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Caloric restriction: beneficial effects on brain aging and Alzheimer's disease

(2016) MAMMALIAN GENOME. 27(7-8). p.300-319
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Abstract
Dietary interventions such as caloric restriction (CR) extend lifespan and health span. Recent data from animal and human studies indicate that CR slows down the aging process, benefits general health, and improves memory performance. Caloric restriction also retards and slows down the progression of different age-related diseases, such as Alzheimer's disease. However, the specific molecular basis of these effects remains unclear. A better understanding of the pathways underlying these effects could pave the way to novel preventive or therapeutic strategies. In this review, we will discuss the mechanisms and effects of CR on aging and Alzheimer's disease. A potential alternative to CR as a lifestyle modification is the use of CR mimetics. These compounds mimic the biochemical and functional effects of CR without the need to reduce energy intake. We discuss the effect of two of the most investigated mimetics, resveratrol and rapamycin, on aging and their potential as Alzheimer's disease therapeutics. However, additional research will be needed to determine the safety, efficacy, and usability of CR and its mimetics before a general recommendation can be proposed to implement them.
Keywords
EXTENDS LIFE-SPAN, AMYOTROPHIC-LATERAL-SCLEROSIS, GENETICALLY HETEROGENEOUS MICE, RANDOMIZED CONTROLLED-TRIAL, HYDROGEN-SULFIDE PRODUCTION, ONSET DIETARY RESTRICTION, MOUSE MODEL, METHIONINE RESTRICTION, CAENORHABDITIS-ELEGANS, OXIDATIVE STRESS

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Citation

Please use this url to cite or link to this publication:

MLA
Van Cauwenberghe, Caroline et al. “Caloric Restriction: Beneficial Effects on Brain Aging and Alzheimer’s Disease.” MAMMALIAN GENOME 27.7-8 (2016): 300–319. Print.
APA
Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. (2016). Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease. MAMMALIAN GENOME, 27(7-8), 300–319.
Chicago author-date
Van Cauwenberghe, Caroline, Charysse Vandendriessche, Claude Libert, and Roosmarijn Vandenbroucke. 2016. “Caloric Restriction: Beneficial Effects on Brain Aging and Alzheimer’s Disease.” Mammalian Genome 27 (7-8): 300–319.
Chicago author-date (all authors)
Van Cauwenberghe, Caroline, Charysse Vandendriessche, Claude Libert, and Roosmarijn Vandenbroucke. 2016. “Caloric Restriction: Beneficial Effects on Brain Aging and Alzheimer’s Disease.” Mammalian Genome 27 (7-8): 300–319.
Vancouver
1.
Van Cauwenberghe C, Vandendriessche C, Libert C, Vandenbroucke R. Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease. MAMMALIAN GENOME. 2016;27(7-8):300–19.
IEEE
[1]
C. Van Cauwenberghe, C. Vandendriessche, C. Libert, and R. Vandenbroucke, “Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease,” MAMMALIAN GENOME, vol. 27, no. 7–8, pp. 300–319, 2016.
@article{8044965,
  abstract     = {Dietary interventions such as caloric restriction (CR) extend lifespan and health span. Recent data from animal and human studies indicate that CR slows down the aging process, benefits general health, and improves memory performance. Caloric restriction also retards and slows down the progression of different age-related diseases, such as Alzheimer's disease. However, the specific molecular basis of these effects remains unclear. A better understanding of the pathways underlying these effects could pave the way to novel preventive or therapeutic strategies. In this review, we will discuss the mechanisms and effects of CR on aging and Alzheimer's disease. A potential alternative to CR as a lifestyle modification is the use of CR mimetics. These compounds mimic the biochemical and functional effects of CR without the need to reduce energy intake. We discuss the effect of two of the most investigated mimetics, resveratrol and rapamycin, on aging and their potential as Alzheimer's disease therapeutics. However, additional research will be needed to determine the safety, efficacy, and usability of CR and its mimetics before a general recommendation can be proposed to implement them.},
  author       = {Van Cauwenberghe, Caroline and Vandendriessche, Charysse and Libert, Claude and Vandenbroucke, Roosmarijn},
  issn         = {0938-8990},
  journal      = {MAMMALIAN GENOME},
  keywords     = {EXTENDS LIFE-SPAN,AMYOTROPHIC-LATERAL-SCLEROSIS,GENETICALLY HETEROGENEOUS MICE,RANDOMIZED CONTROLLED-TRIAL,HYDROGEN-SULFIDE PRODUCTION,ONSET DIETARY RESTRICTION,MOUSE MODEL,METHIONINE RESTRICTION,CAENORHABDITIS-ELEGANS,OXIDATIVE STRESS},
  language     = {eng},
  number       = {7-8},
  pages        = {300--319},
  title        = {Caloric restriction: beneficial effects on brain aging and Alzheimer's disease},
  url          = {http://dx.doi.org/10.1007/s00335-016-9647-6},
  volume       = {27},
  year         = {2016},
}

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