to urge for further research in order to maximize the chances of survival for these patients. Intraperitoneal chemotherapy with Cisplatin is an effective treatement for ovarian cancer; however, many questions still remain concerning the ideal treatment protocol and tumor resistance towards the drug, which should be resolved for optimal application of this therapy. For the first time in-vivo grown tumors treated with both hyper- and normothermic intraperitoneal chemotherapy have been studied using nano-XRF spectroscopy to examine the platinum (Pt) distribution within the analyzed tissues. These measurements prove Pt resides predominantly outsides the cancer cells in the stroma of the tissue. These findings indicate the resistance mechanism of the cancer cells prevents Cisplatin from diffusing through their cell membranes. This is an important addition to the existing knowledge on the resistance mechanism providing insights which might help to overcome this effect. In our aim to find the optimal treatment protocol, no significant differences were found between the two examined procedures. A more extensive data set will be needed to draw definite conclusions.},
  articleno    = {29999},
  author       = {Laforce, Brecht and Carlier, Charlotte and Vekemans, Bart and Villanova, Julie and Tucoulou, Rémi and Ceelen, Wim and Vincze, Laszlo},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {MONTE-CARLO-SIMULATION,ADENOCARCINOMA CELLS,RESISTANCE,PLATINUM,CHEMOTHERAPY,PENETRATION,MICROENVIRONMENT,SPECTROMETERS,SPECTRA},
  language     = {eng},
  pages        = {8},
  title        = {Assessment of ovarian cancer tumors treated with intraperitoneal cisplatin therapy by nanoscopic X-ray fluorescence imaging},
  url          = {http://dx.doi.org/10.1038/srep29999},
  volume       = {6},
  year         = {2016},
}

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