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Susceptibility assay of Haemonchus contortus to commonly used anthelmintics in Jimma, southwest Ethiopia

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Abstract
An experimental study to investigate the susceptibility pattern of Haemonchus contortus to commonly used anthelmintics (albendazole, tetramisole, ivermectin, and triclobendazole) was conducted between June and September 2009. Adult H. contortus parasites were collected from a total of 30 sheep slaughtered at Jimma municipal abattoir. The anthelmintics were assessed for egg hatch inhibition ability against H. contortus eggs. The eggs (500 eggs/ml) were incubated with different concentrations (0.25, 0.125, 0.0625, 0.03125, and 0.015625 mu g/ml) at 26A degrees C for 48 h. Egg hatching inhibition of different anthelmintics at different concentrations was recorded. The overall mean percent inhibition showed that there was a significant difference (p < 0.05) among the different concentrations. Mean egg hatch inhibition of ivermectin showed the highest result (84.90 %) at 0.25 mu g/ml, followed by albendazole (78.77 %), triclobendazole (76.66 %), and tetramisole (78.98 %), respectively. The overall mean percent inhibition showed a significant difference (p < 0.05) among the different anthelmintics. Further evaluation of these anthelmintics was recommended.
Keywords
Haemonchus contortus, In vitro, Resistance, GASTROINTESTINAL NEMATODES, VETERINARY IMPORTANCE, RESISTANCE, SHEEP, EPIDEMIOLOGY, ALBENDAZOLE, Egg hatch assay, Anthelmintics

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MLA
Belew, Sileshi et al. “Susceptibility Assay of Haemonchus Contortus to Commonly Used Anthelmintics in Jimma, Southwest Ethiopia.” TROPICAL ANIMAL HEALTH AND PRODUCTION 44.7 (2012): 1599–1603. Print.
APA
Belew, S., Hussien, J., Regassa, F., Belay, K., & Fulasa, T. T. (2012). Susceptibility assay of Haemonchus contortus to commonly used anthelmintics in Jimma, southwest Ethiopia. TROPICAL ANIMAL HEALTH AND PRODUCTION, 44(7), 1599–1603.
Chicago author-date
Belew, Sileshi, Jemal Hussien, Feyesa Regassa, Kumilachew Belay, and Tadele Tolosa Fulasa. 2012. “Susceptibility Assay of Haemonchus Contortus to Commonly Used Anthelmintics in Jimma, Southwest Ethiopia.” Tropical Animal Health and Production 44 (7): 1599–1603.
Chicago author-date (all authors)
Belew, Sileshi, Jemal Hussien, Feyesa Regassa, Kumilachew Belay, and Tadele Tolosa Fulasa. 2012. “Susceptibility Assay of Haemonchus Contortus to Commonly Used Anthelmintics in Jimma, Southwest Ethiopia.” Tropical Animal Health and Production 44 (7): 1599–1603.
Vancouver
1.
Belew S, Hussien J, Regassa F, Belay K, Fulasa TT. Susceptibility assay of Haemonchus contortus to commonly used anthelmintics in Jimma, southwest Ethiopia. TROPICAL ANIMAL HEALTH AND PRODUCTION. 2012;44(7):1599–603.
IEEE
[1]
S. Belew, J. Hussien, F. Regassa, K. Belay, and T. T. Fulasa, “Susceptibility assay of Haemonchus contortus to commonly used anthelmintics in Jimma, southwest Ethiopia,” TROPICAL ANIMAL HEALTH AND PRODUCTION, vol. 44, no. 7, pp. 1599–1603, 2012.
@article{8035465,
  abstract     = {{An experimental study to investigate the susceptibility pattern of Haemonchus contortus to commonly used anthelmintics (albendazole, tetramisole, ivermectin, and triclobendazole) was conducted between June and September 2009. Adult H. contortus parasites were collected from a total of 30 sheep slaughtered at Jimma municipal abattoir. The anthelmintics were assessed for egg hatch inhibition ability against H. contortus eggs. The eggs (500 eggs/ml) were incubated with different concentrations (0.25, 0.125, 0.0625, 0.03125, and 0.015625 mu g/ml) at 26A degrees C for 48 h. Egg hatching inhibition of different anthelmintics at different concentrations was recorded. The overall mean percent inhibition showed that there was a significant difference (p < 0.05) among the different concentrations. Mean egg hatch inhibition of ivermectin showed the highest result (84.90 %) at 0.25 mu g/ml, followed by albendazole (78.77 %), triclobendazole (76.66 %), and tetramisole (78.98 %), respectively. The overall mean percent inhibition showed a significant difference (p < 0.05) among the different anthelmintics. Further evaluation of these anthelmintics was recommended.}},
  author       = {{Belew, Sileshi and Hussien, Jemal and Regassa, Feyesa and Belay, Kumilachew and Fulasa, Tadele Tolosa}},
  issn         = {{0049-4747}},
  journal      = {{TROPICAL ANIMAL HEALTH AND PRODUCTION}},
  keywords     = {{Haemonchus contortus,In vitro,Resistance,GASTROINTESTINAL NEMATODES,VETERINARY IMPORTANCE,RESISTANCE,SHEEP,EPIDEMIOLOGY,ALBENDAZOLE,Egg hatch assay,Anthelmintics}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1599--1603}},
  title        = {{Susceptibility assay of Haemonchus contortus to commonly used anthelmintics in Jimma, southwest Ethiopia}},
  url          = {{http://dx.doi.org/10.1007/s11250-012-0113-5}},
  volume       = {{44}},
  year         = {{2012}},
}

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