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Lessons from domestication: targeting cis-regulatory elements for crop improvement

Gwen Swinnen (UGent) , Alain Goossens (UGent) and Laurens Pauwels (UGent)
(2016) TRENDS IN PLANT SCIENCE. 21(6). p.506-515
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Abstract
Domestication of wild plant species has provided us with crops that serve our human nutritional needs. Advanced DNA sequencing has propelled the unveiling of underlying genetic changes associated with domestication. Interestingly, many changes reside in cis-regulatory elements (CREs) that control the expression of an unmodified coding sequence. Sequence variation in CREs can impact gene expression levels, but also developmental timing and tissue specificity of expression. When genes are involved in multiple pathways or active in several organs and developmental stages CRE modifications are favored in contrast to mutations in coding regions, due to the lack of detrimental pleiotropic effects. Therefore, learning from domestication, we propose that CREs are interesting targets for genome editing to create new alleles for plant breeding.
Keywords
NATURAL VARIATION, MERISTEM SIZE, RICE DOMESTICATION, MAIZE DOMESTICATION, ARABIDOPSIS-THALIANA, GRAIN-SIZE, DNA-BINDING-SITE, TOMATO FRUIT SIZE, STEM-CELL MAINTENANCE, PLANT TRANSCRIPTION FACTORS

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Chicago
Swinnen, Gwen, Alain Goossens, and Laurens Pauwels. 2016. “Lessons from Domestication: Targeting Cis-regulatory Elements for Crop Improvement.” Trends in Plant Science 21 (6): 506–515.
APA
Swinnen, G., Goossens, A., & Pauwels, L. (2016). Lessons from domestication: targeting cis-regulatory elements for crop improvement. TRENDS IN PLANT SCIENCE, 21(6), 506–515.
Vancouver
1.
Swinnen G, Goossens A, Pauwels L. Lessons from domestication: targeting cis-regulatory elements for crop improvement. TRENDS IN PLANT SCIENCE. 2016;21(6):506–15.
MLA
Swinnen, Gwen, Alain Goossens, and Laurens Pauwels. “Lessons from Domestication: Targeting Cis-regulatory Elements for Crop Improvement.” TRENDS IN PLANT SCIENCE 21.6 (2016): 506–515. Print.
@article{8036599,
  abstract     = {Domestication of wild plant species has provided us with crops that serve our human nutritional needs. Advanced DNA sequencing has propelled the unveiling of underlying genetic changes associated with domestication. Interestingly, many changes reside in cis-regulatory elements (CREs) that control the expression of an unmodified coding sequence. Sequence variation in CREs can impact gene expression levels, but also developmental timing and tissue specificity of expression. When genes are involved in multiple pathways or active in several organs and developmental stages CRE modifications are favored in contrast to mutations in coding regions, due to the lack of detrimental pleiotropic effects. Therefore, learning from domestication, we propose that CREs are interesting targets for genome editing to create new alleles for plant breeding.},
  author       = {Swinnen, Gwen and Goossens, Alain and Pauwels, Laurens},
  issn         = {1360-1385},
  journal      = {TRENDS IN PLANT SCIENCE},
  keywords     = {NATURAL VARIATION,MERISTEM SIZE,RICE DOMESTICATION,MAIZE DOMESTICATION,ARABIDOPSIS-THALIANA,GRAIN-SIZE,DNA-BINDING-SITE,TOMATO FRUIT SIZE,STEM-CELL MAINTENANCE,PLANT TRANSCRIPTION FACTORS},
  language     = {eng},
  number       = {6},
  pages        = {506--515},
  title        = {Lessons from domestication: targeting cis-regulatory elements for crop improvement},
  url          = {http://dx.doi.org/10.1016/j.tplants.2016.01.014},
  volume       = {21},
  year         = {2016},
}

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