Advanced search
1 file | 155.01 KB

Treatment of sarcoids in equids : 230 cases (2008–2013)

Maarten Haspeslagh (UGent) , Lieven Vlaminck (UGent) and Ann Martens (UGent)
Author
Organization
Abstract
OBJECTIVE : To evaluate outcomes following treatment of sarcoids in equids and to identify risk factors for treatment failure in these patients. DESIGN : Retrospective case series. ANIMALS : 230 equids with 614 sarcoids. PROCEDURES : Records were searched to identify equids treated for >= 1 sarcoid between 2008 and 2013. A standardized protocol was used to determine treatment choice (electrosurgery, electrosurgery with intralesional placement of cisplatin-containing beads, topical administration of imiquimod or acyclovir, cryosurgery, bacillus Calmette-Guerin vaccine injection, or intralesional injection of platinum-containing drugs). Data regarding animal, tumor, treatment, and outcome variables were collected. Complete tumor regression without recurrence for >= 6 months was considered a successful outcome. Success rates were calculated; binary logistic regression analysis was used to identify risk factors for treatment failure and to compare effects of the 2 topical treatments. A.2 test was used to compare effects of the number of Bacillus Calmette-Guerin vaccine or cisplatin-containing drug injections on outcome. RESULTS : The overall success rate was 460 of 614 (74.9%). Electrosurgical excision resulted in the highest treatment success rate (277/319 [86.8%]); odds of treatment failure were significantly greater for intralesional injection of platinum-containing drugs, cryosurgery, and topical acyclovir treatment. Odds of treatment failure were also significantly greater for sarcoids on equids with multiple tumors than for solitary lesions, and significantly lower for sarcoids on equids that received concurrent immunostimulating treatment for another sarcoid than for those on patients that did not receive such treatment. CONCLUSIONS AND CLINICAL RELEVANCE : Selection bias for treatments was inherent to the study design; however, results may assist clinicians in selecting treatments and in determining prognosis for equids with sarcoids treated according to the described methods.
Keywords
CARBON-DIOXIDE LASER, INTERSTITIAL BRACHYTHERAPY, CRYOSURGERY, HORSES, IMMUNOTHERAPY, MANAGEMENT, CISPLATIN, EMULSION, THERAPY, IR-192

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 155.01 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Haspeslagh, Maarten, Lieven Vlaminck, and Ann Martens. 2016. “Treatment of Sarcoids in Equids : 230 Cases (2008–2013).” Javma-journal of the American Veterinary Medical Association 249 (3): 311–318.
APA
Haspeslagh, Maarten, Vlaminck, L., & Martens, A. (2016). Treatment of sarcoids in equids : 230 cases (2008–2013). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 249(3), 311–318.
Vancouver
1.
Haspeslagh M, Vlaminck L, Martens A. Treatment of sarcoids in equids : 230 cases (2008–2013). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION. 2016;249(3):311–8.
MLA
Haspeslagh, Maarten, Lieven Vlaminck, and Ann Martens. “Treatment of Sarcoids in Equids : 230 Cases (2008–2013).” JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION 249.3 (2016): 311–318. Print.
@article{8043714,
  abstract     = {OBJECTIVE : To evaluate outcomes following treatment of sarcoids in equids and to identify risk factors for treatment failure in these patients. 
DESIGN : Retrospective case series. 
ANIMALS : 230 equids with 614 sarcoids. 
PROCEDURES : Records were searched to identify equids treated for >= 1 sarcoid between 2008 and 2013. A standardized protocol was used to determine treatment choice (electrosurgery, electrosurgery with intralesional placement of cisplatin-containing beads, topical administration of imiquimod or acyclovir, cryosurgery, bacillus Calmette-Guerin vaccine injection, or intralesional injection of platinum-containing drugs). Data regarding animal, tumor, treatment, and outcome variables were collected. Complete tumor regression without recurrence for >= 6 months was considered a successful outcome. Success rates were calculated; binary logistic regression analysis was used to identify risk factors for treatment failure and to compare effects of the 2 topical treatments. A.2 test was used to compare effects of the number of Bacillus Calmette-Guerin vaccine or cisplatin-containing drug injections on outcome. 
RESULTS : The overall success rate was 460 of 614 (74.9%). Electrosurgical excision resulted in the highest treatment success rate (277/319 [86.8%]); odds of treatment failure were significantly greater for intralesional injection of platinum-containing drugs, cryosurgery, and topical acyclovir treatment. Odds of treatment failure were also significantly greater for sarcoids on equids with multiple tumors than for solitary lesions, and significantly lower for sarcoids on equids that received concurrent immunostimulating treatment for another sarcoid than for those on patients that did not receive such treatment. 
CONCLUSIONS AND CLINICAL RELEVANCE : Selection bias for treatments was inherent to the study design; however, results may assist clinicians in selecting treatments and in determining prognosis for equids with sarcoids treated according to the described methods.},
  author       = {Haspeslagh, Maarten and Vlaminck, Lieven and Martens, Ann},
  issn         = {0003-1488},
  journal      = {JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION},
  keywords     = {CARBON-DIOXIDE LASER,INTERSTITIAL BRACHYTHERAPY,CRYOSURGERY,HORSES,IMMUNOTHERAPY,MANAGEMENT,CISPLATIN,EMULSION,THERAPY,IR-192},
  language     = {eng},
  number       = {3},
  pages        = {311--318},
  title        = {Treatment of sarcoids in equids : 230 cases (2008–2013)},
  url          = {http://dx.doi.org/10.2460/javma.249.3.311},
  volume       = {249},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: