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The effect of aging on brain barriers and the consequences for Alzheimer's disease development

(2016) MAMMALIAN GENOME. 27(7-8). p.407-420
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Abstract
Life expectancy has increased in most developed countries, which has led to an increase in the proportion of elderly people in the world's population. However, this increase in life expectancy is not accompanied by a lengthening of the health span since aging is characterized with progressive deterioration in cellular and organ functions. The brain is particularly vulnerable to disease, and this is reflected in the onset of age-related neurodegenerative diseases such as Alzheimer's disease. Research shows that dysfunction of two barriers in the central nervous system (CNS), the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB), plays an important role in the progression of these neurodegenerative diseases. The BBB is formed by the endothelial cells of the blood capillaries, whereas the BCSFB is formed by the epithelial cells of the choroid plexus (CP), both of which are affected during aging. Here, we give an overview of how these barriers undergo changes during aging and in Alzheimer's disease, thereby disturbing brain homeostasis. Studying these changes is needed in order to gain a better understanding of the mechanisms of aging at the brain barriers, which might lead to the development of new therapies to lengthen the health span (including mental health) and reduce the chances of developing Alzheimer's disease.
Keywords
CENTRAL-NERVOUS-SYSTEM, PERIPHERAL INFLAMMATORY STIMULUS, CEREBRAL MICROVASCULAR PATHOLOGY, CEREBROSPINAL FLUID SYSTEM, CHOROID-PLEXUS EPITHELIUM, AGE-RELATED-CHANGES, BLOOD-CSF BARRIER, AMYLOID-BETA, GROWTH-FACTOR, T-CELLS

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Chicago
Gorlé, Nina, Caroline Van Cauwenberghe, Claude Libert, and Roosmarijn Vandenbroucke. 2016. “The Effect of Aging on Brain Barriers and the Consequences for Alzheimer’s Disease Development.” Mammalian Genome 27 (7-8): 407–420.
APA
Gorlé, N., Van Cauwenberghe, C., Libert, C., & Vandenbroucke, R. (2016). The effect of aging on brain barriers and the consequences for Alzheimer’s disease development. MAMMALIAN GENOME, 27(7-8), 407–420.
Vancouver
1.
Gorlé N, Van Cauwenberghe C, Libert C, Vandenbroucke R. The effect of aging on brain barriers and the consequences for Alzheimer’s disease development. MAMMALIAN GENOME. 2016;27(7-8):407–20.
MLA
Gorlé, Nina, Caroline Van Cauwenberghe, Claude Libert, et al. “The Effect of Aging on Brain Barriers and the Consequences for Alzheimer’s Disease Development.” MAMMALIAN GENOME 27.7-8 (2016): 407–420. Print.
@article{8044959,
  abstract     = {Life expectancy has increased in most developed countries, which has led to an increase in the proportion of elderly people in the world's population. However, this increase in life expectancy is not accompanied by a lengthening of the health span since aging is characterized with progressive deterioration in cellular and organ functions. The brain is particularly vulnerable to disease, and this is reflected in the onset of age-related neurodegenerative diseases such as Alzheimer's disease. Research shows that dysfunction of two barriers in the central nervous system (CNS), the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB), plays an important role in the progression of these neurodegenerative diseases. The BBB is formed by the endothelial cells of the blood capillaries, whereas the BCSFB is formed by the epithelial cells of the choroid plexus (CP), both of which are affected during aging. Here, we give an overview of how these barriers undergo changes during aging and in Alzheimer's disease, thereby disturbing brain homeostasis. Studying these changes is needed in order to gain a better understanding of the mechanisms of aging at the brain barriers, which might lead to the development of new therapies to lengthen the health span (including mental health) and reduce the chances of developing Alzheimer's disease.},
  author       = {Gorl{\'e}, Nina and Van Cauwenberghe, Caroline and Libert, Claude and Vandenbroucke, Roosmarijn},
  issn         = {0938-8990},
  journal      = {MAMMALIAN GENOME},
  keyword      = {CENTRAL-NERVOUS-SYSTEM,PERIPHERAL INFLAMMATORY STIMULUS,CEREBRAL MICROVASCULAR PATHOLOGY,CEREBROSPINAL FLUID SYSTEM,CHOROID-PLEXUS EPITHELIUM,AGE-RELATED-CHANGES,BLOOD-CSF BARRIER,AMYLOID-BETA,GROWTH-FACTOR,T-CELLS},
  language     = {eng},
  number       = {7-8},
  pages        = {407--420},
  title        = {The effect of aging on brain barriers and the consequences for Alzheimer's disease development},
  url          = {http://dx.doi.org/10.1007/s00335-016-9637-8},
  volume       = {27},
  year         = {2016},
}

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