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Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses

Sharen Provoost (UGent) , Katrien De Grove (UGent) , Graeme L Fraser, Vincent J Lannoy, Kurt Tournoy (UGent) , Guy Brusselle (UGent) , Tania Maes (UGent) and Guy Joos (UGent)
(2016) JOURNAL OF IMMUNOLOGY. 196(4). p.1882-1890
Author
Organization
Abstract
Inhalation of traffic-related particulate matter (e.g., diesel exhaust particles [DEPs]) is associated with acute inflammatory responses in the lung, and it promotes the development and aggravation of allergic airway diseases. We previously demonstrated that exposure to DEP was associated with increased recruitment and maturation of monocytes and conventional dendritic cells (DCs), resulting in T(H)2 polarization. Monocytes and immature DCs express the G-protein coupled receptor chemR23, which binds the chemoattractant chemerin. Using chemR23 knockout (KO) and corresponding wild-type (WT) mice, we determined the role of chemR23 signaling in response to acute exposure to DEPs and in response to DEP-enhanced house dust mite (HDM)-induced allergic airway inflammation. Exposure to DEP alone, as well as combined exposure to DEP plus HDM, elevated the levels of chemerin in the bronchoalveolar lavage fluid of WT mice. In response to acute exposure to DEPs, monocytes and monocyte-derived DCs accumulated in the lungs of WT mice, but this response was significantly attenuated in chemR23 KO mice. Concomitant exposure to DEP plus HDM resulted in allergic airway inflammation with increased eosinophilia, goblet cell metaplasia, and TH2 cytokine production in WT mice, which was further enhanced in chemR23 KO mice. In conclusion, we demonstrated an opposing role for chemR23 signaling depending on the context of DEP-induced inflammation. The chemR23 axis showed proinflammatory properties in a model of DEP-induced acute lung inflammation, in contrast to anti-inflammatory effects in a model of DEP-enhanced allergic airway inflammation.
Keywords
RESOLVIN E1, ASTHMA, DENDRITIC CELLS, ALLERGIC AIRWAY INFLAMMATION, CHEMERIN, RECRUITMENT, RESOLUTION, IMMUNITY, RECEPTOR, SENSITIZATION

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MLA
Provoost, Sharen et al. “Pro- and Anti-inflammatory Role of ChemR23 Signaling in Pollutant-induced Inflammatory Lung Responses.” JOURNAL OF IMMUNOLOGY 196.4 (2016): 1882–1890. Print.
APA
Provoost, Sharen, De Grove, K., Fraser, G. L., Lannoy, V. J., Tournoy, K., Brusselle, G., Maes, T., et al. (2016). Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses. JOURNAL OF IMMUNOLOGY, 196(4), 1882–1890.
Chicago author-date
Provoost, Sharen, Katrien De Grove, Graeme L Fraser, Vincent J Lannoy, Kurt Tournoy, Guy Brusselle, Tania Maes, and Guy Joos. 2016. “Pro- and Anti-inflammatory Role of ChemR23 Signaling in Pollutant-induced Inflammatory Lung Responses.” Journal of Immunology 196 (4): 1882–1890.
Chicago author-date (all authors)
Provoost, Sharen, Katrien De Grove, Graeme L Fraser, Vincent J Lannoy, Kurt Tournoy, Guy Brusselle, Tania Maes, and Guy Joos. 2016. “Pro- and Anti-inflammatory Role of ChemR23 Signaling in Pollutant-induced Inflammatory Lung Responses.” Journal of Immunology 196 (4): 1882–1890.
Vancouver
1.
Provoost S, De Grove K, Fraser GL, Lannoy VJ, Tournoy K, Brusselle G, et al. Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses. JOURNAL OF IMMUNOLOGY. 2016;196(4):1882–90.
IEEE
[1]
S. Provoost et al., “Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses,” JOURNAL OF IMMUNOLOGY, vol. 196, no. 4, pp. 1882–1890, 2016.
@article{8037263,
  abstract     = {Inhalation of traffic-related particulate matter (e.g., diesel exhaust particles [DEPs]) is associated with acute inflammatory responses in the lung, and it promotes the development and aggravation of allergic airway diseases. We previously demonstrated that exposure to DEP was associated with increased recruitment and maturation of monocytes and conventional dendritic cells (DCs), resulting in T(H)2 polarization. Monocytes and immature DCs express the G-protein coupled receptor chemR23, which binds the chemoattractant chemerin. Using chemR23 knockout (KO) and corresponding wild-type (WT) mice, we determined the role of chemR23 signaling in response to acute exposure to DEPs and in response to DEP-enhanced house dust mite (HDM)-induced allergic airway inflammation. Exposure to DEP alone, as well as combined exposure to DEP plus HDM, elevated the levels of chemerin in the bronchoalveolar lavage fluid of WT mice. In response to acute exposure to DEPs, monocytes and monocyte-derived DCs accumulated in the lungs of WT mice, but this response was significantly attenuated in chemR23 KO mice. Concomitant exposure to DEP plus HDM resulted in allergic airway inflammation with increased eosinophilia, goblet cell metaplasia, and TH2 cytokine production in WT mice, which was further enhanced in chemR23 KO mice. In conclusion, we demonstrated an opposing role for chemR23 signaling depending on the context of DEP-induced inflammation. The chemR23 axis showed proinflammatory properties in a model of DEP-induced acute lung inflammation, in contrast to anti-inflammatory effects in a model of DEP-enhanced allergic airway inflammation.},
  author       = {Provoost, Sharen and De Grove, Katrien and Fraser, Graeme L and Lannoy, Vincent J and Tournoy, Kurt and Brusselle, Guy and Maes, Tania and Joos, Guy},
  issn         = {0022-1767},
  journal      = {JOURNAL OF IMMUNOLOGY},
  keywords     = {RESOLVIN E1,ASTHMA,DENDRITIC CELLS,ALLERGIC AIRWAY INFLAMMATION,CHEMERIN,RECRUITMENT,RESOLUTION,IMMUNITY,RECEPTOR,SENSITIZATION},
  language     = {eng},
  number       = {4},
  pages        = {1882--1890},
  title        = {Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses},
  url          = {http://dx.doi.org/10.4049/jimmunol.1501113},
  volume       = {196},
  year         = {2016},
}

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